Investigation into the preferred conformation of Gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 19, 1997, Pages 2481-2484

  Bryans, Justin S ^a   Davies, Natasha ^a   Gee, Nicolas S ^a   Horwell, David C ^a   Kneen, Clare O ^a   Morrell, Andrew I ^a   O'Neill, Jacqueline A ^a   Ratcliffe, Giles S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; GABAPENTIN; GABAPENTIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CIS TRANS ISOMERISM; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0030770209     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10002-6     Document Type: Article

References (8)

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2. Taylor, C. P. Neurology 1994, 44, S10-16.
3. Satzinger, G. Arzneimittelforschung, 1994, 44, 261-6.
4. Gee, N. S.; Brown, J. P.; Dissanayake, V. U. K.; Offord, J.; Thurlow, R.; Woodruff, G. N. J. Biol. Chem. 1996, 271, 5768-76.
5. Griffiths, G.; Mettler, H; Mills, L. S.; Previdoli, F. Helvetica Chimica Acta 1991, 74, 309-14.
6. 1H NMR, infra-red and mass spectra, as well as a satisfactory elemental analysis.
7. Full experimental details will be published elsewhere.
8. Nagata, W.; Yoshioka, M. Organic Reactions 1977, 25, 255-476.