Cytokines, chemokine receptors, CD4+CD25HIGH+ T-cells and clinical forms of human schistosomiasis

Acta Tropica

Volumn 108, Issue 2-3, 2008, Pages 139-149

  Teixeira Carvalho, Andréa ^a,b,c   Martins Filho, Olindo Assis ^a   Peruhype Magalhães, Vanessa ^a   Silveira Lemos, Denise ^a,c   Malaquias, Luiz Cosme Cotta ^d   Oliveira, Lúcia Fraga Alves ^d   Silveira, Alda Maria Soares ^d   Gazzinelli, Andréa ^c   Gazzinelli, Giovanni ^e   Corrêa Oliveira, Rodrigo ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d UNIVERSIDADE VALE DO RIO DOCE   (Brazil)

^e Pós graduação em Biomedicina ^*  (Brazil)

Author keywords

CD4+CD25HIGH+ T cells; Chemokine receptors; Cytokines; Flow cytometry; Periportal fibrosis; Schistosomiasis

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY; PARASITE ANTIGEN;

CYTOLOGY; FLOW CYTOMETRY; IMMUNE RESPONSE; SCHISTOSOMIASIS;

ADOLESCENT; ADULT; ARTICLE; BLOOD CULTURE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; EOSINOPHIL COUNT; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOREGULATION; LEUKOCYTE COUNT; LIVER FIBROSIS; MALE; MONOCYTE; MORBIDITY; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHILD; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; RECEPTORS, CHEMOKINE; SCHISTOSOMIASIS;

EID: 56949089096     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2008.04.010     Document Type: Article

References (56)

