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Volumn 17, Issue 4, 2008, Pages 191-199

Mutations in myeloid neoplasms

Author keywords

FLT3; JAK2; KIT; Leukemia; MLL; Molecular; Mutations; NPM1

Indexed keywords

CD135 ANTIGEN; CORE BINDING FACTOR; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOPHOSMIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; RAS PROTEIN; STEM CELL FACTOR RECEPTOR; THROMBOPOIETIN RECEPTOR;

EID: 57649193204     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/PDM.0b013e31817d5327     Document Type: Review
Times cited : (1)

References (91)
  • 2
    • 0033765139 scopus 로고    scopus 로고
    • The incidences of trisomy 8, trisomy 9 and D20S108 deletion in polycythaemia vera: An analysis of blood granulocytes using interphase fluorescence in situ hybridization
    • Westwood NB, Gruszka-Westwood AM, Pearson CE, et al. The incidences of trisomy 8, trisomy 9 and D20S108 deletion in polycythaemia vera: an analysis of blood granulocytes using interphase fluorescence in situ hybridization. Br J Haematol. 2000;110:839-846.
    • (2000) Br J Haematol , vol.110 , pp. 839-846
    • Westwood, N.B.1    Gruszka-Westwood, A.M.2    Pearson, C.E.3
  • 3
    • 0011280342 scopus 로고
    • Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction
    • Wilks AF. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci USA. 1989;86:1603-1607.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1603-1607
    • Wilks, A.F.1
  • 4
    • 39649099388 scopus 로고    scopus 로고
    • A role for JAK2 mutations in myeloproliferative diseases
    • Morgan KJ, Gilliland DG. A role for JAK2 mutations in myeloproliferative diseases. Annu Rev Med. 2008;59:213-222.
    • (2008) Annu Rev Med , vol.59 , pp. 213-222
    • Morgan, K.J.1    Gilliland, D.G.2
  • 5
    • 34848840612 scopus 로고    scopus 로고
    • Advances in the molecular characterization of Philadelphia-negative chronic myeloproliferative disorders
    • Pikman Y, Levine RL. Advances in the molecular characterization of Philadelphia-negative chronic myeloproliferative disorders. Curr Opin Oncol. 2007;19:628-634.
    • (2007) Curr Opin Oncol , vol.19 , pp. 628-634
    • Pikman, Y.1    Levine, R.L.2
  • 6
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-1790.
    • (2005) N Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 7
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
    • Jelinek J, Oki Y, Gharibyan V, et al. JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood. 2005;106:3370-3373.
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3
  • 8
    • 34548128326 scopus 로고    scopus 로고
    • Prevalence and clinico-pathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera
    • Pardanani A, Lasho TL, Finke C, et al. Prevalence and clinico-pathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia. 2007;21:1960-1963.
    • (2007) Leukemia , vol.21 , pp. 1960-1963
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3
  • 9
    • 37049039725 scopus 로고    scopus 로고
    • JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    • Barosi G, Bergamaschi G, Marchetti M, et al. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood. 2007;110:4030-4036.
    • (2007) Blood , vol.110 , pp. 4030-4036
    • Barosi, G.1    Bergamaschi, G.2    Marchetti, M.3
  • 10
    • 33846620183 scopus 로고    scopus 로고
    • Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation
    • Aboudola S, Murugesan G, Szpurka H, et al. Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation. Am J Surg Pathol. 2007;31:233-239.
    • (2007) Am J Surg Pathol , vol.31 , pp. 233-239
    • Aboudola, S.1    Murugesan, G.2    Szpurka, H.3
  • 11
    • 36248961144 scopus 로고    scopus 로고
    • Comparative evaluation of three JAK2V617F mutation detection methods
    • Frantz C, Sekora DM, Henley DC, et al. Comparative evaluation of three JAK2V617F mutation detection methods. Am J Clin Pathol. 2007;128:865-874.
