EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2

International Journal of Cancer

Volumn 113, Issue 4, 2005, Pages 561-567

  Oosterhoff, Josien K ^a   Kühne, Liesbeth C ^a   Grootegoed, J Anton ^a   Blok, Leen J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

EGF signalling; Endocytosis; Prostate cancer; REPS2

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PROTEIN; PROTEIN C JUN; PROTEIN FOS; RALBP1 ASSOCIATED EPS DOMAIN CONTAINING PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANDROGENS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMEDIATE-EARLY PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEOPLASMS, HORMONE-DEPENDENT; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 11144332921     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20612     Document Type: Article

References (28)

1. Russell PJ, Bennett S, Stricker P. Growth factor involvement in progression of prostate cancer. Clin Chem 1998;44:705-23.
2. Scher HI, Sarkis A, Reuter V, Cohen D, Netto G, Petrylak D, Lianes P, Fuks Z, Mendelsohn J, Cordon-Cardo C. Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms. Clin Cancer Res 1995;1:545-50.
3. Jones JT, Akita RW, Sliwkowski MX. Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett 1999;447:227-31.
4. Gullick WJ, Srinivasan R. The type 1: growth factor receptor family: new ligands and receptors and their role in breast cancer. Breast Cancer Res Treat 1998;52:43-53.
5. Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001;37:S3-S8.
6. Seth D, Shaw K, Jazayeri J, Leedman PJ. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells. Br J Cancer 1999;80:657-69.
7. Waterman H, Yarden Y. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett 2001;490:142-52.
8. Di Fiore PP, Gill GN. Endocytosis and mitogenic signaling. Curr Opin Cell Biol 1999;11:483-8.
9. Ceresa BP, Schmid SL. Regulation of signal transduction by endocytosis. Curr Opin Cell Biol 2000;12:204-10.
10. Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. J Biol Chem 1998;273:814-21.
11. Kariya K, Koyama S, Nakashima S, Oshiro T, Morinaka K, Kikuchi A. Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation. J Biol Chem 2000;275:18399-406.
12. Martinu L, Santiago-Walker A, Qi H, Chou MM. Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. J Biol Chem 2002;277:50996-1002.
13. Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. Embo J 1999;18:3629-42.
14. Chang GT, Blok LJ, Steenbeek M, Veldscholte J, van Weerden WM, van Steenbrugge GJ, Brinkmann AO. Differentially expressed genes in androgen-dependent and -independent prostate carcinomas. Cancer Res 1997;57:4075-81.
15. Oosterhoff JK, Penninkhof F, Brinkmann AO, Anton Grootegoed J, Blok LJ. REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells. Oncogene 2003;22:2920-5.
16. Blok LJ, De Ruiter PE, Kuhne EC, Hanekamp EE, Grootegoed JA, Smid-Koopman E, Gielen SC, De Gooyer ME, Kloosterboer HJ, Burger CW. Progestogenic effects of tibolone on human endometrial cancer cells. J Clin Endocrinol Metab 2003;88:2327-34.
17. Saez E, Nelson MC, Eshelman B, Banayo E, Koder A, Cho GJ, Evans RM. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proc Natl Acad Sci U S A 2000;97:14512-7.
18. He YY, Huang JL, Gentry JB, Chignell CF. Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity. J Biol Chem 2003;278:42457-65.
19. Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K, Pienta KJ, Rubin MA, Chinnaiyan AM. Delineation of prognostic biomarkers in prostate cancer. Nature 2001;412:822-6.
20. Wiley HS, Herbst JJ, Walsh BJ, Lauffenburger DA, Rosenfeld MG, Gill GN. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J Biol Chem 1991;266:11083-94.
21. Vieira AV, Lamaze C, Schmid SL. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 1996;274:2086-9.
22. Pearse BM, Smith CJ, Owen DJ. Clathrin coat construction in endocytosis. Curr Opin Struct Biol 2000;10:220-8.
23. Jiang X, Huang F, Marusyk A, Sorkin A. Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell 2003;14:858-70.
24. Burke PM, Wiley HS. Human mammary epithelial cells rapidly exchange empty EGFR between surface and intracellular pools. J Cell Physiol 1999;180:448-60.
25. Jiang X, Sorkin A. Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell 2002;13:1522-35.
26. Oksvold MP, Skarpen E, Lindeman B, Roos N, Huitfeldt HS. Immunocytochemical localization of Shc arid activated EGF receptor in early endosomes after EGF stimulation of HeLa cells. J Histochem Cytochem 2000;48:21-33.
27. Oksvold MP, Skarpen E, Wierod L, Paulsen RE, Huitfeldt HS. Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF. Eur J Cell Biol 2001;80:285-94.
28. Floyd S, De Camilli P. Endocytosis proteins and cancer: a potential link? Trends Cell Biol 1998;8:299-301.