1. Abdel-Wahab M.F., Esmat G., Farrag A., el-Boraey Y.A., and Strickland G.T. Grading of hepatic schistosomiasis by the use of ultrasonography. Am. J. Trop. Med. Hyg. 46 (1992) 403-408
2. Araújo M.I., de Jesus A.R., Bacellar O., Sabin E., Pearce E., and Carvalho E.M. Evidence of a T helper Type 2 activation in human schistosomiasis. Eur. J. Immunol. 26 (1996) 1399-1403
3. Baecher-Allan C., Brown J.A., Freeman G.J., and Hafler D.A. CD4+CD25 high regulatory cells in human peripheral blood. J. Immunol. 167 (2001) 1245-1253
4. Bahia-Oliveira L.M.G., Gazzinelli G., Eloi-Santos S.M., Cunha-Melo J.R., Alves-Oliveira L.F., Silveira A.M.S., Viana I.R.C., Carmo J., Souza A., and Corrêa-Oliveira R. Differential cellular reactivity to adult worm antigens of patients with different clinical forms of Schistosomiasis mansoni. Trans. Roy. Soc. Trop. Med. Hyg. 86 (1992) 57-61
5. Bahia-Oliveira L.M., Simpson A.J., Alves-Oliveira L.F., Carvalho-Queiroz C., Silveira A.M., Viana I.R., Cunha-Melo J.R., Hagan P., Gazzinelli G., and Correa-Oliveira R. Evidence that cellular immune responses to soluble and membrane associated antigens are independently regulated during human Schistosomiasis mansoni. Parasite Immunol. 18 (1996) 53-63
6. Bogliolo L. Anatomical bases of hepatosplenic Schistosomiasis mansoni (the hepatosplenic form of schistosomiasis) and their clinical applications. Resen. Clin. Cient. 27 (1958) 86-93
7. Borkow G., Leng Q., Weisman Z., Stein M., Galai N., Kalinkovich A., and Bentwich Z. Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy. J. Clin. Invest. 106 (2000) 1053-1060
8. Brazilian Ministry of Health, 1998. Controle da esquistossomose: diretrizes técnicas, 2nd ed. Brasília, Fundação Nacional de Saúde, Ministério da Saúde, Brazil, 70 pp.
9. Brunet L.R., Finkelman F.D., Cheever A.W., Kopf M.A., and Pearce E.J. IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. J. Immunol. 159 (1997) 777-785
10. Colley D.G., Garcia A.A., Lambertucci J.R., Parra J.C., Katz N., Rocha R.S., and Gazzinelli G. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am. J. Trop. Med. Hyg. 35 (1986) 793-802
11. Cone R.E., Li X., Sharafieh R., O'rourke J., and Vella A.T. The suppression of delayed-type hypersensitivity by CD8 regulatory T cells requires interferon-gamma. Immunology 120 (2007) 112-119
12. Contigli C., Silva-Teixeira D.N., Del Prete G., D'elios M.M., De Carli M., Manghetti M., Amedei A., Almerigogna F., Lambertucci J.R., and Goes A.M. Phenotype and cytokine profile of Schistosoma mansoni specific T cell lines and clones derived from schistosomiasis patients with distinct clinical forms. Clin. Immunol. 91 (1999) 338-344
13. Corrêa-Oliveira R., Malaquias L.C., Falcao P.L., Viana I.R., Bahia-Oliveira L.M., Silveira A.M., Fraga L.A., Prata A., Coffman R.L., Lambertucci J.R., Cunha-Melo J.R., Martins-Filho O.A., Wilson R.A., and Gazzinelli G. Cytokines is a determinant of the susceptibility and resistance in human Schistosomiasis mansoni. Braz. Med. Biol. Res. 31 (1998) 127-131
14. Da Silva L.C., Chieffi P.P., and Carrilho F.J. Schistosomiasis mansoni-clinical features. Gastroenterol. Hepatol. 28 (2005) 30-39
15. Den Haan J.M., and Bevan M.J. Antigen presentation to CD8+ T cells: cross-priming in infectious diseases. Curr. Opin. Immunol. 13 (2001) 437-441
16. Dessein A.J., Hillaire D., Elwali N.E., Marquet S., Mohamed-Ali Q., Mirghani A., Henri S., Abdelhameed A.A., Saeed O.K., and Magzoub M.M. Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene. Am. J. Hum. Genet. 65 (1999) 709-721
17. Doughty B.L., and Philips S.M. Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. II. Regulatory T cell subsets. J. Immunol. 133 (1982) 933-940
18. Falcão P.L., Malaquias L.C., Martins-Filho O.A., Silveira A.M., Passos V.M., Prata A., Gazzinelli G., Coffman R.L., and Correa-Oliveira R. Human Schistosomiasis mansoni: IL-10 modulates the in vitro granuloma formation. Parasite Immunol. 20 (1998) 447-454
19. Flores-Villanueva P.O., Reiser H., and Stadecker M.J. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages. J. Immunol. 153 (1994) 5190-5199
