Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic rats

Malaysian Journal of Medical Sciences

Volumn 14, Issue 2, 2007, Pages 47-53

  Budin, Siti Balkis ^a   Kee, Kwa Poi ^a   Eng, Monica Yau Swee ^a   Osman, Khairul ^a   Bakar, Mokhtar Abu ^b   Mohamed, Jamaludin ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Alpha lipoic acid; Diabetes mellitus; Dyslipidemia; Hyperglycemia; Islet cells

Indexed keywords

CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; THIOCTIC ACID; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; DRUG MECHANISM; DYSLIPIDEMIA; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 57349097759     PISSN: 1394195X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Mohamad S, Taha A, Bamezai, RNK, Basir S, Baquer NZ. Lower dose of vanadate in combination with trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan-diabetic rats. Clinica Chimica Acta. 2004; 342: 105-114.
2. Ihara Y, Toyokumi S, Uchida K, Odaka H, Tanaka T, Ikeda H. Hyperglycemia causes oxidative stress in pancreatic beta cells of GK rats a model of type 2 diabetes. Diabetes. 1999; 48: 927-932.
3. Koo JR, Ni Z, Oviesi F, Vaziri ND. Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats. Clinical Experimental Hypertension. 2002; 24: 333-344.
4. Ravi K, Rajasekaran S, Subramanium S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food and Chemical Toxicology. 2005; 43: 1433-1439.
5. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant a-lipoic acid. Free Radical Biology & Medicine. 1997; 22: 359-378.
6. Packer L., Kreamer K. and Rimbach G. Molecular aspect of lipoic acid in the prevention of diabetes complications. Nutrition. 2001; 17: 888-895.
7. Eross J, Kreutzmann D, Jimenez M, Keen R, Roger S, Cowell C, Vines R, Silink M. Colometric measurement of glycosylated protein in whole blood, red blood cells, plasma and dried blood. Annal Clinical Biochemistry. 1984; 21: 477-483.
8. Friedewald WT, Levy RI, Fredicson DS.. Estimation of the concentration of low density lipoprotein in plasma without use of preparative ultracentrifuge. Clinical Chemistry 1972; 28: 499-502.
9. Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Futani Y, Umayahara Y. Beneficial effects of antioxidant in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes. 1999; 48: 2398-2406.
10. Bynes JW, Thorpe SR, The role of oxidative stress in diabetic complications. Current Opinion in Endocrinology. 1996; 3: 277-284
11. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavanoid antioxidant, prevents and protects streptozotocin-induces oxidative stress and -cells damage in rats pancreas. Pharmacological Research. 2005; 51: 117-123.
12. Kocak, G., Aftan, F., Elberg, S., Yildizoglu,-Ari, N. & Karasu, C. 2000. Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vassel alredy damaged by streptozotocin -diabetic rats. Diabetes Nutrition and Metabolism. 13: 308-318.
13. Szkudelski T, The mechanism of alloxan and streptozotocin action in cells of the rat pancreas. Physiology Research. 2001; 50: 537-546.
14. Vessal M, Hemmati M, Vasie M. Antidiabetic effects of quercetinin in streptozotocin-induced diabetic rats. Comparative Biochemistry and Physiology Toxicology & Pharmacology. 2003; 93: 189-200.
15. Thirunavukkarasu, V., Anita Nandhini, A.T. & Arunadha, C.Y. 2004. Effects of alpha lipoic acids on lipid profile in rats fed a high-fructose diet. Experimental Diabetisity Research 5(3): 195-200.
16. Lopes-Virella MF, Whitmann HJ, Mayfield PK, Loadhott CB, Colwell JA. Effects of metabolic control on lipid, lipoprotein and apolipoprotein levels in 55 insulin-dependent diabetic patients: a longitudinal study. Diabetes. 1983; 32: 20-25.
17. Kondo A, Muranaka Y, Ohta I, Notsu K, Manabe M, Kotani K, saito K, Mackawa M, Kanno T. Relationship between triglycerides concentrations and LDL sized evaluated by malondialdehyde-modified LDL. Clinical Chemistry. 2001; 47: 893-900.