    • (2007) Am J Clin Pathol , vol.128 , pp. 865-874
    • Frantz, C.1    Sekora, D.M.2    Henley, D.C.3
  • 12
    • 33748592820 scopus 로고    scopus 로고
    • JAK2 V617F in myeloid disorders: Molecular diagnostic techniques and their clinical utility: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology
    • quiz 526
    • Steensma DP. JAK2 V617F in myeloid disorders: molecular diagnostic techniques and their clinical utility: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology. J Mol Diagn. 2006;8:397-411; quiz 526.
    • (2006) J Mol Diagn , vol.8 , pp. 397-411
    • Steensma, D.P.1
  • 13
    • 34548042964 scopus 로고    scopus 로고
    • Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
    • Tefferi A, Thiele J, Orazi A, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007;110:1092-1097.
    • (2007) Blood , vol.110 , pp. 1092-1097
    • Tefferi, A.1    Thiele, J.2    Orazi, A.3
  • 14
    • 1942467418 scopus 로고    scopus 로고
    • Thrombopoietin receptor (Mpl) expression by megakaryocytes in myeloproliferative disorders
    • Bock O, Schlue J, Mengel M, et al. Thrombopoietin receptor (Mpl) expression by megakaryocytes in myeloproliferative disorders. J Pathol. 2004;203:609-615,
    • (2004) J Pathol , vol.203 , pp. 609-615
    • Bock, O.1    Schlue, J.2    Mengel, M.3
  • 15
    • 33845239214 scopus 로고    scopus 로고
    • Molecular mimicry in the chronic myeloproliferative disorders: Reciprocity between quantitative JAK2 V617F and Mpl expression
    • Moliterno AR, Williams DM, Rogers O, et al. Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression. Blood. 2006;108:3913-3915.
    • (2006) Blood , vol.108 , pp. 3913-3915
    • Moliterno, A.R.1    Williams, D.M.2    Rogers, O.3
  • 16
    • 0030732423 scopus 로고    scopus 로고
    • Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia
    • Horikawa Y, Matsumura I, Hashimoto K, et al. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood. 1997;90:4031-4038.
    • (1997) Blood , vol.90 , pp. 4031-4038
    • Horikawa, Y.1    Matsumura, I.2    Hashimoto, K.3
  • 17
    • 36348999273 scopus 로고    scopus 로고
    • Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
    • Chaligne R, James C, Tonetti C, et al. Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Blood. 2007;110:3735-3743.
    • (2007) Blood , vol.110 , pp. 3735-3743
    • Chaligne, R.1    James, C.2    Tonetti, C.3
  • 18
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T, et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006;108:3472-3476.
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3
  • 19
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270.
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 20
    • 2642609475 scopus 로고    scopus 로고
    • Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera
    • Moliterno AR, Hankins WD, Spivak JL. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. N Engl J Med. 1998;338:572-580.
    • (1998) N Engl J Med , vol.338 , pp. 572-580
    • Moliterno, A.R.1    Hankins, W.D.2    Spivak, J.L.3
  • 22
    • 0842310394 scopus 로고    scopus 로고
    • The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
    • Griffith J, Black J, Faerman C, et al. The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell. 2004;13:169-178.
    • (2004) Mol Cell , vol.13 , pp. 169-178
    • Griffith, J.1    Black, J.2    Faerman, C.3
  • 23
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: The combination matters-an analysis of 3082 patients
    • Bacher U, Haferlach C, Kern W, et al. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters-an analysis of 3082 patients. Blood. 2008;111:2527-2537.
    • (2008) Blood , vol.111 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3
  • 24
    • 33644782618 scopus 로고    scopus 로고
    • D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias
    • Schnittger S, Kohl TM, Leopold N, et al. D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias. Genes Chromosomes Cancer. 2006;45:332-337.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 332-337
    • Schnittger, S.1    Kohl, T.M.2    Leopold, N.3
  • 25
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 26
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 27
    • 9144269029 scopus 로고    scopus 로고
    • FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
    • Zheng R, Levis M, Piloto O, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004;103:267-274.