20. Gazzinelli G., Katz N., Rocha R.S., and Colley D.G. Immune responses during human Schistosomiasis mansoni. X. Production and standardization of an antigen-induced mitogenic activity by peripheral mononuclear cells from treated, but not active cases of schistosomiasis. J. Immunol. 135 (1983) 2981-2985
21. Grant E.P., and Rock K.L. MHC class I-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo. J. Immunol. 148 (1992) 13-18
22. Goes A.M., Rezende S.A., Gazzinelli G., and Doughty B.L. Granulomatous hypersensitivity to Schistosoma mansoni egg antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation. Parasite Immunol. 16 (1994) 11-18
23. Grzych J.M., Pearce E.J., Cheever A., Caulada Z.A., Caspar P., Heiny S., Lewis F., and Sher A. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis. J. Immunol. 146 (1991) 1322-1327
24. Hesse M., Piccirillo C.A., Belkaid Y., Prufer J., Mentink-Kane M., Leusink M., Cheever A.W., Shevach E.M., and Wynn T.A. The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J. Immunol. 172 (2004) 3157-3166
25. Hoffmann K.F., Cheever A.W., and Wynn T.A. IL-10 and the dangers of immune polarization: excessive Type 1 and Type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J. Immunol. 164 (2000) 6406-6416
26. Kalinkovich A., Weisman Z., Greenberg Z., Nahmias J., Eitan S., Stein M., and Bentwich Z. Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection. Clin. Exp. Immunol. 114 (1998) 414-421
27. Katz N., Chaves A., and Pellegrino J.A. simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. ver. Inst. Med. Trop. São Paulo 14 (1972) 397-400
28. Kim C.H. Chemokine-Chemokine receptor network in immune cell trafficking. Curr. Drug Targets Immune Endocr. Metabol. Disord. 4 (2004) 343-361
29. Larsson, M., Fonteneau, J.F., Somersan, S., Sanders, C., Bickham, K., Thomas, E.K., Mahnke, K., Bhardwaj, N., 2001. Efficiency of cross presentation of vaccinia virus-derived antigens by human dendritic cells. Eur. J. Immunol, 31, 3432-3442 (Erratum in Eur. J. Immunol. 32, 307, 2002).
30. Magalhães T.V., Gazzinelli G., Alvarez M.C., Lima e Silva F.C., Fraga L.A., Silveira A.M., Gazzinelli A., Bethony J., LoVerde P., Caldas I.R., Correa-Oliveira R., and Prata A. Comparative clinical and ultrasound study of egg-negative and egg-positive individuals from Schistosoma mansoni low morbidity endemic areas, and hospitalized patients with hepatosplenic disease. Rev. Soc. Bras. Med. Trop. 38 (2005) 33-37
31. Malaquias L.C., Falcao P.L., Silveira A.M.S., Gazzinelli G., Prata A., Coffman R.L., Pizziolo V., Souza C.P., Colley D.G., and Corrêa-Oliveira R. Cytokine regulation of human immune response to Schistosoma mansoni analysis of the role of IL-4, IL-5 and IL-10 on peripheral blood mononuclear cell responses. Scand. J. Immunol. 46 (1997) 393-398
32. Manfras B.J., Reuter S., Wendland T., and Kern P. Increased activation and oligoclonality of peripheral CD8(+) T cells in the chronic human helminth infection alveolar echinococcosis. Infect. Immun. 70 (2002) 1168-1174
33. Martins-Filho O.A., Cunha-Mello J.R., and Corrêa-Oliveira R. The spleen is an important site of T cell activation during human hepatosplenic schistosomiasis. Mem. Inst. Osw. Cruz 93 (1998) 159-164
34. Martins-Filho O.A., Cunha-Mello J.R., Lambertucci J.R., Silveira A.M.S., Colley D.G., Gazzinelli G., and Corrêa-Oliveira R. Clinical forms to human Schistosoma mansoni infection are associated with differential activation of T-cell subsets and co-stimulatory molecules. Digest. Dis. Sci. 44 (1999) 570-577
35. Mjosberg J., Berg G., Ernerudh J., and Ekerfelt C. CD4(+) CD25(+) regulatory T cells in human pregnancy: development of a T-MLC-ELISPOT suppression assay and indications of paternal specific Tregs. Immunology 120 (2007) 456-466
36. Montenegro S.M., Miranda P., Mahanty S., Abath F.G., Teixeira K.M., Coutinho E.M., Brinkman J., Gonçalves I., Domingues L.A., Domingues A.L., Sher A., and Wynn T.A. Cytokine production in acute versus chronic human Schistosomiasis mansoni: the cross-regulatory role of interferon-gamma and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. J. Infect. Dis. 179 (1999) 1502-1514
37. Murdoch C., and Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood 95 (2000) 3032-3043
