-
1
-
-
35948948662
-
Sepsis: Definition, epidemiology, and diagnosis
-
Lever A, Mackenzie I. Sepsis: definition, epidemiology, and diagnosis. BMJ 2007; 335: 879-83.
-
(2007)
BMJ
, vol.335
, pp. 879-883
-
-
Lever, A.1
Mackenzie, I.2
-
2
-
-
0034924156
-
Epidemiology of sepsis: An update
-
Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001; 29: 109-16.
-
(2001)
Crit Care Med
, vol.29
, pp. 109-116
-
-
Angus, D.C.1
Wax, R.S.2
-
3
-
-
33947527545
-
Evidence-based sepsis therapy: A hospitalist perspective
-
Jenkins I. Evidence-based sepsis therapy: a hospitalist perspective. J Hosp Med 2006; 1: 285-95.
-
(2006)
J Hosp Med
, vol.1
, pp. 285-295
-
-
Jenkins, I.1
-
5
-
-
17844410112
-
Novel therapies for sepsis: A review
-
Apr;
-
Deans KJ, Haley M, Natanson C, Eichacker PQ, Minneci PC. Novel therapies for sepsis: a review. J Trauma 2005 Apr; 58(4): 867-74.
-
(2005)
J Trauma
, vol.58
, Issue.4
, pp. 867-874
-
-
Deans, K.J.1
Haley, M.2
Natanson, C.3
Eichacker, P.Q.4
Minneci, P.C.5
-
6
-
-
0000155282
-
Suprarenal cortical hormone and salt in the treatment of pneumonia and other severe infections
-
Perla D, Marmorston J. Suprarenal cortical hormone and salt in the treatment of pneumonia and other severe infections. Endocrinology 1940; 27: 367-37.
-
(1940)
Endocrinology
, vol.27
, pp. 367-437
-
-
Perla, D.1
Marmorston, J.2
-
7
-
-
0342980285
-
A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin
-
Annane D, Sébille V, Troché G, Raphaël JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283: 1038-45.
-
(2000)
JAMA
, vol.283
, pp. 1038-1045
-
-
Annane, D.1
Sébille, V.2
Troché, G.3
Raphaël, J.C.4
Gajdos, P.5
Bellissant, E.6
-
8
-
-
0031722907
-
Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve
-
Annane D, Bellissant E, Sébille V, Lesieur O, Mathieu B, Raphaël JC et al. Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998; 46: 589-97.
-
(1998)
Br J Clin Pharmacol
, vol.46
, pp. 589-597
-
-
Annane, D.1
Bellissant, E.2
Sébille, V.3
Lesieur, O.4
Mathieu, B.5
Raphaël, J.C.6
-
10
-
-
0025672648
-
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells
-
Radomski MW, Palmer RM, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990; 87: 10043-7.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 10043-10047
-
-
Radomski, M.W.1
Palmer, R.M.2
Moncada, S.3
-
11
-
-
0027196668
-
Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man
-
Barber AE, Coyle SM, Marano MA, Fischer E, Calvano SE, Fong Y et al. Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 1993; 150: 1999-2006.
-
(1993)
J Immunol
, vol.150
, pp. 1999-2006
-
-
Barber, A.E.1
Coyle, S.M.2
Marano, M.A.3
Fischer, E.4
Calvano, S.E.5
Fong, Y.6
-
12
-
-
2942738987
-
Corticosteroids for treating severe sepsis and septic shock
-
Review, CD002243
-
Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev 2004; (1): CD002243. Review.
-
(2004)
Cochrane Database Syst Rev
, Issue.1
-
-
Annane, D.1
Bellissant, E.2
Bollaert, P.E.3
Briegel, J.4
Keh, D.5
Kupfer, Y.6
-
13
-
-
3042858950
-
Meta-analysis: The effect of steroids on survival and shock during sepsis depends on the dose
-
Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 2004; 141: 47-56.
