Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor

Cancer Research

Volumn 65, Issue 9, 2005, Pages 3958-3965

  El Abaseri, Taghrid B ^a   Fuhrman, Jill ^a   Trempus, Carol ^b   Shendrik, Igor ^a   Tennant, Raymond W ^b   Hansen, Laura A ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; DIMETHYL SULFOXIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; EPIDERMIS HYPERPLASIA; GROWTH INHIBITION; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN CANCER; SKIN CARCINOGENESIS; TARGET CELL; TRANSGENIC MOUSE; TUMOR GROWTH; ULTRAVIOLET RADIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTICARCINOGENIC AGENTS; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPERPLASIA; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; NEOPLASMS, RADIATION-INDUCED; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SKIN; SKIN NEOPLASMS; TYRPHOSTINS; ULTRAVIOLET RAYS;

EID: 18144371160     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2204     Document Type: Article

References (44)

1. Matsumura Y, Ananthaswamy HN. Molecular mechanisms of photocarcinogenesis. Front Biosci 2002;7:d765-83.
2. Devary Y, Gottlieb RA, Smeal T, Karin M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 1992;71:1081-91.
3. Devary Y, Rosette C, DiDonato JA, Karin M. NF-κB activation by ultraviolet light not dependent on a nuclear signal. Science 1993;261:1442-5.
4. Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 1996;274:1194-7.
5. Kyriakis JM, Avruch J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 1996;18:567-77.
6. Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J 1996;15:5314-25.
7. Huang RP, Wu JX, Fan Y, Adamson ED. UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 1996;133:211-20.
8. Ley KD, Ellem KA. UVC modulation of epidermal growth factor receptor number in HeLa S3 cells. Carcinogenesis 1992;13:183-7.
9. Kitagawa D, Tanemura S, Ohata S, et al. Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function. J Biol Chem 2002;277:366-71.
10. Iordanov MS, Choi RJ, Ryabinina OP, Dinh TH, Bright RK, Magun BE. The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol Cell Biol 2002;22:5380-94.
11. Dlugosz AA, Hansen L, Cheng C, et al. Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-rasHa oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Res 1997;57:3180-8.
12. Vassar R, Fuchs E. Transgenic mice provide new insights into the role of TGF-a during epidermal development and differentiation. Genes Dev 1991;5:714-27.
13. Hunts J, Ueda M, Ozawa S, Abe O, Pastan I, Shimizu N. Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomas. Jpn J Cancer Res 1985;76:663-6.
14. Lee DC, Luetteke NC, Petch LA. Transforming growth factor-α and its role in neoplastic progression. Cancer Treat Res 1992;63:233-54.
15. Leder A, Kuo A, Cardiff RD, Sinn E, Leder P. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci U S A 1990;87:9178-82.
16. Tennant RW, Spalding J, French JE. Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens. Mutat Res 1996;365:119-27.
17. Trempus CS, Mahler JF, Ananthaswamy HN, Loughlin SM, French JE, Tennant RW. Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg.AC mouse. J Invest Dermatol 1998;111:445-51.
18. Ananthaswamy HN, Pierceall WE. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol 1990;52:1119-36.
19. Arteaga CL. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001;19:32-40S.
20. Threadgill DW, Dlugosz AA, Hansen LA, et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995;269:230-4.
21. Hansen LA, Lichti U, Tennenbaum T, et al. Altered hair follicle morphogenesis in epidermal growth factor receptor deficient mice. In: Van Nestefs DJJ, Randall VA, editors. Hair research for the next millenium. Amsterdam: Elsevier Science B.V.; 1996. p. 425-31.
22. Hansen LA, Monteiro-Riviere NA, Smart RC. Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion. Cancer Res 1990;50:5740-5.
23. Morris RJ, Fischer SM, Klein-Szanto AJ, Slaga TJ. Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients. Cell Tissue Kinet 1990;23:587-602.
24. Hansen LA, Malarkey DE, Wilkinson JE, Rosenberg M, Woychik RE, Tennant RW. Effect of the viable-yellow (A(vy)) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TGxAC mice. Carcinogenesis 1998;19:1837-45.
25. Assefa Z, Garmyn M, Bouillon R, Merlevede W, Vandenheede JR, Agostinis P. Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes. J Invest Dermatol 1997;108:886-91.
26. Ramaswamy NT, Ronai Z, Pelling JC. Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes. Oncogene 1998;16:1501-5.
27. Dhanwada KR, Dickens M, Neades R, Davis R, Pelling JC. Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes. Oncogene 1995;11:1947-53.
28. Xi X, Han J, Zhang JZ. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J Biol Chem 2001;276:41029-34.
29. Wan YS, Wang ZQ, Shao Y, Voorhees JJ, Fisher GJ. Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo. Int J Oncol 2001;18:461-6.
30. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D, Ananthaswamy HN. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 2000;156:201-7.
31. Hansen LA, Alexander N, Hogan ME, et al. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol 1997;150:1959-75.
32. Sibilia M, Fleischmann A, Behrens A, et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 2000;102:211-20.
33. L. Oncogene 1998;16:1493-9.
34. L expression through a MEK-dependent pathway. J Biol Chem 2001;276:6320-6.
35. Suzuki A, Itami S, Ohishi M, et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 2003;63:674-81.
36. Kreimer-Erlacher H, Seidl H, Back B, Kerl H, Wolf P. High mutation frequency at Ha-ras exons 1-4 in squamous cell carcinomas from PUVA-treated psoriasis patients. Photochem Photobiol 2001;74:323-30.
37. de Vries A, Berg RJ, Wijnhoven S, et al. XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.B. Oncogene 1998;16:2205-12.
38. Dajee M, Lazarov M, Zhang JY, et al. NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 2003;421:639-43.
39. Lazarov M, Kubo Y, Cai T, et al. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat Med 2002;8:1105-14.
40. Weber A, Langhanki L, Sommerer F, Markwarth A, Wittekind C, Tannapfel A. Mutations of the BRAF gene in squamous cell carcinoma of the head and neck. Oncogene 2003;22:4757-9.
41. Salomon DS, Bianco C, De Santis M. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. Bioessays 1999;21:61-70.
42. Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999;59:1935-40.
43. Ciardiello F, Bianco R, Damiano V, et al. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res 1999;5:909-16.
44. Perrotte P, Matsumoto T, Inoue K, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999;5:257-65.