Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection

Clinical and Experimental Immunology

Volumn 114, Issue 3, 1998, Pages 414-421

  Kalinkovich, A ^a   Weisman, Z ^a   Greenberg, Z ^b   Nahmias, J ^c   Eitan, S ^a   Stein, M ^a   Bentwich R , Z ^a,d  

^a HEBREW UNIVERSITY   (Israel)

^b MINISTRY OF HEALTH   (Israel)

^c Kupat Holim   (Israel)

^d KAPLAN MEDICAL CENTER   (Israel)

Author keywords

Chronic immune activation; Ethiopian immigrants; Helminth infection; T cell subsets

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

APOPTOSIS; ARTICLE; ETHIOPIA; HELMINTHIASIS; HELPER CELL; HUMAN; INCIDENCE; INFECTION RESISTANCE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGENS, CD; APOPTOSIS; BIOLOGICAL MARKERS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; HELMINTHIASIS; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; T-LYMPHOCYTE SUBSETS;

EID: 0031736997     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00736.x     Document Type: Article

References (60)

1. Edman R, Greenberg Z. Intestinal parasitic infection in operation Solomon immigrants. J Isr Med Sci 1993; 29:374-6.
2. Nahmias J, Greenberg Z, Berger SA, Hornstein L, Bilgury B, Abel B, Kutner S. Health profile of Ethiopian immigrants in Israel: an overview. Isr J Med Sci 1993; 29:338-43.
3. Bentwich Z, Weisman Z, Moroz C, Bar-Yehuda S, Kalinkovich A. Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections. Clin Exp Immunol 1996; 103:239-43.
4. Beaver PC, Jung RC, Cupp EW. Examination of specimens for parasites. In: Clinical parasitology. Philadelphia: Lea & Febiger, 1984:733-58.
5. Knight WB, Hiatt RA, Cline BJ, Richie LS. A modification of the formol-ether concentration technique for increased sensitivity in detecting Schistosoma mansoni eggs. Am J Trop Med Hyg 1976; 25:818-23.
6. Harada Y, Mori O. A new method for culturing hookworm. Yonago Acta Med 1955; 1:177-9.
7. Pollack S, Fuad B, Etzioni A. CD4 T-lymphocytopenia without opportunistic infections in HIV-seronegative Ethiopian immigrants to Israel. Lancet 1993; 342:50-51.
8. Worku S, Bjorman A, Troye-Blomberg M, Jemaneh L, Farnert A. Christensson B. Lymphocyte activation and subset redistribution in the peripheral blood in acute malaria illness: distinct γδ+ T cell patterns in Plasmodium falciparum and P. vivax infections. Clin Exp Immunol 1997; 108:34-41.
9. Egboga A, Corrah T, Todd J. Immunological findings in African patients with pulmonary tuberculosis and HIV-2 infection. AIDS 1992; 6:1045-6.
10. + T-lymphocyte depletion in a West African population. AIDS 1994; 8:843-7.
11. + lymphocyte count in African patients co-infected with HIV and tuberculosis. J Acqiur Immune Defic Syndr Hum Retrovir 1995; 8:386-91.
12. Soboslay PT, Dreweck CM, Hoffmann WH et al. Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment. Clin Exp Immunol 1992; 89:407-13.
13. Carney WP, Rubin RH, Hoffman RA, Hansen WP, Healey K, Hirsh MS. Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis. J Immunol 1981; 126:2114-6.
14. Thomas HC, Brown D, Routhier G et al. Inducer and suppressor T-cells in hepatitis B virus-induced liver disease. Hepatology 1982; 2:202-4.
15. Gomez E, Albercu I, Gonzalez M, Zaballos R, Vicente V. Effect of hepatitis C virus infection on the lymphoid population in hemophiliacs. Blood 1991; 77:1399-400.
16. Williams RC, Koster FT, Kilpatrick KA. Alterations in lymphocyte cell surface markers during various human infections. Am J Med 1983; 75:807-16.
17. Pankhurst C, Peakman M. Reduced CD4+ T cells and oral candidiasis in absence of HIV infection. Lancet 1989; i:1027-8.
18. + helper/inducer T lymphocytes in a patient with widespread human papillomavirus type 3-related infection. Arch Dermatol 1990; 126:1604-8.
19. + lymphocytopenia in the absence of HIV infection in a patient with visceral leishmaniasis. N Engl J Med 1990; 322:132.
20. + lymphocytopenia without HIV in patient with cryptococcal disease. Lancet 1991; 338:57-58.
21. Leon ME, Ward B, Kanashiro R et al. Immunologic parameters 2 years after high-titer measles immunization in Peruvian children. J Infect Dis 1993; 168:1097-104.
22. + T-lymphocytopenia - four patients with opportunistic infections and no evidence of HIV infection. N Engl J Med 1993; 328:393-8.
23. + T-lymphocyte depletion in patients without HIV infection treated for tuberculosis. Chest 1994; 105:1335-7.
24. + T lymphocytopenia. Ann Intern Med 1993; 119:55-62.
25. Urassa W, Pallangyo K, Lyamuya E et al. Variability of levels of peripheral leukocytes, lymphocyte subsets and beta-2 microglobulin (B-2M) in HIV-1 seronegative adults. 3rd Federation of African Immunological Societies Congress (FAIS), 9-13 March 1997; Cape Town, South Africa, Abstract book.
26. Quinn TC, Piot P, McCormick JB et al. Serologic and immunologic studies in patients with AIDS in North America and Africa. The potential role of infectious agents as cofactors in human immunodeficiency virus infection. JAMA 1987; 257:2617-21.