-
(2004)
Ann Intern Med
, vol.141
, pp. 47-56
-
-
Minneci, P.C.1
Deans, K.J.2
Banks, S.M.3
Eichacker, P.Q.4
Natanson, C.5
-
14
-
-
33746885525
-
Effects of single dose of dexamethasone on patients with systemic inflammatory response
-
Mar 2;
-
Cicarelli DD, Benseñor FE, Vieira JE. Effects of single dose of dexamethasone on patients with systemic inflammatory response. Sao Paulo Med J. 2006 Mar 2; 124(2): 90-5.
-
(2006)
Sao Paulo Med J
, vol.124
, Issue.2
, pp. 90-95
-
-
Cicarelli, D.D.1
Benseñor, F.E.2
Vieira, J.E.3
-
15
-
-
3042772996
-
Physicians should administer low-dose corticosteroids selectively to septic patients until an ongoing trial is completed
-
Jul 6;
-
Luce JM. Physicians should administer low-dose corticosteroids selectively to septic patients until an ongoing trial is completed. Ann Intern Med 2004 Jul 6; 141(1): 70-2.
-
(2004)
Ann Intern Med
, vol.141
, Issue.1
, pp. 70-72
-
-
Luce, J.M.1
-
16
-
-
0028024881
-
Release of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist after intravenous immunoglobulin administration in vivo
-
Oct 1;
-
Aukrust P, Frøland SS, Liabakk NB, Müller F, Nordøy I, Haug C et al. Release of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist after intravenous immunoglobulin administration in vivo. Blood 1994 Oct 1; 84(7): 2136-43.
-
(1994)
Blood
, vol.84
, Issue.7
, pp. 2136-2143
-
-
Aukrust, P.1
Frøland, S.S.2
Liabakk, N.B.3
Müller, F.4
Nordøy, I.5
Haug, C.6
-
17
-
-
0019423632
-
Pepsin-treated human gamma globulin in bacterial infections. A randomized study in patients with septicaemia and pneumonia
-
May;
-
Lindquist L, Lundbergh P, Maasing R. Pepsin-treated human gamma globulin in bacterial infections. A randomized study in patients with septicaemia and pneumonia. Vox Sang 1981 May; 40(5): 329-37.
-
(1981)
Vox Sang
, vol.40
, Issue.5
, pp. 329-337
-
-
Lindquist, L.1
Lundbergh, P.2
Maasing, R.3
-
18
-
-
0019155436
-
Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients
-
Dec 13;
-
Jones RJ, Roe EA, Gupta JL. Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients. Lancet 1980 Dec 13; 2(8207): 1263-5.
-
(1980)
Lancet
, vol.2
, Issue.8207
, pp. 1263-1265
-
-
Jones, R.J.1
Roe, E.A.2
Gupta, J.L.3
-
20
-
-
3042790839
-
Polyclonal immunoglobulin for treatment of bacterial sepsis: A systematic review
-
Pildal J, Gotzsche PC. Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review. Clin Infect Dis 2004; 39:38-46.
-
(2004)
Clin Infect Dis
, vol.39
, pp. 38-46
-
-
Pildal, J.1
Gotzsche, P.C.2
-
21
-
-
36448996190
-
Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis
-
Laupland K, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis. Crit Care Med 2007; 35: 2686-92.
-
(2007)
Crit Care Med
, vol.35
, pp. 2686-2692
-
-
Laupland, K.1
Kirkpatrick, A.W.2
Delaney, A.3
-
22
-
-
36448938357
-
Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock
-
Kreymann KG, de Heer G, Nierhaus A, Kluge S. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. Crit Care Med 2007; 35: 2677-85.
-
(2007)
Crit Care Med
, vol.35
, pp. 2677-2685
-
-
Kreymann, K.G.1
de Heer, G.2
Nierhaus, A.3
Kluge, S.4
-
23
-
-
36448971653
-
Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study
-
Werdan K, Pilz G, Bujdoso O, Fraunberger P, Neeser G, Schmieder RE et al. Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study. Crit Care Med 2007; 35: 2693-701.
