Tetrandrine ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor - κB activation

International Journal of Colorectal Disease

Volumn 24, Issue 1, 2009, Pages 5-12

  Zhang, Dei Kui ^a   Cheng, Li Na ^a   Huang, Xiao Li ^a   Shi, Wei ^a   Xiang, Jun Ying ^a   Gan, Hua Tian ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Dextran sulfate sodium induced colitis; Nuclear factor (NF) B; Tetrandrine; Ulcerative colitis

Indexed keywords

DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MYELOPEROXIDASE; TETRANDRINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL MOBILITY SHIFT ASSAY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS;

ANIMALS; BENZYLISOQUINOLINES; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; NF-KAPPA B; PEROXIDASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57049165969     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-008-0544-7     Document Type: Article

References (55)

1. Podolsky DK (2002) Inflammatory bowel disease. N Engl J Med 347:417-429
2. Sands BE (2000) Therapy of inflammatory bowel disease. Gastroenterology 118:S68-S82
3. Katz JA (2002) Advances in the medical therapy of inflammatory bowel disease. Curr Opin Gastroenterol 18:435-440
4. Ardizzone S, Bianchi Porro G (2005) Biologic therapy for inflammatory bowel disease. Drugs 65:2253-2286
5. Reddy JG, Loftus EV Jr (2006) Safety of infliximab and other biologic agents in the inflammatory bowel diseases. Gastroenterol Clin North Am 35:837-855
6. Papadakis KA, Targan SR (2000) Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51:289-298
7. Rogler G, Andus T (1998) Cytokines in inflammatory bowel disease. World J Surg 22:382-389
8. Ogata H, Hibi T (2003) Cytokine and anti-cytokine therapies for inflammatory bowel disease. Curr Pharm Des 9:1107-1113
9. Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, Antonioli D, Peppercorn MA, Strom TB (1992) Tumor necrosis factor-a, interleukin-1, and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 37:818-826
10. Blackwell TS, Christman JW (1997) The role of nuclear factor-kB in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3-9
11. Tak PP, Firestein GS (2001) NF-kB: A key role in inflammatory disease. J Clin Invest 107:7-11
12. Neurath MF, Fuss I, Schurmann G, Pettersson S, Arnold K, Müller-Lobeck H, Strober W, Herfarth C, Büschenfelde KH (1998) Cytokine gene transcription by NF-kB family members in patients with inflammatory bowel disease. Ann NY Acad Sci 859:149-159
13. Baeuerle P, Henkel T (1994) Function and activation of NF-kB in the immune system. Annu Rev Immunol 12:141-153
14. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol 14:649-683
15. Finco T, Baldwin AS Jr (1995) Mechanistic aspects of NF-kB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3:263-272
16. Rogler G, Brand K, Vogl D, Page S, Hofmeister R, Andus T, Knuechel R, Baeuerle PA, Schölmerich J, Gross V (1998) Nuclear factor-kB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 115:537-569
17. Schreiber S, Nikolaus S, Hampe J (1998) Activation of nuclear factor-kB in inflammatory bowel disease. Gut 42:477-484
18. Chen YJ (2002) Potential role of tetrandrine in cancer therapy. Acta Pharmacol Sin 23:1102-1106
19. Kwan CY, Achike FI (2002) Tetrandrine and related bisbenzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action. Acta Pharmacol Sin 23:1057-1068
20. Lai JH (2002) Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol Sin 23:1093-1101
21. Shen YC, Chou CJ, Chiou WF, Chen CF (2001) Anti-inflammatory effects of the partially purified extract of radix Stephania tetrandra: Comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions. Mol Pharmacol 60:1083-1090
22. Kim HS, Zhang YH, Oh KW, Ahn HY (1997) Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat. J Ethnopharmacol 58:117-123
23. +-ATPase in renovascular hypertensive rats. Pharmacol Sin 12:488-493
24. Wang G, Lemos JR, Iadecola C (2004) Herbal alkaloid tetrandrine: From an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci 25:120-123
25. Meng LH, Zhang HL, Hayward L, Takemura H, Shao RG, Pommier Y (2004) Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. Cancer Res 64:9086-9092
26. Wu SJ, Ng LT (2007) Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells. Biol Pharm Bull 30:59-62
27. Ho LJ, Juan TY, Chao P, Wu WL, Chang DM, Chang SY, Lai JH (2004) Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell. Br J Pharmacol 143:919-927
28. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, Demers LM (1997) Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun 231:99-102
29. Zhang H, Li YY, Wu XZ (2006) Effect of tetrandrine on LPS-induced NF-kappaB activation in isolated pancreatic acinar cells of rat. World J Gastroenterol 12:4232-4236
30. Lin ST, Wang Y, Xue Y, Feng DC, Xu Y, Xu LY (2008) Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF-kappaB signaling pathway. Mol Cell Biochem 315:41-49
31. Huang YT, Cheng YR, Lin HC, Chen SM, Hong CY (1998) Haemodynamic effects of chronic octreotide and tetrandrine administration in portal hypertensive rats. J Gastroenterol Hepatol 13:266-272
32. Hsu YC, Chiu YT, Lee CY, Wu CF, Huang YT (2006) Anti-fibrotic effects of tetrandrine on bile-duct ligated rats. Can J Physiol Pharmacol 84:967-976
33. Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergran DJ (1993) Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci 38:1722-1734
34. Cooper HS, Murthy SN, Shah RS, Sedergran DJ (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238-249
35. ten Hove T, van den Blink B, Pronk I, Drillenburg P, Peppelenbosch MP, van Deventer SJ (2002) Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut 50:507-512
36. Gan HT, Chen YQ, Ouyan Q (2005) Sulfasalazine inhibits activation of nuclear factor-kB in patients with ulcerative colitis. J Gastroenterol. Hepatol 20:1016-1024
37. Cooper JA Jr, Parks JM, Carcelen R, Kahlon SS, Sheffield M, Culbreth R (2000) Attenuation of interleukin-8 production by inhibiting nuclear factor-kB translocation using decoy oligonucleotides. Biochem Pharmacol 59:605-613
38. Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF (2004) Joint cytokine quantification in two rodent arthritis models: Kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol 137:65-73
39. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702
40. Shen YC, Chen CF, Sung YJ (1999) Tetrandrine ameliorates ischaemia-reperfusion injury of rat myocardium through inhibition of neutrophil priming and activation. Br J Pharmacol 128:1593-1601
41. Li YY, Li XL, Yang CX, Zhong H, Yao H, Zhu L (2003) Effects of tetrandrine and QYT on ICAM-1 and SOD gene expression in pancreas and liver of rats with acute pancreatitis. World J Gastroenterol 9:155-159
42. Choi HS, Kim HS, Min KR, Kim Y, Lim HK, Chang YK, Chung MW (2000) Anti-inflammatory effects of fangchinoline and tetrandrine. J Ethnopharmacol 69:173-179
43. Seow WK, Thong YH (1993) Evaluation of the novel anti-inflammatory agent tetrandrine as a pulpotomy medicament in a canine model. Pediatr Dent 15:260-266
44. Cho JY, Chang HJ, Lee SK, Kim HJ, Hwang JK, Chun HS (2007) Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of b-caryophyllene, a sesquiterpene. Life Sciences 80:932-939
45. Ohkawara T, Takeda H, Kato K, Miyashita K, Kato M, Iwanaga T, Asaka M (2005) Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice. Scand J Gastroenterol 40:1321-1327
46. Woo P (2000) Cytokine polymorphisms and inflammation. Clin Exp Rheumatol 18:767-771
47. Mantovani A, Muzio M, Garlanda C, Sozzani S, Allavena P (2001) Macrophage control of inflammation: Negative pathways of regulation of inflammatory cytokines. Novartis Found Symp 234:120-131
48. Nakamura K, Honda K, Mizutani T, Akiho H, Harada N (2006) Novel strategies for the treatment of inflammatory bowel disease: Selective inhibition of cytokines and adhesion molecules. World J Gastroenterol 12:4628-4635
49. Venkatraman A, Ramakrishna BS, Shaji RV, Kumar NS, Pulimood A, Patra S (2003) Amelioration of dextran sulfate colitis by butyrate role of heat shock protein 70 and NF-kB. Am J Physiol Gastrointest Liver Physiol 285:177-184
50. Blumberg RS, Saubermann LJ, Strober W (1999) Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 11:648-656
51. Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT (2005) Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol 206:260-276
52. Ng LT, Chiang LC, Lin YT, Lin CC (2006) Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines. Am J Chin Med 34:125-135
53. Eaden JA, Abrams KR, Mayberry JF (2001) The risk of colorectal cancer in ulcerative colitis: A meta-analysis. Gut 48:526-535
54. Xie QM, Tang HF, Chen JQ, Bian RL (2002) Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin 23:1107-1113
55. Rao MR (2002) Effects of tetrandrine on cardiac and vascular remodeling. Acta Pharmacol Sin 23:1075-1085