Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes

Clinical Immunology

Volumn 91, Issue 3, 1999, Pages 254-262

  Patterson, Bruce K ^a   Czerniewski, Maryann ^b   Andersson, Jan ^c   Sullivan, Yvonne ^b   Su, Felice ^a   Jiyamapa, Daniel ^a   Burki, Zareefa ^a   Landay, Alan ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

AIDS HIV; Chemokine receptors; Cytokines; Gene regulation; Th1 Th2

Indexed keywords

CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; DISEASE COURSE; DISEASE TRANSMISSION; DNA PURIFICATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MOLECULAR CLONING; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

EID: 0032969503     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1999.4713     Document Type: Article

References (35)

1. +. Ann. Intern. Med. 126:1997;946-954.
2. Schuitemaker H., Koostra N., deGoede R., de Wolf R., Miedema F., Tersmette M. Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable at all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J. Virol. 65:1991;356-363.
3. Cornelissen M., Mulder-Kampigna G., Veenstra J., Zorgdrager F., Kuiken C., Hartman S., Dekker J., van der Hoek L., Sol C., Coutinho R., Goudsmit J. Syncytium-inducing SI phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population. J. Virol. 69:1995;1810-1818.
4. Clerici M., Balotta C., Salvaggio A., Riva C., Trabattoni D., Papagno L., Berusconi A., Rusconi S., Luisa Villa M., Moroni M., Galli M. Human immunodeficiency virus (HIV) phenotype and interleukin-2/interleukin-10 ratio are associated markers of protection and progression in HIV infection. Blood. 88:1996;574-579.
5. Alkhatib G., Combadiere C., Broder C. C., Feng Y., Kennedy P. E., Murphy P. M., Berger E. A. CC-CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 272:1996;1955-1958.
6. Feng Y., Broder C. C., Kennedy P. E., Berger E. A. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 272:1996;872-877.
7. Connor R. I., Sheridan K. E., Ceradini D., Choe S., Landau N. R. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:1997;621-628.
8. Bleul C. C., Wu L., Hoxie J. A., Springer T. A., Mackay C. R. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T-lymphocytes. Proc. Natl. Acad. Sci. USA. 94:1997;1925-1930.
9. Granelli-Piperno A., Moser B., Pope M., Chen D., Wei Y., Isdell F., O'Doherty U., Paxton W., Koup R., Mojsov S., Bhardwaj N., Clark-Lewis I., Baggiolini M., Steinman R. M. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J. Exp. Med. 184:1997;2433-2438.
10. Loetscher P., Seitz M., Baggiolini M., Moser B. J. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T-lymphocytes. J. Exp. Med. 184:1996;569-578.
11. Sallusto, F. Lenig, D. Mackay, C. R. Lanzavecchia, A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes, J. Exp. Med. 187, 875, 883.
12. Valentin A., Lu W., Rosati M., Schneider R., Albert J., Karlsson A., Pavlakis G. N. Dual effect of interleukin 4 on HIV-1 Expression: Implications for viral phenotypic switch and disease progression. Proc. Natl. Acad. Sci. USA. 95:1998;8886-8891.
13. Tang S. B., Levy J. A. Inactivation of HIV-1 by trypsin and its use in demonstrating specific virus infection of cells. J. Virol. Methods. 33:1991;39-46.
14. Tang S., Patterson B., Levy J. A. Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation. J. Virol. 69:1995;5659-5665.
15. Patterson B. K., Jiyamapa D., Mayrand E., Hoff B., Abramson R., Garcia P. Detection of HIV-1 DNA in cells and tissue by fluorescence in situ 5′-nuclease assay (FISNA). Nucleic Acids Res. 18:1996;3656-3658.
16. Gibson U. E. M., Heid C. A., Williams P. M. A novel method for real time quantitative RT-PCR. Genome Res. 6:1996;995-1001.
