Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin

Journal of Biological Chemistry

Volumn 283, Issue 44, 2008, Pages 30064-30072

  Schneider, Sarah ^a   Sandalova, Tatyana ^b   Schneider, Gunter ^b   Sprenger, Georg A ^a   Samland, Anne K ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; AMINES; AMINO ACIDS; ESCHERICHIA COLI; FRUCTOSE; ORGANIC ACIDS;

ACTIVE SITES; ALDOLASE; BOND PATTERNS; DIHYDROXYACETONE; MUTANT PROTEINS; MUTANT VARIANTS; POLYCLONAL ANTIBODIES; SCHIFF BASE; SEQUENCE ALIGNMENTS; STRUCTURAL STUDIES;

ANIMAL CELL CULTURE;

BACTERIAL ENZYME; DIHYDROXYACETONE; ERYTHROSE 4 PHOSPHATE; FRUCTOSE 6 PHOSPHATE; FRUCTOSE 6 PHOSPHATE ALDOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; PHENYLALANINE; PHOSPHATE; SCHIFF BASE; TRANSALDOLASE; TRANSALDOLASE TALB; TRANSALDOLASE TALDO1; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CELL-FREE SYSTEM; ESCHERICHIA COLI; FRUCTOSE-BISPHOSPHATE ALDOLASE; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; SEQUENCE HOMOLOGY, AMINO ACID; TRANSALDOLASE; TYROSINE;

ESCHERICHIA COLI;

EID: 57649143109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803184200     Document Type: Article

References (46)

