Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins

Microscopy and Microanalysis

Volumn 8, Issue 2, 2002, Pages 81-93

  Yancey, Patricia G ^a   Miles, Stacia ^a   Schwegel, Jennifer ^a   Jerome, W Gray ^a,b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Cholesterol; Colloidal gold; Endocytosis; Foam cell; LDL; Lipoprotein trafficking; Lysosome; Microscopy; Oxidation

Indexed keywords

ANIMAL; CELL LINE; CELLS, CULTURED; ENDOCYTOSIS; FOAM CELLS; HUMAN; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED STRAINS; POLYSACCHARIDES; PROTEIN TRANSPORT; STAINING AND LABELING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HUMANS;

ACETYL LOW DENSITY LIPOPROTEIN; ACETYL-LDL; FUCOIDIN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYSACCHARIDE;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; ENDOCYTOSIS; FOAM CELL; HUMAN; LYSOSOME; MACROPHAGE; METABOLISM; MOUSE; MOUSE STRAIN; PROTEIN TRANSPORT; STAINING; ULTRASTRUCTURE;

EID: 0036023360     PISSN: 14319276     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1431927601020013     Document Type: Article

References (48)

1. New insights into apolipoprotein B and low density lipoprotein physiology; implications for atherosclerosis
2. Modified forms of low density lipoprotein and atherosclerosis
3. Characterization of plasma lipoproteins of grain- and cholesterol-fed white carneau and show racer pigeons
4. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous hypercholesterolemia fibroblasts
5. 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque
6. Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein
7. Receptor-mediated endocytosis: Insights from the lipoprotein receptor system
8. Lipoprotein metabolism in the macrophage
9. A receptor mediated pathway for cholesterol homeostasis
10. Biogenesis of phagolysosomes: The kiss and run hypothesis
11. CD36 is a receptor for oxidized low density lipoprotein
12. Homeostasis in lipid oxidation in the artery wall
13. Characterization of cell populations isolated from aortas of rhesus monkeys with experimental atherosclerosis
14. Controlled nucleation for the regulation of particle size in monodisperse gold suspensions
15. An improved histochemical technique for acid phosphatase
16. Colloidal gold-low density lipoprotein conjugates as membrane receptor probes
17. Morphological characterization of b-VLDL and acetylated-LDL binding and internalization by cultured pigeon monocytes
18. Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages
19. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network
20. Early atherogenesis in White Carneau pigeons II: Ultrastructural and cytochemical observations
21. Early atherogenesis in White Carneau pigeons III: Lipid accumulation in nascent foam cells
22. Early atherogenesis in White Carneau pigeons. Effect of a short-term regression diet
23. Lysosomal lipid accumulation in vascular smooth muscle cells
24. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages
25. Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages
26. High-affinity saturable uptake of oxidized low density lipoprotein by macrophages from mice lacking the scavenger receptor class A type I/II
27. Uptake of oxidized LDL by macrophages differs from that acetyl LDL and leads to expansion of an endolysosomal compartment
28. Mechanism of uptake of copper-oxidized low density lipoprotein in macrophages is dependent on its extent of oxidation
29. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages
30. Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol
31. Increased activity of lysosomal enzymes in human atherosclerotic aortas
32. Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages
33. Endocytosis of oxidized LDL and reversibility of migration inhibition in macrophage-derived foam cells in vitro. A mechanism for atherosclerosis regression?
34. Cell surface expression of mouse microsialin and human CD68 and their roles as macrophage receptors for oxidized low density lipoprotein
35. Defective catabolism of oxidized LDL by J774 murine macrophages
36. Characterization of lipid-laden aortic cells from cholesterol-fed rabbits II. Morphometric analysis of lipid-filled lysosomes and lipid droplets in aortic cell populations
37. A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein
38. A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein
39. Oxidized low density lipoprotein - An extreme example of lipoprotein heterogeneity
40. Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation
41. The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?
42. Endocytosed β-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages
43. The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of β-VLDL in mouse
44. Practical stereological methods for morphometric cytology
45. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species
46. Cholesterol efflux is defective in macrophages from atherosclerosis-susceptible White Carneau pigeons relative to resistant Show Racer pigeons
47. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man