Formulation strategies to minimize oxidative damage in lyophilized lipid/DNA complexes during storage

Journal of Pharmaceutical Sciences

Volumn 97, Issue 12, 2008, Pages 5089-5105

  Molina, Marion D C ^a   Anchordoquy, Thomas J ^b  

^a Nucleonics Inc   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Chelating agents; Gene delivery; Lyophilization; Metal contamination; Nonviral vectors; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CHELATING AGENT; FLUORESCAMINE; LIPID HYDROPEROXIDE; LIPOPLEX; METAL; METHIONINE; PENTETIC ACID; REACTIVE OXYGEN METABOLITE; REAGENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TREHALOSE;

ANIMAL CELL; ARTICLE; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; LIPID PEROXIDATION; MOISTURE; NONHUMAN; OXIDATIVE STRESS; PHYSICAL CHEMISTRY;

EID: 57349087176     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21365     Document Type: Article

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