1. Sprenger, G. A., Schörken, U., Sprenger, G., and Sahm, H. (1995) J. Bacteriol. 177, 5930-5936
2. Schneider, G., and Sprenger, G. A. (2002) Methods Enzymol. 354, 197-201
3. Schörken, U., Jia, J., Sahm, H., Sprenger, G. A., and Schneider, G. (1998) FEBS Lett. 441, 247-250
4. Schörken, U., Thorell, S., Schürmann, M., Jia, J., Sprenger, G. A., and Schneider, G. (2001) Eur. J. Biochem. 268, 2408-2415
5. Jia, J., Huang, W., Schörken, U., Sahm, H., Sprenger, G. A., Lindqvist, Y., and Schneider, G. (1996) Structure 4, 715-724
6. Jia, J., Schörken, U., Lindqvist, Y., Sprenger, G. A., and Schneider, G. (1997) Protein Sci. 6, 119-124
7. Thorell, S., Gergely, P., Jr., Banki, K., Perl, A., and Schneider, G. (2000) FEBS Lett. 475, 205-208
8. Schürmann, M., and Sprenger, G. A. (2001) J. Biol. Chem. 276, 11055-11061
9. Thorell, S., Schürmann, M., Sprenger, G. A., and Schneider, G. (2002) J. Mol. Biol. 319, 161-171
10. Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., and Horiuchi, T. (2006) Mol. Syst. Biol. 2, 2006 0007
11. Fürste, J. P., Pansegrau, W., Frank, R., Blöcker, H., Scholz, P., Bagdasarian, M., and Lanka, E. (1986) Gene (Amst.) 48, 119-131
12. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
13. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
14. Laemmli, U. K. (1970) Nature 227, 680-685
15. Inoue, T. (2006) Microbial Aldolases as C-C Bonding Enzymes: Investigations of Structural-Functional Characteristics and Application for Stereoselective Reactions, Ph.D. thesis, Universität Stuttgart, Stuttgart, Germany
16. Tsolas, O., and Horecker, B. L. (1972) The Enzymes, 3rd Ed., Academic Press, New York
17. Collaborative Computational Project, N. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
18. Vagin, A. A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1022-1025
19. Murshudov, G., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-253
20. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. Sect. D Biol. Crystallogr. 60, 2126-2132
21. Banki, K., Halladay, D., and Perl, A. (1994) J. Biol. Chem. 269, 2847-2851
22. Rosenberg, A. H., Lade, B. N., Chui, D. S., Lin, S. W., Dunn, J. J., and Studier, F. W. (1987) Gene (Amst.) 56, 125-135
23. Novy, R., Drott, D., Yaeger, K., and Mierendorf, R. (2001) inNovations 12, 1-3
24. Datsenko, K. A., and Wanner, B. L. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6640-6645
25. Parks, T. D., Howard, E. D., Wolpert, T. J., Arp, D. J., and Dougherty, W. G. (1995) Virology 210, 194-201
26. Gefflaut, T., Blonski, C., Perie, J., and Willson, M. (1995) Prog. Biophys. Mol. Biol. 63, 301-340
27. Banki, K., and Perl, A. (1996) FEBS Lett. 378, 161-165
28. Jager, S. A., Shapovalova, I. V., Jekel, P. A., Alkema, W. B., Svedas, V. K., and Janssen, D. B. (2008) J. Biotechnol. 133, 18-26
29. Amiss, T. J., Sherman, D. B., Nycz, C. M., Andaluz, S. A., and Pitner, J. B. (2007) Protein Sci. 16, 2350-2359
30. Ang, E. L., Obbard, J. P., and Zhao, H. (2007) FEBS J. 274, 928-939
31. Fujii, K., Minagawa, H., Terada, Y., Takaha, T., Kuriki, T., Shimada, J., and Kaneko, H. (2005) Appl. Environ. Microbiol. 71, 5823-5827
32. Parikh, M. R., and Matsumura, I. (2005) J. Mol. Biol. 352, 621-628
33. Williams, G. J., Woodhall, T., Nelson, A., and Berry, A. (2005) Protein Eng. Des. Sel. 18, 239-246
34. Georgescu, R., Bandara, G., and Sun, L. (2003) Directed Evolution Library Creation: Methods and Protocols, Humana Press Inc., Totowa, NJ
35. Schürmann, M., Schürmann, M., and Sprenger, G. (2002) J. Mol. Catal. B Enzym. 19-20, 247-252
36. Briggs, G. E., and Haldane, J. B. (1925) Biochem. J. 19, 338-339
37. Kohler, U., Cerff, R., and Brinkmann, H. (1996) Plant Mol. Biol. 30, 213-218
38. Remm, M., Storm, C. E., and Sonnhammer, E. L. (2001) J. Mol. Biol. 314, 1041-1052
39. Valayannopoulos, V., Verhoeven, N. M., Mention, K., Salomons, G. S., Sommelet, D., Gonzales, M., Touati, G., de Lonlay, P., Jakobs, C., and Saudubray, J. M. (2006) J. Pediatr. 149, 713-717
40. Verhoeven, N. M., Huck, J. H., Roos, B., Struys, E. A., Salomons, G. S., Douwes, A. C., van der Knaap, M. S., and Jakobs, C. (2001) Am. J. Hum. Genet. 68, 1086-1092
41. Verhoeven, N. M., Wallot, M., Huck, J. H., Dirsch, O., Ballauf, A., Neudorf, U., Salomons, G. S., van der Knaap, M. S., Voit, T., and Jakobs, C. (2005) J. Inherit. Metab. Dis. 28, 169-179
42. Grossman, C. E., Niland, B., Stancato, C., Verhoeven, N. M., Van Der Knaap, M. S., Jakobs, C., Brown, L. M., Vajda, S., Banki, K., and Perl, A. (2004) Biochem. J. 382, 725-731
43. Perl, A., Qian, Y., Chohan, K. R., Shirley, C. R., Amidon, W., Banerjee, S., Middleton, F. A., Conkrite, K. L., Barcza, M., Gonchoroff, N., Suarez, S. S., and Banki, K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 14813-14818
44. Banki, K., Colombo, E., Sia, F., Halladay, D., Mattson, D. H., Tatum, A. H., Massa, P. T., Phillips, P. E., and Perl, A. (1994) J. Exp. Med. 180, 1649-1663
45. Esposito, M., Venkatesh, V., Otvos, L., Weng, Z., Vajda, S., Banki, K., and Perl, A. (1999) J. Immunol. 163, 4027-4032
46. Schmidt, S. (1999) Mult. Scler. 5, 147-160