    • (2004) Blood , vol.103 , pp. 267-274
    • Zheng, R.1    Levis, M.2    Piloto, O.3
  • 28
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 29
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3
  • 30
    • 1542276560 scopus 로고    scopus 로고
    • FLT3 mutations in childhood acute lymphoblastic leukemia
    • Armstrong SA, Mabon ME, Silverman LB, et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004;103:3544-3546.
    • (2004) Blood , vol.103 , pp. 3544-3546
    • Armstrong, S.A.1    Mabon, M.E.2    Silverman, L.B.3
  • 31
    • 0141482006 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: Prognostic significance and relation to cellular drug resistance
    • Zwaan CM, Meshinchi S, Radich JP, et al. FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. Blood. 2003;102:2387-2394.
    • (2003) Blood , vol.102 , pp. 2387-2394
    • Zwaan, C.M.1    Meshinchi, S.2    Radich, J.P.3
  • 32
    • 33645312560 scopus 로고    scopus 로고
    • Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML
    • Reindl C, Bagrintseva K, Vempati S, et al. Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood. 2006;107:3700-3707.
    • (2006) Blood , vol.107 , pp. 3700-3707
    • Reindl, C.1    Bagrintseva, K.2    Vempati, S.3
  • 33
    • 33845254595 scopus 로고    scopus 로고
    • Clinical implications of FLT3 mutations in pediatric AML
    • Meshinchi S, Alonzo TA, Stirewalt DL, et al. Clinical implications of FLT3 mutations in pediatric AML. Blood. 2006;108:3654-3661.
    • (2006) Blood , vol.108 , pp. 3654-3661
    • Meshinchi, S.1    Alonzo, T.A.2    Stirewalt, D.L.3
  • 34
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106:3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 35
    • 38949212204 scopus 로고    scopus 로고
    • FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications
    • Whitman SP, Ruppert AS, Radmacher MD, et al. FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. Blood. 2008;111:1552-1559.
    • (2008) Blood , vol.111 , pp. 1552-1559
    • Whitman, S.P.1    Ruppert, A.S.2    Radmacher, M.D.3
  • 36
    • 24944590535 scopus 로고    scopus 로고
    • Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3
    • Mills KI, Gilkes AF, Walsh V, et al. Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3. Br J Haematol. 2005;130:203-208.
    • (2005) Br J Haematol , vol.130 , pp. 203-208
    • Mills, K.I.1    Gilkes, A.F.2    Walsh, V.3
  • 37
    • 4344610322 scopus 로고    scopus 로고
    • High-resolution melting analysis for detection of internal tandem duplications
    • Vaughn CP, Elenitoba-Johnson KS. High-resolution melting analysis for detection of internal tandem duplications. J Mol Diagn. 2004;6:211-216.
    • (2004) J Mol Diagn , vol.6 , pp. 211-216
    • Vaughn, C.P.1    Elenitoba-Johnson, K.S.2
  • 38
    • 4644220954 scopus 로고    scopus 로고
    • MLL: A histone methyltransferase disrupted in leukemia
    • Hess JL. MLL: a histone methyltransferase disrupted in leukemia. Trends Mol Med. 2004;10:500-507.
    • (2004) Trends Mol Med , vol.10 , pp. 500-507
    • Hess, J.L.1
  • 39
    • 0026936328 scopus 로고
    • A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
    • Djabali M, Selleri L, Parry P, et al. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet. 1992;2:113-118.
    • (1992) Nat Genet , vol.2 , pp. 113-118
    • Djabali, M.1    Selleri, L.2    Parry, P.3
  • 40
    • 0025833975 scopus 로고
    • Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
    • Ziemin-van der Poel S, McCabe NR, Gill HJ, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA. 1991;88:10735-10739.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10735-10739
    • Ziemin-van der Poel, S.1    McCabe, N.R.2    Gill, H.J.3
  • 41
    • 33748178469 scopus 로고    scopus 로고
    • Chromosomal translocations involving the MLL gene: Molecular mechanisms
    • Aplan PD. Chromosomal translocations involving the MLL gene: molecular mechanisms. DNA Repair (Amst). 2006;5:1265-1272.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 1265-1272
    • Aplan, P.D.1
  • 42
    • 35348849015 scopus 로고    scopus 로고
    • Hox genes in hematopoiesis and leukemogenesis
    • Argiropoulos B, Humphries RK. Hox genes in hematopoiesis and leukemogenesis. Oncogene. 2007;26:6766-6776.
