Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 1, 2000, Pages 57-60

  Gargala, Gilles ^a,c   Delaunay, Agnès ^a   Li, Xunde ^b   Brasseur, Philippe ^b   Favennec, Loic ^b   Ballet, Jean Jacques ^a  

^a CAEN UNIVERSITY HOSPITAL   (France)

^b ROUEN UNIVERSITY HOSPITAL   (France)

^c CHU Clemenceau   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBENZOIC ACID; ASCORBIC ACID; GLUCOSE; INSULIN; NITAZOXANIDE; PENICILLIN G; STREPTOMYCIN; TIZOXANIDE; TIZOXANIDE GLUCURONIDE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; GLUCURONIDE; THIAZOLE DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; DRUG EFFECT; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOASSAY; INTESTINE CELL; LIFE CYCLE; NONHUMAN; PARASITE DEVELOPMENT; SPOROZOITE; ANIMAL; CELL LINE; PARASITOLOGY;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; CRYPTOSPORIDIUM PARVUM; ENTEROCYTES; GLUCURONIDES; HUMANS; THIAZOLES;

EID: 0033940907     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.1.57     Document Type: Article

References (15)

1. Griffiths, J. K. (1998). Human cryptosporidiosis: epidemiology, transmission, clinical disease, treatment, and diagnosis. Advances in Parasitology 40, 37-85.
2. Kelly, P., Davies, S. E., Mandanda, B., Veitch, A., McPhail, G., Zulu, I. et al. (1997). Enteropathy in Zambians with HIV related diarrhoea: regression modelling of potential determinants of mucosal damage. Guf 41, 811-6.
3. Blagburn, B. B. L. & Soave, R. (1997). Prophylaxis and chemotherapy: human and animal. In Cryptosporidium and Cryptosporidiosis, (Fayer, R., Ed.), pp. 111-27. CRC Press, Boca Raton, FL.
4. Tzipori, S. (1998). Cryptosporidiosis: laboratory investigations and chemotherapy. Advances in Parasitology 40, 187-221.
5. Bissuel, F., Cotte, L., Rabodonirina, M., Rougier, P., Piens, M. A. & Trepo, C. (1994). Paromomycin: an effective treatment for cryptosporidial diarrhea in patients with AIDS. Clinical Infectious Diseases 18, 447-9.
6. Stockis, A., Lins, R., Deroubaix, X., Jeanbaptiste, B., Calderon, P. & Rossignol, J. F. (1996). Pharmacokinetics of nitazoxanide after single oral dose administration in 6 healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 34, 349-51.
7. Egraz-Bernard, M., Favennec, L., Agnamey, P., Ballet, J. J. & Brasseur, P. (1996). Inhibition of complete development of Cryptosporidium parvum in Caco-2 cells. European Journal of Clinical Microbiology and Infectious Diseases 15, 897-900.
8. Gargala, G., Delaunay, A., Favennec, L., Brasseur, P. & Ballet, J. J. (1999). Enzyme immunoassay detection of Cryptosporidium parvum inhibition by sinefungin in sporozoite infected HCT-8 enterocytic cells. International Journal for Parasitology 29, 703-9.
9. Buraud, M., Forget, E., Favennec, L., Bizet, J., Gobert, J. G. & Deluol, A. M. (1991). Sexual stage development of cryptosporidia in the Caco-2 cell line. Infection and Immunity 59, 4610-3.
10. Maillot, C., Favennec, L., François, A., Ducrotte, P. & Brasseur, P. (1997). Sexual and asexual development of Cryptosporidium parvum in five oocyst- or sporozoite-infected human enterocytic cell lines. Journal of Eukaryotic Microbiology 44, 582-5.
11. Upton, S. J., Tilley, M. & Brillhart, D. B. (1995). Effects of select medium supplements on in vitro development of Cryptosporidium parvum in HCT-8 cells. Journal of Clinical Microbiology 33, 371-5.
12. Theodos, C. M., Griffiths, J. K., D'Onfro, J., Fairfield A. & Tzipori, S. (1998). Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models. Antimicrobial Agents and Chemotherapy 42, 1959-65.
13. Doumbo, O., Rossignol, J. F., Pichard, E., Traore, H. A., Dembele, T. M., Diakite, M. et al. (1997). Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa. American Journal of Tropical Medicine and Hygiene 56, 637-9.
14. Rossignol, J. F., Hidalgo, H., Feregrino, M., Higuera, F., Gomez, W. H., Romero, J. L. et al. (1998). A double-blind placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in AIDS patients in Mexico. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 663-6.
15. Abaza, H., El-Zayadi, A., Kabil, S. M. & Rizk, H. (1998). Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt. Current Therapeutic Research 59, 116-21.