A chimeric protein C containing the prothrombin Gla domain exhibits increased anticoagulant activity and altered phospholipid specificity

Journal of Biological Chemistry

Volumn 273, Issue 15, 1998, Pages 9031-9040

  Smirnov, Mikhail D ^a   Safa, Omid ^a   Regan, Lisa ^b   Mather, Timothy ^a   Stearns Kurosawa, Deborah J ^a   Kurosawa, Shinichiro ^a   Rezaie, Alireza R ^a   Esmon, Naomi L ^a,c   Esmon, Charles T ^a,b,c,d  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CHIMERIC PROTEIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PROTEIN C; PROTEIN S; PROTHROMBIN;

ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; MOLECULAR INTERACTION; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTICOAGULANTS; ARGININE; CATTLE; DNA PRIMERS; FACTOR VA; HUMANS; KINETICS; LIPOSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLETHANOLAMINES; PROTEIN C; PROTEIN CONFORMATION; PROTHROMBIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN;

EID: 0032502796     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.15.9031     Document Type: Article

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