    • (2007) Oncogene , vol.26 , pp. 6766-6776
    • Argiropoulos, B.1    Humphries, R.K.2
  • 43
    • 33846582947 scopus 로고    scopus 로고
    • The role of HOX genes in malignant myeloid disease
    • Eklund EA. The role of HOX genes in malignant myeloid disease. Curr Opin Hematol. 2007;14:85-89.
    • (2007) Curr Opin Hematol , vol.14 , pp. 85-89
    • Eklund, E.A.1
  • 44
    • 0028869112 scopus 로고
    • Altered Hox expression and segmental identity in Mil-mutant mice
    • Yu BD, Hess JL, Horning SE, et al. Altered Hox expression and segmental identity in Mil-mutant mice. Nature. 1995;378:505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3
  • 45
    • 9244257908 scopus 로고    scopus 로고
    • An Mll-dependent Hox program drives hematopoietic progenitor expansion
    • Ernst P, Mabon M, Davidson AJ, et al. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004;14:2063-2069.
    • (2004) Curr Biol , vol.14 , pp. 2063-2069
    • Ernst, P.1    Mabon, M.2    Davidson, A.J.3
  • 46
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer. 2007;7:823-833.
    • (2007) Nat Rev Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 47
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 48
    • 0028084756 scopus 로고
    • Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations
    • Caligiuri MA, Schichman SA, Strout MP, et al. Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations. Cancer Res. 1994;54:370-373.
    • (1994) Cancer Res , vol.54 , pp. 370-373
    • Caligiuri, M.A.1    Schichman, S.A.2    Strout, M.P.3
  • 49
    • 33750087521 scopus 로고    scopus 로고
    • The MLL partial tandem duplication in acute myeloid leukaemia
    • Basecke J, Whelan JT, Griesinger F, et al. The MLL partial tandem duplication in acute myeloid leukaemia. Br J Haematol. 2006;135:438-449.
    • (2006) Br J Haematol , vol.135 , pp. 438-449
    • Basecke, J.1    Whelan, J.T.2    Griesinger, F.3
  • 50
    • 0036682174 scopus 로고    scopus 로고
    • Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: A study of the Acute Myeloid Leukemia Study Group Ulm
    • Dohner K, Tobis K, Ulrich R, et al. Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J Clin Oncol. 2002;20:3254-3261.
    • (2002) J Clin Oncol , vol.20 , pp. 3254-3261
    • Dohner, K.1    Tobis, K.2    Ulrich, R.3
  • 51
    • 0032519826 scopus 로고    scopus 로고
    • Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: Distinct origin of normal versus leukemic ALL1 fusion transcripts
    • Marcucci G, Strout MP, Bloomfield CD, et al. Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: distinct origin of normal versus leukemic ALL1 fusion transcripts. Cancer Res. 1998;58:790-793.
    • (1998) Cancer Res , vol.58 , pp. 790-793
    • Marcucci, G.1    Strout, M.P.2    Bloomfield, C.D.3
  • 52
    • 22644443959 scopus 로고    scopus 로고
    • Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy
    • Weisser M, Kern W, Schoch C, et al. Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy. Haematologica. 2005;90:881-889.
    • (2005) Haematologica , vol.90 , pp. 881-889
    • Weisser, M.1    Kern, W.2    Schoch, C.3
  • 53
    • 34547676848 scopus 로고    scopus 로고
    • Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
    • Falini B, Nicoletti I, Bolli N, et al. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica. 2007;92:519-532.
    • (2007) Haematologica , vol.92 , pp. 519-532
    • Falini, B.1    Nicoletti, I.2    Bolli, N.3
  • 54
    • 0023764934 scopus 로고
    • DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23
    • Schmidt-Zachmann MS, Franke WW. DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23. Chromosoma. 1988;96:417-426.
