Carboxylate bioisosteres of pregabalin

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3559-3563

  Schwarz, Jacob B ^a   Colbry, Norman L ^a   Zhu, Zhijian ^a   Nichelson, Brian ^a   Barta, Nancy S ^a   Lin, Kristin ^a   Hudack, Raymond A ^a   Gibbons, Sian E ^a   Galatsis, Paul ^a   DeOrazio, Russell J ^b   Manning, David D ^b   Vartanian, Mark G ^a   Kinsora, Jack J ^a   Lotarski, Susan M ^a   Li, Zheng ^a   Dickerson, Melvin R ^a   El Kattan, Ayman ^a   Thorpe, Andrew J ^a   Donevan, Sean D ^a   Taylor, Charles P ^a   Wustrow, David J ^a   more..

^a PFIZER INC   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

2 Subunit; Gabapentin; Pregabalin; Tetrazole

Indexed keywords

AMINOTETRAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; GABAPENTIN; PREGABALIN; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; IN VIVO STUDY; MOUSE; NONHUMAN;

AMINES; ANIMALS; ANTICONVULSANTS; BINDING SITES; CARBOXYLIC ACIDS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EPILEPSY, REFLEX; GAMMA-AMINOBUTYRIC ACID; MICE; MICE, INBRED DBA; MOLECULAR STRUCTURE; PROTEIN SUBUNITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646854387     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.083     Document Type: Article

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