Oxadiazolone bioisosteres of pregabalin and gabapentin

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 247-250

  Wustrow, David J ^a   Belliotti, Thomas R ^a   Capiris, Thomas ^a   Kneen, Clare O ^b   Bryans, Justin S ^b   Field, Mark J ^b   Williams, Dic ^b   El Kattan, Ayman ^a   Buchholz, Lisa ^a   Kinsora, Jack J ^a   Lotarski, Susan M ^a   Vartanian, Mark G ^a   Taylor, Charles P ^a   Donevan, Sean D ^a   Thorpe, Andrew J ^c   Schwarz, Jacob B ^a  

^a PFIZER INC   (United States)

^b Sandwich Laboratories   (United Kingdom)

^c Missouri Department of Transportation   (United States)

Author keywords

2 ; Acid bioisostere; Gabapentin; Oxadiazolone; Pregabalin

Indexed keywords

CIMETIDINE; GABAPENTIN; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; OXADIAZOLE DERIVATIVE; PD 200347; PREGABALIN; PROBENECID; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG UPTAKE; NONHUMAN; OSTEOARTHRITIS; RAT; SEIZURE;

AMINES; ANIMALS; BRAIN; CYCLOHEXANECARBOXYLIC ACIDS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; GAMMA-AMINOBUTYRIC ACID; OCTAMER TRANSCRIPTION FACTORS; ORGANIC ANION TRANSPORTERS; OSTEOARTHRITIS; OXADIAZOLES; RATS;

EID: 57749085477     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.101     Document Type: Article

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