    • (1988) Chromosoma , vol.96 , pp. 417-426
    • Schmidt-Zachmann, M.S.1    Franke, W.W.2
  • 55
    • 33750601863 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations in acute myeloid leukemia
    • Chen W, Rassidakis GZ, Medeiros LJ. Nucleophosmin gene mutations in acute myeloid leukemia. Arch Pathol Lab Med. 2006;130:1687-1692.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1687-1692
    • Chen, W.1    Rassidakis, G.Z.2    Medeiros, L.J.3
  • 56
    • 0034663029 scopus 로고    scopus 로고
    • Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): Results of the European Working Party. Groupe Francais de Cytogenetique Hematologique, Groupe de Francais d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action Molecular Cytogenetic Diagnosis in Haematological Malignancies
    • Grimwade D, Biondi A, Mozziconacci MJ, et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Francais de Cytogenetique Hematologique, Groupe de Francais d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies." Blood. 2000;96:1297-1308.
    • (2000) Blood , vol.96 , pp. 1297-1308
    • Grimwade, D.1    Biondi, A.2    Mozziconacci, M.J.3
  • 57
    • 0033590608 scopus 로고    scopus 로고
    • Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia
    • Hummel JL, Wells RA, Dube ID, et al. Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia. Oncogene. 1999;18:633-641.
    • (1999) Oncogene , vol.18 , pp. 633-641
    • Hummel, J.L.1    Wells, R.A.2    Dube, I.D.3
  • 58
    • 0030022316 scopus 로고    scopus 로고
    • The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion
    • Redner RL, Rush EA, Faas S, et al. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood. 1996;87:882-886.
    • (1996) Blood , vol.87 , pp. 882-886
    • Redner, R.L.1    Rush, E.A.2    Faas, S.3
  • 59
    • 31444446824 scopus 로고    scopus 로고
    • Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): A comparison with NPMc+ AML
    • Falini B, Bigerna B, Pucciarini A, et al. Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): a comparison with NPMc+ AML. Leukemia. 2006;20:368-371.
    • (2006) Leukemia , vol.20 , pp. 368-371
    • Falini, B.1    Bigerna, B.2    Pucciarini, A.3
  • 60
    • 0024502495 scopus 로고
    • Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia
    • Raimondi SC, Dube ID, Valentine MB, et al. Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia. Leukemia. 1989;3:42-47.
    • (1989) Leukemia , vol.3 , pp. 42-47
    • Raimondi, S.C.1    Dube, I.D.2    Valentine, M.B.3
  • 61
    • 0030071926 scopus 로고    scopus 로고
    • The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
    • Yoneda-Kato N, Look AT, Kirstein MN, et al. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene. 1996;12:265-275.
    • (1996) Oncogene , vol.12 , pp. 265-275
    • Yoneda-Kato, N.1    Look, A.T.2    Kirstein, M.N.3
  • 62
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. JV
    • Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. JV Engl J Med. 2005;352:254-266.
    • (2005) Engl J Med , vol.352 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 63
    • 33748150899 scopus 로고    scopus 로고
    • High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei)
    • Chen W, Rassidakis GZ, Li J, et al. High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei). Blood. 2006;108:1783-1784.
    • (2006) Blood , vol.108 , pp. 1783-1784
    • Chen, W.1    Rassidakis, G.Z.2    Li, J.3
  • 64
    • 23744479178 scopus 로고    scopus 로고
    • Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype
    • Cazzaniga G, Dell'Oro MG, Mecucci C, et al. Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. Blood. 2005;106:1419-1422.
    • (2005) Blood , vol.106 , pp. 1419-1422
    • Cazzaniga, G.1    Dell'Oro, M.G.2    Mecucci, C.3
  • 65
    • 33645501151 scopus 로고    scopus 로고
    • Nucleophosmin mutations in de novo acute myeloid leukemia: The age-dependent incidences and the stability during disease evolution
    • Chou WC, Tang JL, Lin LI, et al. Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution. Cancer Res. 2006;66:3310-3316.