-
(2007)
Crit Care Med
, vol.35
, pp. 2693-2701
-
-
Werdan, K.1
Pilz, G.2
Bujdoso, O.3
Fraunberger, P.4
Neeser, G.5
Schmieder, R.E.6
-
24
-
-
8444244831
-
Recombinant human activated protein C in the treatment of severe sepsis: An evidence-based review
-
Fourrier F. Recombinant human activated protein C in the treatment of severe sepsis: an evidence-based review. Crit Care Med 2004; 32[Suppl.]: S534-S541.
-
(2004)
Crit Care Med
, vol.32
, Issue.SUPPL.
-
-
Fourrier, F.1
-
25
-
-
0037318946
-
Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis
-
Opal SM, Esmon CT. Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. Crit Care 2003; 7: 23-38.
-
(2003)
Crit Care
, vol.7
, pp. 23-38
-
-
Opal, S.M.1
Esmon, C.T.2
-
26
-
-
0029876674
-
Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome
-
Gando S, Kameue T, Nanzaki S, Nakanishi Y. Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome. Thromb Haemost 1996; 75: 224-8.
-
(1996)
Thromb Haemost
, vol.75
, pp. 224-228
-
-
Gando, S.1
Kameue, T.2
Nanzaki, S.3
Nakanishi, Y.4
-
27
-
-
0033554267
-
Variation in plasminogen activator-inhibitor-1 gene and risk of meningococcal septic shock
-
Westendorp RG, Hottenga JJ, Slagboom PE. Variation in plasminogen activator-inhibitor-1 gene and risk of meningococcal septic shock. Lancet 1999; 354: 561-3.
-
(1999)
Lancet
, vol.354
, pp. 561-563
-
-
Westendorp, R.G.1
Hottenga, J.J.2
Slagboom, P.E.3
-
28
-
-
0027311245
-
The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells
-
Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993; 268: 10739-45.
-
(1993)
J Biol Chem
, vol.268
, pp. 10739-10745
-
-
Dawson, S.J.1
Wiman, B.2
Hamsten, A.3
Green, F.4
Humphries, S.5
Henney, A.M.6
-
29
-
-
0037031812
-
-
Chavakis T, Pixley RA, Isordia-Salas I, Colman RW, Preissner KT. J Biol Chem 2002 Sep 6; 277(36): 32677-82. Epub 2002 Jun 24.
-
Chavakis T, Pixley RA, Isordia-Salas I, Colman RW, Preissner KT. J Biol Chem 2002 Sep 6; 277(36): 32677-82. Epub 2002 Jun 24.
-
-
-
-
30
-
-
27744581895
-
Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice
-
Renckens R, Roelofs JJTH, Horst SAJ, Veer CVT, Havik SV, Florquin S et al. Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice. J Immunol, 2005; 175: 6764-71.
-
(2005)
J Immunol
, vol.175
, pp. 6764-6771
-
-
Renckens, R.1
Roelofs, J.J.T.H.2
Horst, S.A.J.3
Veer, C.V.T.4
Havik, S.V.5
Florquin, S.6
-
31
-
-
33744804249
-
TAFI and PAI-1 levels in human sepsis
-
Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res 2006; 118: 205-12.
-
(2006)
Thromb Res
, vol.118
, pp. 205-212
-
-
Zeerleder, S.1
Schroeder, V.2
Hack, C.E.3
Kohler, H.P.4
Wuillemin, W.A.5
-
32
-
-
35748975414
-
Plasma thrombin activatable fibrinolysis inhibitor and tissue factor pathway inhibitor changes following sepsis
-
Oct;
-
Ravindranath TM, Goto M, Iqbal O, Florian-Kujawski M, Hoppensteadt D, Hammadeh R et al. Plasma thrombin activatable fibrinolysis inhibitor and tissue factor pathway inhibitor changes following sepsis. Clin Appl Thromb Hemost 2007 Oct; 13(4): 362-8.
