Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells

Journal of Bone and Mineral Research

Volumn 17, Issue 10, 2002, Pages 1774-1784

  Windischhofer, W ^a   Zach, D ^a   Fauler, G ^a   Raspotnig, G ^a   Kfeler H ^a   Leis, H J ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

Endothelin 1; MAPK; MC3T3 E1; Osteoblast; Prostaglandin endoperoxide G H synthase 2

Indexed keywords

BOTULINUM TOXIN; CHOLERA TOXIN; CYCLOOXYGENASE 2; ENDOTHELIN 1; ENZYME INHIBITOR; EXOENZYME C3, CLOSTRIDIUM BOTULINUM; ISOENZYME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALPHOSTIN C; CHELERYTHRINE; COMPLEMENTARY DNA; ENDOTHELIN RECEPTOR; FORSKOLIN; GENE PRODUCT; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HERBIMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROPRANOLOL; PROTEIN KINASE C; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; OSTEOBLAST; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; ANIMAL CELL; BONE METABOLISM; BONE REMODELING; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; NONHUMAN; NORTHERN BLOTTING; PROTEIN PHOSPHORYLATION;

ADP RIBOSE TRANSFERASES; ANIMALS; BOTULINUM TOXINS; CELL LINE; CHOLERA TOXIN; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTHELIN-1; ENZYME INDUCTION; ENZYME INHIBITORS; ISOENZYMES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 0036786943     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.10.1774     Document Type: Article

