The bisindolylmaleimide protein kinase C inhibitor, Ro 32-2241, reverses multidrug resistance in KB tumour cells

Cancer Chemotherapy and Pharmacology

Volumn 43, Issue 5, 1999, Pages 371-378

  Merritt, Janet E ^a   Sullivan, John A ^a   Drew, Lisa ^b   Khan, Abida ^a   Wilson, Kevin ^a   Mulqueen, Michael ^a   Harris, William ^a   Bradshaw, David ^a   Hill, Christopher H ^a   Rumsby, Martin ^b   Warr, Roger ^b  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Bisindolylmaleimides; Multidrug resistance; P glycoprotein; Protein kinase C inhibitors; Reversal

Indexed keywords

3 [8,1 AMINO 2 METHYLPROPYL) 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 3 INDOLYL) 1H PYRROLE 2,5 DIONE; BISINDOLYLMALEIMIDE; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; PACLITAXEL; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

AZIDES; BINDING SITES; CELL SURVIVAL; DAUNORUBICIN; DIHYDROPYRIDINES; DNA, NEOPLASM; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; HUMANS; INDOLES; KB CELLS; MALEIMIDES; P-GLYCOPROTEIN; PROTEIN KINASE C; TUMOR CELLS, CULTURED;

EID: 0033062920     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050909     Document Type: Article

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