-
(2007)
Clin Appl Thromb Hemost
, vol.13
, Issue.4
, pp. 362-368
-
-
Ravindranath, T.M.1
Goto, M.2
Iqbal, O.3
Florian-Kujawski, M.4
Hoppensteadt, D.5
Hammadeh, R.6
-
33
-
-
0038690407
-
-
Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis. A randomized controlled trial. JAMA. 2003 Jul 9; 290(2): 238-47. OPTIMIST Trial Study Group.
-
Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis. A randomized controlled trial. JAMA. 2003 Jul 9; 290(2): 238-47. OPTIMIST Trial Study Group.
-
-
-
-
34
-
-
21244438366
-
Tissue factor pathway inhibitor and antithrombin trial results
-
LaRosa SP, Opal SM. Tissue factor pathway inhibitor and antithrombin trial results. Crit Care Clin 2005; 21: 433-48.
-
(2005)
Crit Care Clin
, vol.21
, pp. 433-448
-
-
LaRosa, S.P.1
Opal, S.M.2
-
35
-
-
0031881384
-
Clinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure
-
Eisele B, Lamy M. Clinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure. Semin Thromb Hemost 1998, 24: 71-80.
-
(1998)
Semin Thromb Hemost
, vol.24
, pp. 71-80
-
-
Eisele, B.1
Lamy, M.2
-
36
-
-
0023227857
-
Heparin promotes the inactivation of antithrombin by elastase
-
Jordan RE, Kilpatrick J, Nelson RM. Heparin promotes the inactivation of antithrombin by elastase. Science 1987; 237: 777-9.
-
(1987)
Science
, vol.237
, pp. 777-779
-
-
Jordan, R.E.1
Kilpatrick, J.2
Nelson, R.M.3
-
37
-
-
9844239909
-
Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons
-
Niessen RW, Lamping RJ, Jansen PM, Prins MH, Peters M, Taylor FB et al. Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons. Thromb Haemost 1997; 78: 1088-92.
-
(1997)
Thromb Haemost
, vol.78
, pp. 1088-1092
-
-
Niessen, R.W.1
Lamping, R.J.2
Jansen, P.M.3
Prins, M.H.4
Peters, M.5
Taylor, F.B.6
-
38
-
-
56849105776
-
Antithrombin reduces expression of IL-6 and TF, inhibits activation of the transcription factor NF- in lipopolysaccharide stimulated monocytes and endothelial cells. Specific deactivation of monocyte and lymphocyte migration by ATIII concentrate
-
Reinisch C, Kaneider N, Rabensteiner A, Dunzendorfer B, Röuisch J, Weidermann CJ. Antithrombin reduces expression of IL-6 and TF, inhibits activation of the transcription factor NF- in lipopolysaccharide stimulated monocytes and endothelial cells. Specific deactivation of monocyte and lymphocyte migration by ATIII concentrate. Intensive Care Med 2000; 26: S302, A341.
-
(2000)
Intensive Care Med
, vol.26
, Issue.S302
-
-
Reinisch, C.1
Kaneider, N.2
Rabensteiner, A.3
Dunzendorfer, B.4
Röuisch, J.5
Weidermann, C.J.6
-
39
-
-
0033859376
-
Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway
-
Hoffmann JN, Vollmar B, Inthorn D, Schildberg FW, Menger MD. Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway. Am J Cell Physiol 2000; 279: C98-C107.
-
(2000)
Am J Cell Physiol
, vol.279
-
-
Hoffmann, J.N.1
Vollmar, B.2
Inthorn, D.3
Schildberg, F.W.4
Menger, M.D.5
-
40
-
-
0023757465
-
Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons
-
Taylor FB, Emerson TE, Jordan R, Chang AK, Blick KE. Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons. Circ Shock 1988; 26: 227-35.