    • (2006) Cancer Res , vol.66 , pp. 3310-3316
    • Chou, W.C.1    Tang, J.L.2    Lin, L.I.3
  • 66
    • 34548501985 scopus 로고    scopus 로고
    • c-Kit - a hematopoietic cell essential receptor tyrosine kinase
    • Edling CE, Hallberg B. c-Kit - a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol. 2007;39:1995-1998.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1995-1998
    • Edling, C.E.1    Hallberg, B.2
  • 67
    • 2742529418 scopus 로고
    • Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
    • Yarden Y, Kuang WJ, Yang-Feng T, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. Embo J. 1987;6:3341-3351.
    • (1987) Embo J , vol.6 , pp. 3341-3351
    • Yarden, Y.1    Kuang, W.J.2    Yang-Feng, T.3
  • 68
    • 34250024319 scopus 로고    scopus 로고
    • Recent advances in the understanding of mastocytosis: The role of KIT mutations
    • Orfao A, Garcia-Montero AC, Sanchez L, et al. Recent advances in the understanding of mastocytosis: the role of KIT mutations. Br J Haematol. 2007;138:12-30.
    • (2007) Br J Haematol , vol.138 , pp. 12-30
    • Orfao, A.1    Garcia-Montero, A.C.2    Sanchez, L.3
  • 69
    • 0028890689 scopus 로고
    • The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction
    • Blechman JM, Lev S, Barg J, et al. The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell. 1995;80:103-113.
    • (1995) Cell , vol.80 , pp. 103-113
    • Blechman, J.M.1    Lev, S.2    Barg, J.3
  • 70
    • 27744551009 scopus 로고    scopus 로고
    • Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor
    • Roskoski R Jr. Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor. Biochem Biophys Res Commun. 2005;338:1307-1315.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 1307-1315
    • Roskoski Jr., R.1
  • 71
    • 25844507795 scopus 로고    scopus 로고
    • Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor
    • Roskoski R Jr. Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor. Biochem Biophys Res Commun. 2005;337:1-13.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 1-13
    • Roskoski Jr., R.1
  • 72
    • 0034608859 scopus 로고    scopus 로고
    • Crystal structure of human stem cell factor: Implication for stem cell factor receptor dimerization and activation
    • Zhang Z, Zhang R, Joachimiak A, et al. Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. Proc Natl Acad Sci USA. 2000;97:7732-7737.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7732-7737
    • Zhang, Z.1    Zhang, R.2    Joachimiak, A.3
  • 73
    • 0031924794 scopus 로고    scopus 로고
    • SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain
    • Kozlowski M, Larose L, Lee F, et al. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998;18:2089-2099.
    • (1998) Mol Cell Biol , vol.18 , pp. 2089-2099
    • Kozlowski, M.1    Larose, L.2    Lee, F.3
  • 74
    • 11144244315 scopus 로고    scopus 로고
    • Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
    • Zeng S, Xu Z, Lipkowitz S, et al. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood. 2005;105:226-232.
    • (2005) Blood , vol.105 , pp. 226-232
    • Zeng, S.1    Xu, Z.2    Lipkowitz, S.3
  • 76
    • 34547579487 scopus 로고    scopus 로고
    • Kit: Molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders
    • Patnaik MM, Tefferi A, Pardanani A. Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders. Curr Cancer Drug Targets. 2007;7:492-503.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 492-503
    • Patnaik, M.M.1    Tefferi, A.2    Pardanani, A.3
  • 77
    • 34147103980 scopus 로고    scopus 로고
    • The role of KIT in the management of patients with gastrointestinal stromal tumors
    • Hornick JL, Fletcher CD. The role of KIT in the management of patients with gastrointestinal stromal tumors. Hum Pathol. 2007;38:679-687.
