Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on fas antigen-antibody reaction in collagen-induced arthritis monkeys

Life Sciences

Volumn 80, Issue 22, 2007, Pages 2005-2014

  Saito, Motoko ^a   Yoshigae, Yasushi ^a   Nakayama, Junichi ^a   Ogawa, Yukie ^a   Ohtsuki, Masahiko ^b   Kurihara, Atsushi ^a   Ikeda, Toshihiko ^a  

^a DAIICHI SANKYO CO   (Japan)

^b DAIICHI SANKYO INC   (United States)

Author keywords

Anti Fas monoclonal antibody; Collagen induced arthritis; Monkey; Pharmacokinetics; Tissue distribution

Indexed keywords

COLLAGEN TYPE 2; FAS ANTIBODY; FAS ANTIGEN; IODINE 125; MONOCLONAL ANTIBODY; R 125224; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARM; ARTHRITIS; ARTICLE; AXILLARY LYMPH NODE; BONE MARROW; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; JOINT; JOINT CAVITY; LIVER; LIVER CELL; LUNG; LYMPHOCYTE; MESENTERY LYMPH NODE; MONKEY; NONHUMAN; OVARY; PLASMA; RADIATION DETECTION; RADIOACTIVITY; SPLEEN; THYMUS; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BONE MARROW; CROSS REACTIONS; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; HAPLORHINI; HUMANS; IODINE RADIOISOTOPES; JOINTS; LIVER; LUNG; LYMPH NODES; MACACA FASCICULARIS; MICE; RADIOIMMUNODETECTION; SPLEEN; TISSUE DISTRIBUTION;

MACACA FASCICULARIS;

EID: 34247641661     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.02.043     Document Type: Article

References (21)

1. Courtenay J.S., Dallman M.J., Dayan A.D., Martin A., and Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283 (1980) 666-668
2. Haruyama H., Ito S., Miyadai K., Takahashi T., Kawaida R., Takayama T., Hanzawa H., Hata T., Yamaguchi J., Yoshida-Kato H., Ichikawa K., Ohsumi J., Yonehara S., and Serizawa N. Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab Fragment. Biological Pharmaceutical Bulletin 25 (2002) 1537-1545
3. Ichikawa K., Yoshida-Kato H., Ohtsuki M., Ohsumi J., Yamaguchi J., Takahashi S., Tani Y., Watanabe M., Shiraishi A., Nishioka K., Yonehara S., and Serizawa N. A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity. International Immunology 12 (2000) 555-562
4. Inazawa Y., and Yonehara S. Fas-induced in vivo apoptosis in bone marrow anti-Fas mAb-induced elimination and successive proliferation of Fas-expressing cells especially those of myeloid lineage. Cell Structure and Function 24 (1999) 151-159
5. Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S., Sameshima M., Hase A., Seto Y., and Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66 (1991) 233-243
6. Kuwahara H., Tani Y., Ogawa Y., Takaichi Y., Shiraishi A., and Ohtsuki M. Therapeutic effect of novel anti-human Fas antibody HFE7A on graft-versus-host disease model. Clinical Immunology 99 (2001) 340-346
7. Leithäuser F., Dhein J., Mechtersheimer G., Koretz K., Brüderlein S., Henne C., Schmidt A., Debatin K.M., Krammer P.H., and Möller P. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Laboratory Investigation 69 (1993) 415-429
8. Mastuno H., Yudoh K., Nakazawa F., Sawai T., Uzuki M., Nishioka K., Yonehara S., Nakayama J., Ohtsuki M., and Kimura T. Antirheumatic effects of humanized anti-Fas monoclonal antibody in human rheumatoid arthritis/SCID mouse chimera. Journal of Rheumatology 29 (2002) 1609-1614
9. Matsuno H., Sawai T., Nezuka T., Uzuki M., Tsuji H., Nishimoto N., and Yoshizaki K. Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody: use of rheumatoid arthritis tissue implants in the SCID mouse model. Arthritis Rheumatism 41 (1998) 2014-2021
10. McKenzie S.E., Taylor S.M., Malladi P., Yuhan H., Cassel D.L., Chien P., Schwartz E., Schreiber A.D., Surrey S., and Reilly M.P. The role of the human Fc receptor FcγRIIA in the immune clearance of platelets: a transgenic mouse model. Journal of Immunology 162 (1999) 4311-4318
11. Murayama Y., Terao K., and Inoue-Murayama M. Molecular cloning and characterization of cynomolgus monkeys Fas. Human Immunology 61 (2000) 474-485
12. Nakayama J., Ogawa Y., Yoshigae Y., Onozawa Y., Yonemura A., Saito M., Ichikawa K., Yamoto T., Komai T., Tatsuta T., and Ohtsuki M. A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells. International Immunology 18 (2006) 113-124
13. Ogasawara J., Watanabe-Fukunaga R., Adachi M., Matsuzawa A., Kasugai T., Kitamura Y., Itoh N., Suda T., and Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 364 (1993) 806-809
14. Ogawa Y., Ohtsuki M., Uzuki M., Sawai T., Onozawa Y., Nakayama J., Yonemura A., Kimura T., and Matsuno H. Suppression of osteoclastogenesis in rheumatoid arthritis by induction of apoptosis in activated CD4+T cells. Arthritis Rheumatism 48 (2003) 3350-3358
15. Saito M., Yoshigae Y., Nakayama J., Ogawa Y., Ohtsuki M., Kurihara A., and Ikeda T. In SCID mice with transplanted joint tissues from rheumatism patients, a model mice of human rheumatoid arthritis, anti-human Fas antibody (R-125224) distributes specifically to human synovium. Pharmaceutical Research 24 2 (2007) 310-317
16. Sakai K., Matsuno H., Morita I., Nezuka T., Tsuji H., Shirai T., Yonehara S., Hasunuma T., and Nishioka K. Potential withdrawal of rheumatoid synovium by the induction of apoptosis using a novel in vivo model of rheumatoid arthritis. Arthritis Rheumatism 41 (1998) 1251-1257
17. Stuart J.M., Townes A.S., and Kang A.H. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. Journal of Clinical Investigation 69 (1982) 673-683
18. Takahashi T., Tanaka M., Brannan C.I., Jenkins N.A., Copeland N.G., Suda T., and Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 (1994) 969-976
19. Trentham D.E., Townes A.S., and Kang A.H. Autoimmunity to type II collagen an experimental model of arthritis. Journal of Experimental Medicine 46 (1977) 857-868
20. Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., and Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356 (1992) 314-317
21. Yu Q., Liu X., and Shi G. Immunohistochemical study of Fas antigen expression in synovial tissues from patients with rheumatoid arthritis. Chinese Medical Journal 111 (1998) 211-213