-
(1988)
Circ Shock
, vol.26
, pp. 227-235
-
-
Taylor, F.B.1
Emerson, T.E.2
Jordan, R.3
Chang, A.K.4
Blick, K.E.5
-
41
-
-
0036333007
-
Quality of life effects of AT III in sepsis survivors: Results from the Kybersept trial
-
Rublee D, Opal SM, Schramm W, Keinecke H-O, Knaub S. Quality of life effects of AT III in sepsis survivors: results from the Kybersept trial. Crit Care 2002; 6: 249-56.
-
(2002)
Crit Care
, vol.6
, pp. 249-256
-
-
Rublee, D.1
Opal, S.M.2
Schramm, W.3
Keinecke, H.-O.4
Knaub, S.5
-
42
-
-
31344451275
-
High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety
-
Wiedermann CJ, Hoffmann JN, Juers M, Ostermann H, Kienast J, Briegel J. High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety. Crit Care Med 2006; 34: 285-92.
-
(2006)
Crit Care Med
, vol.34
, pp. 285-292
-
-
Wiedermann, C.J.1
Hoffmann, J.N.2
Juers, M.3
Ostermann, H.4
Kienast, J.5
Briegel, J.6
-
43
-
-
0024558370
-
The roles of protein C and thrombomodulin in the regulation of blood coagulation
-
Mar 25;
-
Esmon CTJ. The roles of protein C and thrombomodulin in the regulation of blood coagulation. Biol Chem 1989 Mar 25; 264(9): 4743-6.
-
(1989)
Biol Chem
, vol.264
, Issue.9
, pp. 4743-4746
-
-
Esmon, C.T.J.1
-
44
-
-
0029793068
-
The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
-
Bajzar L, Nesheim M, Tracy PB. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 1996; 88: 2093-100.
-
(1996)
Blood
, vol.88
, pp. 2093-2100
-
-
Bajzar, L.1
Nesheim, M.2
Tracy, P.B.3
-
45
-
-
33746086050
-
Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis
-
Jul;
-
Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski KB. Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis. Arch Surg 2006 Jul; 141(7): 670-6.
-
(2006)
Arch Surg
, vol.141
, Issue.7
, pp. 670-676
-
-
Alsfasser, G.1
Warshaw, A.L.2
Thayer, S.P.3
Antoniu, B.4
Laposata, M.5
Lewandrowski, K.B.6
-
46
-
-
0035815747
-
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
-
Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-203.
-
(2001)
J Biol Chem
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
Gelbert, L.2
Ciaccia, A.3
DeHoff, B.4
Grinnell, B.W.5
-
47
-
-
0033810792
-
Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
-
Fisher CJ, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med 2000; 28: S49-S56.
-
(2000)
Crit Care Med
, vol.28
-
-
Fisher, C.J.1
Yan, S.B.2
-
48
-
-
79960971566
-
Patients with severe sepsis vary markedly in their ability to generate activated protein C
-
Liaw PCY, Ferrell GL, Loeb M, Foley R, Weitz JI, Esmon CT. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 2001; 98: 445a.
-
(2001)
Blood
, vol.98
-
-
Liaw, P.C.Y.1
Ferrell, G.L.2
Loeb, M.3
Foley, R.4
Weitz, J.I.5
Esmon, C.T.6
-
49
-
-
0035826096
-
Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A et al.; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
LaRosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
-
50
-
-
0037389471
-
Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
-
Bernard GR, Macias WL, Joyce DE, Williams MD, Bailey J, Vincent JL. Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care 2003; 7(2): 155-63.
