Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip

Genome Biology

Volumn 9, Issue 11, 2008, Pages

  Arora, Shilpi ^a   Wang, Yipeng ^a,b   Jia, Zhenyu ^a   Vardar Sengul, Saynur ^a,c   Munawar, Ayla ^a   Doctor, Kutbuddin S ^d   Birrer, Michael ^e   McClelland, Michael ^b   Adamson, Eileen ^a   Mercola, Dan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

^c EGE UNIVERSITY   (Turkey)

^d BURNHAM INSTITUTE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MAX PROTEIN; P21 ACTIVATED KINASE 6; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL GROWTH; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROMOTER REGION; PROSTATE CANCER; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ULTRAVIOLET IRRADIATION; CELL LINE; GENE EXPRESSION PROFILING; GENETICS; MALE; METABOLISM; PROSTATE TUMOR; RADIATION EXPOSURE; TRANSCRIPTION INITIATION; ULTRAVIOLET RADIATION;

APOPTOSIS; CELL LINE, TRANSFORMED; CHROMATIN IMMUNOPRECIPITATION; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; TRANSCRIPTIONAL ACTIVATION; ULTRAVIOLET RAYS;

EID: 57649203370     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2008-9-11-r166     Document Type: Article

References (48)

1. Sukhatme VP Cao XM Chang LC Tsai-Morris CH Stamenkovich D Ferreira PC Cohen DR Edwards SA Shows TB Curran T A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 1988, 53:37-43. 10.1016/ 0092-8674(88)90485-0 3127059
2. Baron V Adamson ED Calogero A Ragona G Mercola D The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 2006, 13:115-124. 2455793 16138117 10.1038/sj.cgt.7700896
3. Call KM Glaser T Ito CY Buckler AJ Pelletier J Haber DA Rose EA Kral A Yeger H Lewis WH Jones C Housman DE Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990, 60:509-520. 10.1016/0092-8674(90)90601-A 2154335
4. Milbrandt J A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 1987, 238:797-799. 10.1126/ science.3672127 3672127
5. Bernstein SH Kharbanda SM Sherman ML Sukhatme VP Kufe DW Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage colony-stimulating factor in human U-937 monocytic leukemia cells: Involvement of a pertussis toxin-sensitive G protein. Cell Growth Differ 1991, 2:273-278. 2064996
6. McLaughlin JN Mazzoni MR Cleator JH Earls L Perdigoto AL Brooks JD Muldowney JA 3rd Vaughan DE Hamm HE Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J Biol Chem 2005, 280:22172-22180. 10.1074/ jbc.M500721200 15817447
7. Ghazvini-Boroujerdi M Clark J Narula N Palmatory E Connolly JM DeFelice S Xu J Jian B Hazelwood S Levy RJ Transcription factor Egr1 in calcific aortic valve disease. J Heart Valve Dis 2004, 13:894-903. 15597579
8. Lee CG Cho SJ Kang MJ Chapoval SP Lee PJ Noble PW Yehualaeshet T Lu B Flavell RA Milbrandt J Homer RJ Elias JA Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004, 200:377-389. 2211975 15289506 10.1084/jem.20040104
9. Levin WJ Press MF Gaynor RB Sukhatme VP Boone TC Reissmann PT Figlin RA Holmes EC Souza LM Slamon DJ Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group. Oncogene 1995, 11:1261-1269. 7478546
10. Calogero A Arcella A De Gregorio G Porcellini A Mercola D Liu C Lombari V Zani M Giannini G Gagliardi FM Caruso R Gulino A Frati L Ragano G The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. Clin Cancer Res 2001, 7:2788-2796. 11555594
11. Joslin JM Fernald AA Tennant TR Davis EM Kogan SC Anastasi J Crispino JD Le Beau MM Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 2007, 110:719-726. 1924479 17420284 10.1182/blood-2007-01-068809
12. Svaren J Ehrig T Abdulkadir SA Ehrengruber MU Watson MA Milbrandt J EGR1 target genes in prostate carcinoma cells identified by microarray analysis. J Biol Chem 2000, 275:38524-38531. 10.1074/jbc.M005220200 10984481
13. Baron V De Gregorio G Krones-Herzig A Virolle T Calogero A Urcis R Mercola D Inhibition of Egr1 expression reverses transformation of prostate cancer cells in vitro and in vivo. Oncogene 2003, 22:4194-4204. 10.1038/sj.onc.1206560 12833142
14. Abdulkadir SA Mechanisms of prostate tumorigenesis: Roles for transcription factors Nkx3.1 and Egr1. Ann NY Acad Sci 2005, 1059:33-40. 10.1196/annals.1339.018 16382041
15. Mora GR Olivier KR Cheville JC Mitchell RF Jr Lingle WL Tindall DJ The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate. Mol Cancer Res 2004, 2:115-128. 14985468
16. Datta R Rubin E Sukhatme V Qureshi S Hallahan D Weichselbaum RR Kufe DW Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc Natl Acad Sci USA 1992, 89:10149-10153. 50295 1332031 10.1073/pnas.89.21.10149
17. Lange-Carter CA Johnson GL Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 1994, 265:1458-1461. 10.1126/ science.8073291 8073291
18. Al-Sarraj A Thiel G The zinc finger transcription factor Egr1 is up-regulated in arsenite-treated human keratinocytes. J Mol Med 2004, 82:530-538. 10.1007/s00109-004-0545-0 15292961
19. Oosterhoff JK Kuhne LC Grootegoed JA Blok LJ EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. Int J Cancer 2005, 113:561-567. 10.1002/ ijc.20612 15455380
