High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei)

Blood

Volumn 108, Issue 5, 2006, Pages 1783-1784

  Chen, Weina ^a   Rassidakis, Georgios Z ^b   Li, Jiang ^b   Routbort, Mark ^b   Jones, Daniel ^b   Kantarjian, Hagop ^b   Medeiros, L Jeffrey ^a   Bueso Ramos, Carlos E ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPHOSMIN;

ACUTE GRANULOCYTIC LEUKEMIA; CARBOXY TERMINAL SEQUENCE; DISEASE CLASSIFICATION; ELECTRON MICROSCOPY; GENE MUTATION; HUMAN; INVAGINATION; LETTER; MEDICAL LITERATURE; MORPHOLOGY; PRIORITY JOURNAL;

EID: 33748150899     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-03-014340     Document Type: Letter

References (7)

1. Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352:254-266.
2. Falini B, Bolli N, Shan J, et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood. 2006;107:4514-4523. (Prepublished online February 2, 2006, as DOI 10.1182/blood-2005-11-4745.)
3. Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood. 2005;106:3733-3739.
4. Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106:3740-3746.
5. Alcalay M, Tiacci E, Bergomas R, et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood. 2005;106:899-902.
6. Kussick SJ, Stirewalt DL, Yi HS, et al. A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication. Leukemia. 2004;18:1591-1598.
7. Scott AA, Head DR, Kopecky KJ, et al. HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood. 1994;84:244-255.