-
(2003)
Crit Care
, vol.7
, Issue.2
, pp. 155-163
-
-
Bernard, G.R.1
Macias, W.L.2
Joyce, D.E.3
Williams, M.D.4
Bailey, J.5
Vincent, J.L.6
-
51
-
-
2542638533
-
Activated protein C in sepsis: Emerging insights regarding its mechanism of action and clinical effectiveness
-
Review, Jun;
-
Haley M, Cui X, Minneci PC, Deans KJ, Natanson C, Eichacker PQ. Activated protein C in sepsis: emerging insights regarding its mechanism of action and clinical effectiveness. Curr Opin Infect Dis 2004 Jun; 17(3): 205-11. Review.
-
(2004)
Curr Opin Infect Dis
, vol.17
, Issue.3
, pp. 205-211
-
-
Haley, M.1
Cui, X.2
Minneci, P.C.3
Deans, K.J.4
Natanson, C.5
Eichacker, P.Q.6
-
52
-
-
25444492831
-
Administration of Drotrecogin Alfa (activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
-
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL et al.; Administration of Drotrecogin Alfa (activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005; 353: 1332-41.
-
(2005)
N Engl J Med
, vol.353
, pp. 1332-1341
-
-
Abraham, E.1
Laterre, P.F.2
Garg, R.3
Levy, H.4
Talwar, D.5
Trzaskoma, B.L.6
-
53
-
-
34249291301
-
-
Laterre PF, Abraham E, Janes JM, Trzaskoma BL, Correll NL, Booth FV. ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: One-year safety and efficacy evaluation.Crit Care Med 2007; 35: 1457-63.
-
Laterre PF, Abraham E, Janes JM, Trzaskoma BL, Correll NL, Booth FV. ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: One-year safety and efficacy evaluation.Crit Care Med 2007; 35: 1457-63.
-
-
-
-
55
-
-
33747637759
-
Activated protein C (Xigris©) treatment in sepsis: A drug in trouble
-
Sep;
-
Garlund B. Activated protein C (Xigris©) treatment in sepsis: a drug in trouble. Acta Anaesthesiol Scand 2006 Sep; 50(8): 907-10.
-
(2006)
Acta Anaesthesiol Scand
, vol.50
, Issue.8
, pp. 907-910
-
-
Garlund, B.1
-
56
-
-
14344255881
-
Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65
-
Mar;
-
Han Y, Englert JA, Yang R, Delude RL, Fink MP. Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther 2005 Mar; 312(3): 1097-105.
-
(2005)
J Pharmacol Exp Ther
, vol.312
, Issue.3
, pp. 1097-1105
-
-
Han, Y.1
Englert, J.A.2
Yang, R.3
Delude, R.L.4
Fink, M.P.5
-
57
-
-
27544456819
-
The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit antiinflammatory properties in vivo and/or in vitro
-
Nov 25;
-
Sappington PL, Cruz RJ Jr, Harada T, Yang R, Han Y, Englert JA et al. The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit antiinflammatory properties in vivo and/or in vitro. Biochem Pharmacol 2005 Nov 25; 70(11): 1579-92.
-
(2005)
Biochem Pharmacol
, vol.70
, Issue.11
, pp. 1579-1592
-
-
Sappington, P.L.1
Cruz Jr, R.J.2
Harada, T.3
Yang, R.4
Han, Y.5
Englert, J.A.6
-
58
-
-
0037616308
-
Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide induced shock
-
Venkataraman R, Kellum JA, Song M, Fink MP. Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide induced shock. Shock 2002; 18(6): 507-12.
-
(2002)
Shock
, vol.18
, Issue.6
, pp. 507-512
-
-
Venkataraman, R.1
Kellum, J.A.2
Song, M.3
Fink, M.P.4
-
59
-
-
0037125985
-
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
-
Sep 17;
-
Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002 Sep 17; 99(19): 12351-6.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.19
, pp. 12351-12356
-
-
Ulloa, L.1
Ochani, M.2
Yang, H.3
Tanovic, M.4
Halperin, D.5
Yang, R.6
-
60
-
-
1842588303
-
Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes
-
Review
-
Wagman AS, Johnson KW, Bussiere DE. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr Pharm Des 2004; 10(10): 1105-37. Review.
