Ras triggers acidosis-induced activation of the extracellular-signal- regulated kinase pathway in cardiac myocytes

Biochemical Journal

Volumn 399, Issue 3, 2006, Pages 493-501

  Haworth, Robert S ^a   Dashnyam, Semjidmaa ^a   Avkiran, Metin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acidosis; Cardiac myocyte; Extracellular signal regulated kinase (ERK) pathway; G protein coupled receptor (GPCR); Protein kinase C (PKC); Raf; Ras

Indexed keywords

CHEMICAL ACTIVATION; ENZYME INHIBITION; ENZYMES; GENETIC ENGINEERING; PH EFFECTS; SIGNAL PROCESSING;

ACIDOSIS; CARDIAC MYOCYTES; EXTRACELLULAR-SIGNAL-REGULATED KINASE (ERK) PATHWAYS; G-PROTEIN-COUPLED RECEPTOR (GPCR); PROTEIN KINASE C (PKC);

CELLS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMMONIUM CHLORIDE; BICARBONATE; CARIPORIDE; FARNESYL PROTEIN TRANSFERASE INHIBITOR III; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ACIDOSIS; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; NONHUMAN; PH; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ACIDOSIS; AMMONIUM CHLORIDE; ANIMALS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; ENZYME ACTIVATION; GUANIDINES; HYDROGEN-ION CONCENTRATION; ISOTONIC SOLUTIONS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; PHOSPHONIC ACIDS; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RECOMBINANT FUSION PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 33750566657     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051628     Document Type: Article

References (36)

1. Orchard, C. H. and Kentish, J. C. (1990) Effects of changes of pH on the contractile function of cardiac muscle. Am. J. Physiol. 258, C967-C9 81
2. + exchanger. Mol. Cell. Biochem. 125, 137-143
3. Leem, C. H., Lagadic-Gossman, D. and Vaughan-Jones, R. D. (1999) Characterisation of intracellular pH regulation in the guinea-pig ventricular myocyte. J. Physiol, 517, 159-180
4. + exchanger isoform 1 (NHE-1). J. Biol. Chem, 269, 5583-5588
5. + exchanger NHE1 through sequence-specific interaction. Biochemistry 36, 12854-12861
6. + exchanger NHE1 by sustained intracellular acidosis. J. Biol. Chem. 278, 31676-31684
7. 1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors. Cell. Signalling 17, 655-664
8. RSK activity in vitro and in adult ventricular myocytes. Br. J. Pharmacol. 145, 477-489
9. + exchanger: evidence for a receptor-mediated mechanism involving protein kinase C. Circ. Res. 79, 705-715
10. + exchanger during postnatal development in the rat: changes in mRNA expression and sarcolemmal activity. J. Mol. Cell. Cardiol. 29, 321-332
11. + exchanger activity by angiotensin II in adult rat ventricular myocytes. Circ. Res. 85, 919-930
12. + exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes. Br. J. Pharmacol. 134, 1587-1595
13. Sturgill, T. W., Ray, L. B., Erikson, E. and Maller, J. L. (1988) Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 334, 715-718
14. Braz, J. C., Bueno, O. F., de Windt, L. J. and Molkentin, J. D. (2002) PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase 1/2 (ERK1/2). J. Cell Biol. 156, 905-916
15. Lackey, K., Cory, M., Davis, R., Frye, S. V., Harris, R. A., Hunter, R. N., Jung, D. K., McDonald, O. B., McNutt, R. W., Peel, M. R. et al. (2000) The discovery of potent cRaf1 kinase inhibitors. Bioorg. Med. Chem. Lett. 10, 223-226
16. Hall-Jackson, C. A., Eyers, P A., Cohen, P., Goedert, M., Boyle, F. T., Hewitt, N., Plant, H. and Hedge, P. (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem. Biol. 6, 559-568
17. Thorburn, J., McMahon, M. and Thorburn, A. (1994) Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J. Biol. Chem. 269, 30580-30586
18. Xu, Y. and Casey, G. (1996) Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics 35, 397-402
19. Ishii, S., Kihara, Y. and Shimizu, T. (2005) Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J. Biol. Chem. 280, 9083-9087
20. Ludwig, M. G., Vanek, M., Guerini, D., Gasser, J. A., Jones, C. E., Junker, U., Hofstetter, H., Wolf, R. M. and Seuwen, K. (2003) Proton-sensing G-protein-coupled receptors. Nature 425, 93-98
21. Wang, J. Q., Kon, J., Mogi, C., Tobo, M., Damirin, A., Sato, K., Komachi, M., Malchinkhuu, E., Murata, N., Kimura, T. et al. (2004) TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J. Biol. Chem. 279, 45626-45633
22. Chiloeches, A., Paterson, H. F., Marais, R., Clerk, A., Marshall, C. J. and Sugden, P. H. (1999) Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. J. Biol. Chem. 274, 19762-19770
23. Zou, Y., Komuro, I., Yamazaki, T., Aikawa, R., Kudoh, S., Shiojima, I., Hiroi, Y., Mizuno, T. and Yazaki, Y. (1996) Protein kinase C, but not tyrosine kinases or ras, plays a critical role in angiotensin II-induced activation of raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J. Biol. Chem. 271, 33592-33597
24. 2+/calmodulin- dependent protein kinase II to cell membranes during complete cerebral ischemia. Brain Res. 849, 119-127
25. Marais, R., Light, Y., Paterson, H. F. and Marshall, C. J. (1995) Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14, 3136-3145
26. Mundina-Weilenmann, C., Vittone, L., Cingolani, H. E. and Orchard, C. H. (1996) Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle. Am J. Physiol. 270, C107-C114
27. 17 of phospholamban in rat cardiac muscle. Pflugers Arch. 434, 475-483
28. Zheng, M., Reynolds, C., Jo, S. H., Wersto, R., Han, Q. and Xiao, R. P. (2005) Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury. FASEB J. 19, 109-111
29. Tsuganezawa, H., Sato, S., Yamaji, Y., Preisig, P. A., Moe, O. W. and Alpern, R. J. (2002) Role of c-src and ERK in acid-induced activation of NHE3. Kidney Int. 62, 41-50
30. + exchange in colonocytes mediated by the zinc-sensing receptor. J. Biol. Chem. 279, 51804-51816
31. Heo, J., Gao, G. and Campbell, S. L. (2004) pH-dependent perturbation of ras-guanine nucleotide interactions and ras guanine nucleotide exchange. Biochemistry 43, 10102-10111
32. Feig, L. A. and Cooper, G. M. (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Biol. Cell 8, 3235-3243
33. Schweighoffer, F., Cai, H., Chevalier-Multon, M. C., Fath, I., Cooper, G. M. and Tocque, B. (1993) The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17. Mol. Biol. Cell 13, 39-43
34. Crespo, P., Xu, N., Simonds, W. F. and Gutkind, J. S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369, 418-420
35. Bogoyevitch, M. A., Marshall, C. J. and Sugden, P. H. (1995) Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J. Biol. Chem. 270, 26303-26310
36. Silberbach, M., Gorenc, T., Hershberger, R. E., Stork, P. J. S., Steyger, P. S. and Roberts, C. T. (1999) Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes. J. Biol. Chem. 274, 24858-24864