Role of the kidney in iron homeostasis: Renal expression of Prohepcidin, Ferroportin, and DMT1 in anemic mice

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 4, 2008, Pages

  Veuthey, Tania ^a   D'Anna, María Cecilia ^a   Roque, Marta Elena ^a  

^a UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

Author keywords

Anemia; Divalent metal transporter 1

Indexed keywords

FERROPORTIN; HEPCIDIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROHEPCIDIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ERYTHROPOIESIS; FEMALE; HEMOLYTIC ANEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IRON BALANCE; IRON METABOLISM; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STAINING;

EID: 57049185266     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90216.2008     Document Type: Article

References (34)

1. Abboud S, Haile D. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-19912, 2000.
2. Anderson GJ, Frazer DM, Wilkins SJ, Becker EM, Millard KN, Murphy TL, McKie AT, Vulpe CD. Relationship between intestinal iron transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans 30: 724-726, 2002.
3. Brown D, Hirsch S, Gluck S. Localization of a Proton-Pumping ATPase in rat kidney. J Clin Invest 82: 2114-2126, 1988.
4. Canonne-Hergaux F, Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mice. Kidney Int 62: 147-156, 2002.
5. Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93: 4406-4417, 1999.
6. Criswell KA, Sulkanen AP, Hochbaum AF, Bleavins MR. Effects of phenylhydrazine or phlebotomy on peripheral blood, bone marrow and erythropoietin in Wistar rats. J Appl Toxicol 20: 25-34, 2000.
7. Dallalio G, Law E, Means RT. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations. Blood 107: 2702-2704, 2006.
8. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish Ferroportin 1 identifies a conserved vertebrate iron exporter. Nature 403: 778-781, 2000.
9. Dworkin LD, Brenner BM. The kidney. In: The Renal Circulations, edited by Brenner BM. Philadelphia: Saunders, 1996.
10. Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, Riccardi D. Cellular localization of divalent metal transporter 1 in rat kidney. Am J Physiol Renal Physiol 280: F803-F814, 2001.
11. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002.
12. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta 1763: 690-699, 2006.
13. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997.
14. Hara H, Ogawa M. Erythropoietic precursors in mice with phenylhydrazine-induced anemia. Am J Hematol 1: 453-458, 1976.
15. Koeppen BM, Steinmetz PR. Basic mechanisms of urinary acidification. Med Clin North Am 67: 753-770, 1983.
16. Kulaksiz H, Theilig F, Bachmann S, Gehrke SG, Rost D, Janetzko A, Cetin Y, Stremmel W. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol 184: 361-370, 2005.
17. Lacombe C, DaSilva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, Bariety J, Varet B, Tambourin P. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 81: 620-623, 1988.
18. Latunde-Dada GO, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Tissue-specific changes in iron metabolism genes in mice following phenylhidrazine-induced hemolysis. Biochim Biophys Acta 1690: 169-176, 2004.
19. Malyszko J, Mysliwiec M. Hepcidin in anemia and inflammation in chronic kidney disease. Kidney Blood Press Res 30: 15-30, 2007.
20. McKie AT, Barlow DJ. The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Eur J Physiol 447: 801-806, 2004.
21. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. A novel duodenal iron-regulated transporter IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5: 299-309, 2000.
22. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, McVey Ward D, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to Ferroportin and inducing its internalization. Science 306: 2090-2093, 2004.
23. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98: 8780-8785, 2001.
24. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation. J Clin Invest 110: 1037-1044, 2002.
25. Nicolas G, Viatte L, Bennoun M, Beaumont C, Kahn A, Vaulont S. Hepcidin: a new iron regulatory peptide. Blood Cells Mol Dis 29: 327-335, 2002.
26. Oates PS, Jeffrey GP, Basclain KA, Thomas C, Morgan EH. Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet. Hepatology 15: 665-674, 2000.
27. Oates PS, Thomas C. Ferroportin is expressed on the mucous granule membrane of a subpopulation of goblet cells in the duodenum of the rat. Histol Histopathol 20: 681-687, 2005.
28. Oates PS, Thomas C. Ferroportin/IREG-1/MTP-1/SLC40A1 modulates the uptake of iron at the apical membrane of enterocytes. Gut 53: 44-49, 2004.
29. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819, 2001.
30. Ponka P. Cellular iron metabolism. Kidney Int 55: S2-S11, 1990.
31. Roque ME, Sandoval MJ, Aggio MC. Serum erythropoietin and its relation with soluble transferrin receptor in patients with different types of anaemia in a locally defined reference population. Clin Lab Haematol 23: 291-295, 2001.
32. Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46: 270-276, 2000.
33. Wareing M, Ferguson CJ, Delannoy M, Cox AG, McMahon RFT, Green R, Riccardi D, Smith CP. Altered dietary iron intake is a strong modulator of renal DMT1 expression. Am J Physiol Renal Physiol 285: F1050-F1059, 2003.
34. Wareing M, Ferguson CJ, Green R, Riccardi D, Smith CP. In vivo characterization of renal iron transport in the anaesthetized rat. J Physiol 524: 581-586, 2000.