References (67)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T 1988 A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415.
2. Inoue A, Yanigasawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Maskai T 1989 The human endothelin family-3 structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci USA 86:2863-2867.
3. Bloch KD, Eddy RL, Shows TB, Quertermous T 1989 cDNA cloning and chromosomal assignment of the gene encoding endothelin 3. J Biol Chem 264:18156-18161.
4. Ohlstein EH, Elliott JD, Feuerstein GZ, Ruffolo RR Jr 1996 Endothelin receptors: Receptor classification, novel receptor antagonists, and potential therapeutic agents. Med Res Rev 16:365-390.
5. Masaki T, Ninomiya H, Sakamoto A, Okamoto Y 1999 Structural basis of the function of endothelin receptor. Mol Cell Biochem 190:153-156.
6. Sokolovsky M 1995 Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades. Cell Mol Neurobiol 15:561-571.
7. Haynes WG, Webb DJ 1993 The endothelin family of peptides: Local hormones with diverse roles in health and disease? Clin Sci 84:485-500.
8. Sokolovsky M 1995 Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol Ther 68:435-471.
9. Douglas SA, Ohlstein EH 1997 Signal transduction mechanisms mediating the vascular actions of endothelin. J Vasc Res 34:152-164.
10. Battistini B, Chailler P, D'Orleans-Juste P, Brìre N, Sirois P 1993 Growth regulatory properties of endothelins. Peptides 14:385-399.
11. Daub H, Weiss FU, Wallasch C, Ullrich A 1996 Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-560.
12. Stern PH, Tatrai A, Semler DE, Lee SK, Lakatos P, Strieleman PJ, Tarjan G, Sanders JL 1995 Endothelin receptors, second messengers, and actions in bone. J Nutr 125:2028S-2032S.
13. Semler D, Ohlstein EH, Nambi P, Slater C, Stern PH 1995 Endothelin-1 evoked calcium transients in UMR-106 osteoblastic osteosarcoma cells are mediated through ETA and ETB receptors. J Pharmacol Exp Ther 272:1052-1058.
14. B receptor mRNA is down-regulated by endothelins through decreasing the intracellular stability of mRNA molecules. Biochem Biophys Res Commun 186:342-347.
15. A receptor mediates the signaling of endothelin-I in osteoblast-like cells. Bone 21:143-146.
16. B̈rcs̈k I, Schairer HU, Sommer U, Wakley GK, Schneider U, Geiger F, Niethard FU, Ziegler R, Kasperk CH 1998 Glucocorticoids regulate the expression of the human osteoblastic endothelin A receptor gene. J Exp Med 188:1563-1573.
17. Tatrai A, Foster S, Lakatos P, Shankar G, Stern PH 1992 Endothelin-1 actions on resorption, collagen and non-collagen protein synthesis, and phosphatidylinositol turnover in bone organ cultures. Endocrinology 131:603-607.
18. Takuwa Y, Masaki T, Yamashita K 1990 The effects of the endothelin family peptides on cultured osteoblastic cells from rat calvariae. Biochem Biophys Res Commun 170:998-1005.
19. Alam ASMT, Gallagher A, Shankar V, Ghatei MA, Datta HK, Huang CLH, Moonga BS, Chambers TJ, Bloom SR, Zaidi M 1992 Endothelin-1 inhibits osteoclastic bone resorption by a direct effect on cell motility: Implications for the vascular control of bone resorption. Endocrinology 130:3617-3624.
20. 2+ from extra- and intracellular pools in osteoblastic cells. Am J Physiol 257:E797-E803.
21. Zach D, Windischhofer W, Leis HJ 2001 Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B. Bone 28:595-602.
22. Hiruma Y, Inoue A, Shiohama A, Otsuka E, Hirose S, Yamaguchi A, Hagiwara H 1998 Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor. Am J Physiol 275:R1099-R1105.
23. Schvartz I, Ittoop O, Davidai G, Hazum E 1992 Endothelin rapidly stimulates tyrosine phosphorylation in osteoblast-like cells. Peptides 13:159-163.
24. Perkins SL, Sarraj E, Kling SJ, Kohan DE 1997 Endothelin stimulates osteoblastic production of IL-6 but not macrophage colony-stimulating factor. Am J Physiol 272:E461-E468.
25. Kawamura H, Otsuka T, Tokuda H, Matsuno H, Niwa M, Matsui N, Uematsu T, Kozawa O 1999 Involvement of p42/44 MAP kinase in endothelin-1-induced interleukin-6 synthesis in osteoblast-like cells. Bone 24:315-320.
26. Kawamura H, Otsuka T, Matsuno H, Niwa M, Matsui N, Kato K, Uematsu T, Kozawa O 1999 Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: Involvement of p38 MAP kinase. Am J Physiol 277:E1046-E1054.
27. Suzuki A, Oiso Y, Kozawa O 1994 Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells. Mol Cell Endocrinol 105:193-196.
28. Kozawa O, Suzuki A, Shinoda J, Ozaki N, Oiso Y, Uematsu T 1997 Involvement of phospholipase D activation in endothelin-1 induced release of arachidonic acid in osteoblast-like cells. J Cell Biochem 64:376-381.
29. Leis HJ, Zach D, Huber E, Windischhofer W 1998 Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): Evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C. Endocrinology 139:1268-1277.
30. Voelkel EF, Tashjian AH, Levine L 1980 Cyclooxygenase products of arachidonic acid metabolism by mouse bone in organ culture. Biochim Biophys Acta 620:418-428.
31. Klein DC, Raisz LG 1970 Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology 86:1436-1440.
32. 2 on bone formation in cultured fetal rat calvariae: Interaction with cortisol. Endocrinology 126:1654-1659.
