Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Osteoarthritis and Cartilage

Volumn 17, Issue 1, 2009, Pages 124-131

  Jones, S W ^a   Brockbank, S M V ^a   Clements, K M ^a   Le Good, N ^a   Campbell, D ^a   Read, S J ^a   Needham, M R C ^a   Newham, P ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Cartilage; MAPKAPK2; Metalloproteinases; MK2; PGE2

Indexed keywords

COLLAGENASE 3; HEAT SHOCK PROTEIN 27; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; SMALL INTERFERING RNA; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTHRALGIA; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL ISOLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOLOGY; JOINT DESTRUCTION; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

ADENOVIRIDAE; AGED; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; ENZYME ACTIVATION; GENETIC VECTORS; HUMANS; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 57549091806     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.05.001     Document Type: Article

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