17. Gao J., Murphy P. M. Human cytomegalovirus open reading frame US 28 encodes a functional β-chemokine receptor. J. Biol. Chem. 269:1994;28539-28542.
18. Kasama T., Streiter R. M., Lukacs N. W., Burdick M. D., Kunkel S. L. Regulation of neutrophil-derived chemokine expression by IL-10. J. Immunol. 152:1994;3559-3569.
19. Fiorentino D. F., Bond M. W., Mosmann T. R. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:1989;2081-2095.
20. Clerici M., Shearer G. M. The Th1-Th2 hypothesis of HIV infection: New insights. Immunol. Today. 15:1994;575-582.
21. Zhu T., Wang N., Carr A., Nam D. S., Moor-Jankowski R., Cooper D. A., Ho D. D. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: Evidence for viral compartmentalization and selection during sexual transmission. J. Virol. 70:1996;3098-3107.
22. Wolinsky S. M., Wike C. M., Korber B. T., Hutto C., Parks W. P., Rosemblum L. L., Kunstman K. J., Furtado M. R., Munoz J. L. Selective transmission of human immunodeficiency virus type-1 variants from mother to infants. Science. 255:1992;1134-1137.
23. Premack B. A., Schall T. J. Chemokine receptors: Gateways to inflammation and infection. Nature Med. 2:1996;1174-1178.
24. +. Science. 270:1996;1811-1813.
25. Patterson B. K., Landay A., Andersson J., Brown C., Behbahani H., Jiyamapa D., Burki Z., Stanislawski D., Czerniewski M. A., Garcia P. Repertoire of chemokine receptor expression in the female genital tract: Implications for HIV transmission. Am. J. Pathol. 153:1998;481-490.
26. Andersson, J. Fehniger, T. E. Patterson, B. K. Pottage, J. Agnoli, M. Jones, P. Behbahani, H. Landay, A. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy, AIDS, 12, F123, F129.
27. Liu R., Paxton W. A., Choe S., Ceradini D., Martin S. R., Horuk R., Macdonald M. E., Stuhlman H., Koup R. A., Landau N. R. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 86:1996;367-377.
28. Wu L., Paxton W. A., Kassam N., Ruffing N., Rottman J. B., Sullivan N., Choe H., Sodroski J., Newman W., Koup R. A., Mackay C. R. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 185:1997;1681-1691.
29. Zimmerman P. A., Buckler-White A., Alkhatib G., Spalding T., Kubofcik J., Combadiere C., Weissman D., Cohen O., Rubbert A., Lam G., Vaccarezza M., Kennedy P. E., Kumaraswami V., Giorgi J. V., Detels R., Hunter J., Chopek M., Berger E. A., Fauci A. S., Nutman T. B., Murphy P. M. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:1997;23-36.
30. Lacraz S., Nicod L. P., Chicheportiche R., Welgus H. G., Dayer J-M. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J. Clin. Invest. 96:1994;2304-2310.
31. Zagury D., Lachgar A., Chams V., Fall L. S., Bernard J., Zagury J. F., Bizzini B., Gringeri A., Santagostino E., Rappaport J., Feldman M., O'Brien S. J., Burny A., Gallo R. C. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc. Natl. Acad. Sci. USA. 95:1998;3857-3861.
32. Clerici M., Shearer G. M. The Th1-Th2 hypothesis of HIV infection: New insights. Immunol. Today. 15:1994;575-581.
33. Graziosi C., Pantaleo G., Gantt K. R., Fortin J-P., Demarest J. F., Cohen O. J., Sekaly R. P., Fauci A. S. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science. 265:1994;248-252.
34. Maggi E., Mazzeti M., Ravina A., Annunziato F., De Carli M., Piccinni M. P., Manetti R., Caronari M., Pesce A. M., Del Prete G., Romagnani S. Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science. 265:1994;244-248.
35. Clerici M., Sarin A., Coffman R. L., Wynn T. A., Blatt S. P., Hendrix C. W., Wolf S. F., Shearer G. M., Henkart P. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc. Natl. Acad. Sci. USA. 91:1994;11811-11815.