20. El-Abaseri TB Fuhrman J Trempus C Shendrik I Tennant RW Hansen LA Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor. Cancer Res 2005, 65:3958-3965. 10.1158/0008-5472.CAN-04-2204 15867397
21. Huang RP Wu JX Fan Y Adamson ED UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 1996, 133:211-220. 2120786 8601609 10.1083/jcb.133.1.211
22. Dikic I Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans 2003, 31:1178-1181. 14641021
23. Plymate SR Tennant M Birnbaum RS Thrasher JB Chatta G Ware JL The effect on the insulin-like growth factor system in human prostate epithelial cells of immortalization and transformation by simian virus-40 T antigen. J Clin Endocrinol Metab 1996, 81:3709-3716. 10.1210/ jc.81.10.3709 8855827
24. Hayakawa J Mittal S Wang Y Korkmaz KS Adamson E English C Ohmichi M McClelland M Mercola D Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell 2004, 16:521-535. 10.1016/j.molcel.2004.10.024 15546613
25. McClelland M Ivarie R Asymmetrical distribution of CpG in an 'average' mammalian gene. Nucleic Acids Res 1982, 10:7865-7877. 327052 7155899 10.1093/nar/10.23.7865
26. Jin W Riley RM Wolfinger RD White KP Passador-Gurgel G Gibson G The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nat Genet 2001, 29:389-395. 10.1038/ng766 11726925
27. Roberts PJ Der CJ Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26:3291-3310. 10.1038/sj.onc.1210422 17496923
28. Kaufmann K Thiel G Epidermal growth factor and platelet-derived growth factor induce expression of Egr1, a zinc finger transcription factor, in human malignant glioma cells. J Neurol Sci 2001, 189:83-91. 10.1016/ S0022-510X(01)00562-7 11535237
29. Seo M Lee MJ Heo JH Lee YI Kim Y Kim SY Lee ES Juhnn YS G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. J Biol Chem 2007, 282:24720-24730. 10.1074/jbc.M702343200 17548351
30. Perini G Diolaiti D Porro A Della Valle G In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation. Proc Natl Acad Sci USA 2005, 102:12117-12122. 1184034 16093321 10.1073/ pnas.0409097102
31. Roelle S Grosse R Aigner A Krell HW Czubayko F Gudermann T Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone. J Biol Chem 2003, 278:47307-47318. 10.1074/jbc.M304377200 12963732
32. Ahmed MM Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Curr Cancer Drug Targets 2004, 4:43-52. 10.2174/1568009043481704 14965266
33. Reinehr R Becker S Eberle A Grether-Beck S Haussinger D Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem 2005, 280:27179-27194. 10.1074/ jbc.M414361200 15917250
34. Steinbach JP Eisenmann C Klumpp A Weller M Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. Biochem Biophys Res Commun 2004, 321:524-530. 10.1016/ j.bbrc.2004.06.175 15358139
35. Li-Weber M Laur O Krammer PH Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation. Eur J Immunol 1999, 29:3017-3027. 10.1002/ (SICI)1521-4141(199909)29:09<3017::AID-IMMU3017>3.0.CO;2-R 10508276
36. Baron V Duss S Rhim J Mercola D Antisense to the early growth response-1 gene (Egr1) inhibits prostate tumor development in TRAMP mice. Ann NY Acad Sci 2003, 1002:197-216. 10.1196/annals.1281.024 14751836
37. Yu J de Belle I Liang H Adamson ED Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell 2004, 15:83-94. 10.1016/ j.molcel.2004.06.030 15225550
38. Yu J Baron V Mercola D Mustelin T Adamson ED A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ 2007, 14:436-446. 10.1038/sj.cdd.4402029 16990849
39. Tikhomirov O Carpenter G Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci 2005, 118:5681-5690. 10.1242/jcs.02676 16303853
40. Bellot G Cartron PF Er E Oliver L Juin P Armstrong LC Bornstein P Mihara K Manon S Vallette FM TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ 2007, 14:785-794. 10.1038/ sj.cdd.4402055 17096026
41. Rong R He Q Liu Y Sheikh MS Huang Y TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. Oncogene 2002, 21:1062-1070. 10.1038/ sj.onc.1205154 11850823
42. de Belle I Mercola D Adamson ED Method for cloning in vivo targets of the Egr1 transcription factor. Biotechniques 2000, 29:162-169. 10907091
43. Hoemme C Peerzada A Behre G Wang Y McClelland M Nieselt K Zschunke M Disselhoff C Agrawal S Isken F Tidow N Berdel WE Serve H Muller-Tidow C Chromatin modifications induced by PML-RAR{alpha} repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood 2008, 111:2887-2895. 10.1182/blood-2007-03-079921 18024792
44. Human Promoter Array http://bioinformatics.skcc.org/array
45. Wang Y Hayakawa J Long F Yu Q Cho AH Rondeau G Welsh J Mittal S De Belle I Adamson E McClelland M Mercola D "Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells. Ann N Y Acad Sci 2005, 1058:162-185. 10.1196/annals.1359.024 16394135
46. Smyth GK Speed T Normalization of cDNA microarray data. Methods 2003, 31:265-273. 10.1016/S1046-2023(03)00155-5 14597310
47. DNA Microarray Software and Server http://www.igb.uci.edu/servers/ dmss.html
48. TESS software http://www.cbil.upenn.edu/cgi-bin/tess/tess