    • (2007) Hum Pathol , vol.38 , pp. 679-687
    • Hornick, J.L.1    Fletcher, C.D.2
  • 79
    • 34548272148 scopus 로고    scopus 로고
    • KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities
    • Maric I, Robyn J, Metcalfe DD, et al. KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol. 2007;120:680-687.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 680-687
    • Maric, I.1    Robyn, J.2    Metcalfe, D.D.3
  • 80
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study
    • Paschka P, Marcucci G, Ruppert AS, et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol. 2006;24:3904-3911.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 81
    • 38449108455 scopus 로고    scopus 로고
    • Detection of the c-kit D816V mutation in systemic mastocytosis by allele-specific PCR
    • Schumacher JA, Elenitoba-Johnson KS, Lim MS. Detection of the c-kit D816V mutation in systemic mastocytosis by allele-specific PCR. J Clin Pathol. 2008;61:109-114.
    • (2008) J Clin Pathol , vol.61 , pp. 109-114
    • Schumacher, J.A.1    Elenitoba-Johnson, K.S.2    Lim, M.S.3
  • 82
    • 34249742721 scopus 로고    scopus 로고
    • Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma
    • Metzgeroth G, Walz C, Score J, et al. Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma. Leukemia. 2007;21:1183-1188.
    • (2007) Leukemia , vol.21 , pp. 1183-1188
    • Metzgeroth, G.1    Walz, C.2    Score, J.3
  • 83
    • 10744228486 scopus 로고    scopus 로고
    • CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
    • Pardanani A, Ketterling RP, Brockman SR, et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood. 2003;102:3093-3096.
    • (2003) Blood , vol.102 , pp. 3093-3096
    • Pardanani, A.1    Ketterling, R.P.2    Brockman, S.R.3
  • 84
    • 33846640626 scopus 로고    scopus 로고
    • Insight into the molecular pathogenesis of myeloid malignancies
    • Haferlach T, Bacher U, Haferlach C, et al. Insight into the molecular pathogenesis of myeloid malignancies. Curr Opin Hematol. 2007;14:90-97.
    • (2007) Curr Opin Hematol , vol.14 , pp. 90-97
    • Haferlach, T.1    Bacher, U.2    Haferlach, C.3
  • 85
    • 0033014304 scopus 로고    scopus 로고
    • RAS and leukemia: From basic mechanisms to gene-directed therapy
    • Beaupre DM, Kurzrock R. RAS and leukemia: from basic mechanisms to gene-directed therapy. J Clin Oncol. 1999;17:1071-1079.
    • (1999) J Clin Oncol , vol.17 , pp. 1071-1079
    • Beaupre, D.M.1    Kurzrock, R.2
  • 86
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O, et al. MAP kinase signalling pathways in cancer. Oncogene. 2007;26:3279-3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3
  • 87
    • 34547202520 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinase signaling in acute myeloid leukemia
    • Doepfner KT, Boller D, Arcaro A. Targeting receptor tyrosine kinase signaling in acute myeloid leukemia. Crit Rev Oncol Hematol. 2007;63:215-230.
    • (2007) Crit Rev Oncol Hematol , vol.63 , pp. 215-230
    • Doepfner, K.T.1    Boller, D.2    Arcaro, A.3
  • 88
    • 33646575624 scopus 로고    scopus 로고
    • Implications of NRAS mutations in AML: A study of 2502 patients
    • Bacher U, Haferlach T, Schoch C, et al. Implications of NRAS mutations in AML: a study of 2502 patients. Blood. 2006;107:3847-3853.
    • (2006) Blood , vol.107 , pp. 3847-3853
    • Bacher, U.1    Haferlach, T.2    Schoch, C.3
  • 89
    • 15044356744 scopus 로고    scopus 로고
    • CEBPalpha mutations in childhood acute myeloid leukemia
    • Liang DC, Shih LY, Huang CF, et al. CEBPalpha mutations in childhood acute myeloid leukemia. Leukemia. 2005;19:410-414.
    • (2005) Leukemia , vol.19 , pp. 410-414
    • Liang, D.C.1    Shih, L.Y.2    Huang, C.F.3
  • 90
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol. 2004;22:624-633.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3
  • 91
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, et al. Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol. 2005;23:6285-6295.
    • (2005) J Clin Oncol , vol.23 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3


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