Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3435-3439

  Maruoka, Hiroshi ^a   Muto, Tsuyoshi ^a   Tanaka, Taisaku ^a   Imajo, Seiichi ^a   Tomimori, Yoshiaki ^a   Fukuda, Yoshiaki ^a   Nakatsuka, Takashi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Chymase; Inhibitor

Indexed keywords

AMINE; BENZYL DERIVATIVE; CARBONYL DERIVATIVE; CHYMASE; CHYMASE INHIBITOR; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN; QUANTUM YIELD; SKIN INFLAMMATION; STRUCTURE ACTIVITY RELATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANIMALS; AZEPINES; BENZYL COMPOUNDS; BINDING SITES; CHYMASES; DERMATITIS; DISEASE MODELS, ANIMAL; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249300496     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.085     Document Type: Article

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