33. Leis HJ, Hulla W, Gruber R, Huber E, Zach D, Gleispach H, Windischhofer W 1997 Phenotypic heterogeneity of osteoblast-like MC3T3-E1 cells: Changes of bradykinin-induced prostaglandin E2 production during osteoblast maturation. J Bone Miner Res 12:541-551.
34. Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O, Alander CB, Raisz LG 1993 Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J Biol Chem 268:25643-25649.
35. Ren XD, Kiosses WB, Schwartz MA 1999 Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18:578-585.
36. Narumiya S, Sekine A, Fujiwara M 1988 Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product. J Biol Chem 263:17255-17257.
37. Aktories K, Braun U, Rosener S, Just I, Hall A 1989 The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem Biophys Res Commun 158:209-213.
38. Wang P, Bitar KN 1998 RhoA regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. Am J Physiol 275: G1454-G1462.
39. Shraga-Levine Z, Sokolovsky M 2000 Functional coupling of G proteins to endothelin receptors is ligand and receptor sub-type specific. Cell Mol Neurobiol 20:305-317.
40. Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR 1991 TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266: 12866-12872.
41. Pavalko FM, Chen NX, Turner CH, Burr DB, Atkinson S, Hsieh YF, Qiu J, Duncan RL 1998 Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. Am J Physiol 275:C1591-C1601.
42. 2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts. Am J Physiol 278:C989-C997.
43. Pilbeam CC, Harrison JR, Raisz LG 1996 Prostaglandins and bone metabolism. In: Bilezikian-JP, Raisz-LG, Rodan-GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 715-728.
44. Tetradis S, Pilbeam CC, Liu Y, Kream BE 1996 Parathyroid hormone induces prostaglandin G/H synthase-2 expression by a cyclic adenosine 3[prime], 5 [prime]-monophosphate-mediated pathway in the murine osteoblastic cell line MC3T3-E1. Endocrinology 137:5435-5440.
45. Sciorra VA, Daniel LW 1996 Phospholipase D-derived products in the regulation of 12-O-tetradecanoylphorbol-13-acetate-stimulated prostaglandin synthesis in Madin-Dardy Canine Kidney cells. J Biol Chem 271:14226-14232.
46. 2A receptors. J Cell Physiol 175:341-347.
47. Imamura T, Ishibashi K, Dalle S, Ugi S, Olefsky JM 1999 Endothelin-1-induced GLUT4 translocation is mediated via Ga(q/11 protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem 274:33691-33695.
48. Barry OP, Kazanietz MG, Pratico D, FitzGerald GA 1999 Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. J Biol Chem 274:7545-7556.
49. McGinty A, Foschi M, Chang YWE, Han J, Dunn MJ, Sorokin-A 2000 Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. Biochem J 352:419-424.
50. 2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem 273:28670-28676.
51. LaPointe MC, Isenovic E 1999 Interleukin-1 '62 regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. Hypertension 33:276-282.
52. Guan Z, Buckman SY, Pentland AP, Templeton DJ, Morrison AR 1998 Induction of cyclooxygenase-2 by the activated MEKK1 → SEK1/MKK4 → p38 mitogen-activated protein kinase pathway. J Biol Chem 273:12901-12908.
53. Xie W, Herschman HR 1995 v-src Induces prostaglandin synthase 2gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J Biol Chem 270:27622-27628.
54. Reiser COA, Lanz T, Hofman F, Hofer G, Rupprecht HD, Goppelt-Struebe M 1998 Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and egr-1: A critical role for the mitogen-activated protein kinase p38 and for Rho proteins. Biochem J 330:1107-1114.
55. Ridley AJ, Hall A 1994 Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase. EMBO J 13:2600-2610.
56. FAK and paxillin in permeabilized Swiss 3T3 cells. J Biol Chem 270:6984-6990.
57. α13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 270:24631-24634.
58. αq induce Rho-dependent neurite retraction through different signaling pathways. J Biol Chem 273:28700-28707.
59. Maulon L, Mari B, Bertolotto C, Ricci JE, Luciano F, Belhacene N, Deckert M, Baier G, Auberger P 2001 Differential requirements for ERK1/2 and p38 MAPK activation by thrombin in T cells. Oncogene 20:1964-1972.
60. Mao J, Yuan H, Xie W, Simon MI, Wu D 1998 Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem 273:27118-27123.
61. '6113 in receptor-mediated stress fiber formation. J Biol Chem 274:17901-17907.
62. Wang D, Christensen K, Chawla K, Xiao G, Krebsbach PH, Franceschi RT 1999 Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res 14:893-903.
63. Malcolm KC, Elliott CM, Exton JH 1996 Evidence for Rhomediated agonist stimulation of phospholipase D in Rat1 fibriblasts. J Biol Chem 271:13135-13139.
64. 2′61-induced phospholipase D activation in the osteoblast-like cell line MC3T3-E1. Prostaglandins 54:475-492.
65. Sorokin A, Kozlowski P, Graves L, Philip A 2001 Protein tyrosine kinase Pyk2 mediates endothelin-induced p38 MAP kinase activation in glomerular mesangial cells. J Biol Chem 276:21521-21528.
66. Marinissen MJ, Chiariello M, Gutkind JS 2001 Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 '67 MAP kinase pathway. Genes Dev 15:535-553.
67. Seasholtz TM, Majumdar M, Brown JH 1999 Rho as a mediator of G protein-coupled receptor signaling. Mol Pharmacol 55:949-956.