-
(2004)
Curr Pharm Des
, vol.10
, Issue.10
, pp. 1105-1137
-
-
Wagman, A.S.1
Johnson, K.W.2
Bussiere, D.E.3
-
61
-
-
0034612636
-
Requirement for glycogen synthase kinase-3b in cell survival and NF-kB activation
-
Jul 6;
-
Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3b in cell survival and NF-kB activation. Nature 2000 Jul 6; 406(6791): 86-90.
-
(2000)
Nature
, vol.406
, Issue.6791
, pp. 86-90
-
-
Hoeflich, K.P.1
Luo, J.2
Rubie, E.A.3
Tsao, M.S.4
Jin, O.5
Woodgett, J.R.6
-
62
-
-
23944509740
-
GSK-3b inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone treated myotubes
-
Oct;
-
Evenson AR, Fareed MU, Menconi MJ, Mitchell JC, Hasselgren PO. GSK-3b inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone treated myotubes. Int J Biochem Cell Biol 2005 Oct; 37(10): 2226-38.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, Issue.10
, pp. 2226-2238
-
-
Evenson, A.R.1
Fareed, M.U.2
Menconi, M.J.3
Mitchell, J.C.4
Hasselgren, P.O.5
-
63
-
-
9144236957
-
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia
-
Nov 12;
-
Bi X, Baudry M, Liu J, Yao Y, Fu L, Brucher F et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. J Biol Chem 2004 Nov 12; 279(46): 48238-45.
-
(2004)
J Biol Chem
, vol.279
, Issue.46
, pp. 48238-48245
-
-
Bi, X.1
Baudry, M.2
Liu, J.3
Yao, Y.4
Fu, L.5
Brucher, F.6
-
64
-
-
0037233913
-
HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
-
Jan 1;
-
Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MP et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003 Jan 1; 23(1): 58-63.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, Issue.1
, pp. 58-63
-
-
Dichtl, W.1
Dulak, J.2
Frick, M.3
Alber, H.F.4
Schwarzacher, S.P.5
Ares, M.P.6
-
65
-
-
0030838319
-
HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
-
Nov 1;
-
Weber C, Erl W, Weber KS, Weber PC. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 1997 Nov 1; 30(5): 1212-7.
-
(1997)
J Am Coll Cardiol
, vol.30
, Issue.5
, pp. 1212-1217
-
-
Weber, C.1
Erl, W.2
Weber, K.S.3
Weber, P.C.4
-
66
-
-
0035723275
-
Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism
-
Jul;
-
Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA Jr et al. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 2001 Jul; 21(7): 1165-71.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, Issue.7
, pp. 1165-1171
-
-
Yoshida, M.1
Sawada, T.2
Ishii, H.3
Gerszten, R.E.4
Rosenzweig, A.5
Gimbrone Jr, M.A.6
-
67
-
-
0033543673
-
Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain
-
Sep 10;
-
Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol 1999 Sep 10; 292(1): 1-9.
-
(1999)
J Mol Biol
, vol.292
, Issue.1
, pp. 1-9
-
-
Kallen, J.1
Welzenbach, K.2
Ramage, P.3
Geyl, D.4
Kriwacki, R.5
Legge, G.6
-
68
-
-
2642553075
-
HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis
-
Jun 1;
-
Merx MW, Liehn EA, Janssens U, Lütticken R, Schrader J, Hanrath P et al. HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 2004 Jun 1; 109(21): 2560-5.
-
(2004)
Circulation
, vol.109
, Issue.21
, pp. 2560-2565
-
-
Merx, M.W.1
Liehn, E.A.2
Janssens, U.3
Lütticken, R.4
Schrader, J.5
Hanrath, P.6
-
69
-
-
20244378532
-
Simvastatin blunts endotoxin-induced tissue factor in vivo
-
Steiner S, Speidl WS, Pleiner J, Seidinger D, Zorn G, Kaun C et al. Simvastatin blunts endotoxin-induced tissue factor in vivo. Circulation 2005; 111: 1841-6.