27. Katzenstein DA, Latif AS, Grace SA et al. Clinical and laboratory characteristics of HIV-1 infection in Zimbabwe. J Acquir Immune Defic Syndr 1990; 3:701-7.
28. Le Guenno BM, Barabe P, Griffet PA et al. HIV-2 and HIV-1 AIDS cases in Senegal: clinical patterns and immunological perturbations. J Acquir Immune Defic Syndr 1991; 4:421-7.
29. Kestens L, Brattegaard K, Adjorlolo G et al. Immunological comparison of HIV-1, HIV-2 and dually-reactive women delivering in Abidjan, Cote d'Ivore. AIDS 1992; 6:803-7.
30. Whittle H, Egboga A, Todd J et al. Immunological responses of Gambians in relation to clinical stage of HIV-2 disease. Clin Exp Immunol 1993; 93:45-50.
31. Chollet-Martin S, Simon F, Matheron S, Joseph CA, Elbim C, Gougerot-Pocidalo MA. Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection. AIDS 1994; 8:879-84.
32. Thea DM, Porat R, Nagimbi K et al. Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann Intern Med 1996; 124:757-62.
33. + lymphocytes during HIV infection. Scand J Immunol 1994; 40:485-90.
34. Saukkonen JJ, Kornfeld H, Berman JS. Expansion of CD8+CD28- cell population in the blood and lung of HIV-positive patients. J Aquir Immune Defic Syndr 1993; 6:1194-204.
35. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994; 169:730-8.
36. Borthwick NJ, Bofill M, Gombert WM et al. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. AIDS 1994; 8:431-41.
37. + lymphocyte phenotype and cytokine production in long-lerm non-progressor and in progressor patients with HIV-1 infection. Clin Exp Immunol 1996; 105:220-4.
38. +CD28 T cell expansion - anergy or activation? Clin Exp Immunol 1996; 104:180-4.
39. + T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis. Clin Exp Immunol 1996; 106:18-29.
40. + T cell apoptosis in patients with acute herpes-virus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression. Immunology 1996; 88:508-15.
41. Dutra WO, Martins-Filho OA, Cancado JR et al. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand J Immunol 1996; 43:88-93.
42. Bentwich Z, Kalinkovich A, Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 1995; 16:187-91.
43. Bentwich Z, Weisman Z, Grossman Z, Galai N, Kalinkovich A. Pathogenesis of AIDS in Africa: lessons from the Ethiopian immigrants in Israel. Immunologist 1997; 5:21-26.
44. Vanham G, Kestents L, Penne G et al. Subset markers of CD8 (+) cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection. J Clin Immunol 1941; 11:345-56.
45. Prince HE, Jensen ER. Three-color cytofluorimetric analysis of CD8 cell subsets in HIV-1 infection. J Acquir Immune Defic Syndr 1991; 4:1227-32.
46. Mahalingham M, Peakman M, Davies ET, Pozniak A, McManus TJ, Vergani D. T cell activation and disease severity in HIV infection. Clin Exp Immunol 1993; 93:337-43.
47. + T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol 1993; 69:106-16.
48. Benito JM, Zabay JM, Gil J et al. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR and CD25 antigens. J Acquir Immune Def Syndr Hum Retrovir 1997; 14:128-35.
49. Bentwich Z, Kalinkovich A, Weisman Z, Grossman Z. Immune activation in the context of HIV infection. Clin Exp Immunol 1998; 111:1-2.
50. Freedman DO, Lujan-Trangay A, Steel C. Gonzalez-Peralta C, Nutman TB. Immunoregulation in onchocerciasis. Functional and phenotypic abnormalities in lymphocyte subsets and changes with therapy. J Clin Invest 1991; 88:231-8.
51. Munk ME, Soboslay PT, Amoldi J, Brattig N, Schulz-Key H, Kaufmann SH. Onchocerca volvulus provides ligands for the stimulation of human γδT lymphocytes expressing VδI chains. J Infect Dis 1993; 168:1241-7.
52. Soboslay PT, Luder CGK, Hoffmann WH et al. Ivermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection. Clin Exp Immunol 1994; 96:238-44.
53. Islam D, Bardhan PK, Lindberg AA, Christensson B. Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subset during the course of the disease. Infect Immun 1995; 63:2941-9.
54. Dutra WO, Martins-Filho OA, Cancado JR et. al Activated T and B lymphocytes in peripheral blood of patients with Chagas disease. Int Immunol 1994; 6:499-506.
55. Sabin EA, Araujo Carvalho EM, Pearce EJ. Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni. J Infect Dis 1996; 173:269-72.
56. Araujo MI, de Jesus AR, Bacellar O, Sabin E, Pearce E, Carvalho EM. Evidence of a T helper type 2 activation in human schistosomiasis. Eur J Immunol 1996; 26:1399-403.
57. Martins-Filho OA, Dutra WO, Freeman GL et al. Flow cytometrik study of blood leukocytes in clinical forms of human schistosomiasis. Scand J Immunol 1997; 46:304-11.
58. Rizzardini G, Piconi S, Ruzzante S et al. Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals. AIDS 1996; 10:1535-42.
59. Kalinkovich A, Maayan S, Weisman Z, Harpaz N, Bentwich Z. Immune activation, a cofactor for HIV transmission in Thailand? Lancet 1994; 343:1506-7.
60. Sundar S, Reed SG, Sharma S, Mehrotra A, Murray HW. Circulating T helper 1 (ThI) cell- and Th2 cell-associated cytokines in Indian patients with vísceral leishmaniasis. Am J Trop Med Hyg 1997; 56:522-5.