38. Mwatha J.K., Kimani G., Kamau T., Mbugua G.G., Ouma J.H., Mumo J., Fulford A.J., Jones F.M., Butterworth A.E., Roberts M.B., and Dunne D.W. High levels of TNF-alpha, soluble TNF-alpha receptors, soluble ICAM-1 and INF-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human Schistosomiasis mansoni. J. Immunol. 160 (1998) 1992-1999
39. Ottesen E.A. Modulation of the host response in human schistosomiasis. I. Adherent suppressor cells that inhibit lymphocyte proliferation responses to parasite antigens. J. Immunol. 123 (1979) 1639-1644
40. Patterson B.K., Czerniewski M., Andersson J., Sullivan Y., Su F., Jiyamapa D., Burki Z., and Landay A. Regulation of CCR5 and CXCR4 expression by Type 1 and Type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes. Clin. Immunol. 91 (1999) 254-262
41. Pearce E.J., Caspar P., Grzych J.M., Lewis F.A., and Sher A. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173 (1991) 159-162
42. Prata A., and Bina J.C. Development of hepatosplenic form of schistosomiasis: a study of 20 patients observed during a 5-year period. Gaz. Med. Bahia 68 (1968) 49-60
43. Putheti P., Morris M., Stawiarz L., Teleshova N., Kivisakk P., Pashenkov M., Kouwenhoven M., Wiberg M.K., Bronge L., Huang Y.M., Soderstrom M., Hillert J., and Link H. Multiple sclerosis: a study of chemokine receptors and regulatory T cells in relation to MRI variables. Eur. J. Neurol. 10 (2003) 529-535
44. Raso, P., 1994. Esquistossomose mansônica. In: Bogliolo, L. (Ed.), Patologia, 4th ed. Guanabara Koogan, Rio de Janeiro, pp. 534-545.
45. Raso P., and Neves J. Contribuição ao conhecimento do quadro anatômico do fígado na forma toxêmica da esquistossomose mansoni através de punções-biópsias. Ann. Fac. Med. UFMG 22 (1965) 147-165
46. Rezende S.A., Silva-Teixeira D.N., Drummond S.C., and Goes A.M. IL-10 plays a role in the modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes. Scand. J. Immunol. 46 (1997) 96-102
47. Rock K.L., Gamble S., Rothstein L., and Benacerraf B. Reassociation with beta 2-microglobulin is necessary for Db class I major histocompatibility complex binding of an exogenous influenza peptide. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 301-304
48. Rock K.L., Rothstein L., Gamble S., and Fleischacker C. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 150 (1993) 438-446
49. Sallusto F., Lanzavecchia A., and Mackay C.R. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol. Today 12 (1998) 568-574
50. Stadecker M.J., and Flores-Villanueva P.O. Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease. Immunol. Today 15 (1994) 571-574
51. Sun J.B., Raghavan S., Sjoling A., Lundin S., and Holmgren J. Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25-CD4+ regulatory T cells. J. Immunol. 177 (2006) 7634-7644
52. Teixeira-Carvalho A., Martins-Filho O.A., Andrade Z.A., Cunha-Mello J.R., Wilson R.A., and Correa-Oliveira R. The study of T-cell activation in peripheral blood and spleen of hepatosplenic patients suggests an exchange of cells between these two compartments in advanced human Schistosomiasis mansoni infection. Scand. J. Immunol. 56 (2002) 315-322
53. Viana I.R.C., Sher A., Carvalho O.S., Massara C.L., Eloi-Santos S.M., Pearce E.J., Colley D.G., Gazzinelli G., and Corrêa-Oliveira R. Interferon-γ production by peripheral blood mononuclear cells from resident of an area endemic for Schistosoma mansoni. Trans. Roy. Soc. Trop. Med. Hyg. 88 (1994) 466-470
54. Wang J., Ioan-Facsinay A., van der Voort E.I., Huizinga T.W., and Toes R.E. Transient expression of FOXP3 in human activated nonregulatory CD4(+) T cells. Eur. J. Immunol. 37 (2007) 129-138
55. Warren, K.S., 1979. The pathogenesis of hepatosplenic schistosomiasis: from man to monkey to mouse to molecule. In: Popper, H., Schaffner, F. (Eds.), Progress in Liver Disease, vol. 6. Grune and Straffon, New York, pp. 439-455.
56. Zwingenberger K., Irschick E., Siqueira Vergetti J.G., Correia Dacal A.R., Janssen-Rosseck R., Bienzle U., Huber C., and Feldmeier H. Release of interleukin-2 and Interferon-gamma by peripheral blood cells in human S. mansoni infection normalizes after chemotheraphy. Scand. J. Immunol. 30 (1989) 463-471