-
(2005)
Circulation
, vol.111
, pp. 1841-1846
-
-
Steiner, S.1
Speidl, W.S.2
Pleiner, J.3
Seidinger, D.4
Zorn, G.5
Kaun, C.6
-
70
-
-
33750360916
-
Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo
-
Dec;
-
Niessner A, Steiner S, Speidl WS, Pleiner J, Seidinger D, Maurer G et al. Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo. Atherosclerosis 2006 Dec; 189(2): 408-13.
-
(2006)
Atherosclerosis
, vol.189
, Issue.2
, pp. 408-413
-
-
Niessner, A.1
Steiner, S.2
Speidl, W.S.3
Pleiner, J.4
Seidinger, D.5
Maurer, G.6
-
71
-
-
4143083577
-
Prior statin therapy is associated with a decreased rate of severe sepsis
-
Aug 17;
-
Almog Y, Shefer A, Novack V, Maimon N, Barski L, Eizinger M et al. Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 2004 Aug 17; 110(7): 880-5.
-
(2004)
Circulation
, vol.110
, Issue.7
, pp. 880-885
-
-
Almog, Y.1
Shefer, A.2
Novack, V.3
Maimon, N.4
Barski, L.5
Eizinger, M.6
-
72
-
-
33645826944
-
Statin use and mortality within 180 days after bacteremia: A population-based cohort study
-
Apr;
-
Thomsen RW, Hundborg HH, Johnsen SP, Pedersen L, Sørensen HT, Schønheyder HC et al. Statin use and mortality within 180 days after bacteremia: a population-based cohort study. Crit Care Med 2006 Apr; 34(4): 1080-6.
-
(2006)
Crit Care Med
, vol.34
, Issue.4
, pp. 1080-1086
-
-
Thomsen, R.W.1
Hundborg, H.H.2
Johnsen, S.P.3
Pedersen, L.4
Sørensen, H.T.5
Schønheyder, H.C.6
-
73
-
-
29844438975
-
Statin therapy prior to ICU admission: Protection against infection or a severity marker?
-
Jan;
-
Fernandez R, De Pedro VJ, Artigas A. Statin therapy prior to ICU admission: protection against infection or a severity marker? Intensive Care Med 2006 Jan; 32(1): 160-4.
-
(2006)
Intensive Care Med
, vol.32
, Issue.1
, pp. 160-164
-
-
Fernandez, R.1
De Pedro, V.J.2
Artigas, A.3
-
74
-
-
31844434994
-
Statins and sepsis in patients with cardiovascular disease: A population-based cohort analysis
-
Feb 4;
-
Hackam DG, Mamdani M, Li P, Redelmeier DA. Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet 2006 Feb 4; 367(9508): 413-8.
-
(2006)
Lancet
, vol.367
, Issue.9508
, pp. 413-418
-
-
Hackam, D.G.1
Mamdani, M.2
Li, P.3
Redelmeier, D.A.4
-
76
-
-
33746028777
-
Intracellular pattern recognition receptors in the host response
-
Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006; 442: 39-44.
-
(2006)
Nature
, vol.442
, pp. 39-44
-
-
Meylan, E.1
Tschopp, J.2
Karin, M.3
-
77
-
-
23744454577
-
TLR signalling and activation of IRFs: Revisiting old friends from the NF- B pathway
-
Moynagh PN. TLR signalling and activation of IRFs: revisiting old friends from the NF- B pathway. Trends Immunol 2005; 26: 469-76.
-
(2005)
Trends Immunol
, vol.26
, pp. 469-476
-
-
Moynagh, P.N.1
-
78
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
79
-
-
34249677845
-
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
-
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13: 552-9.
-
(2007)
Nat Med
, vol.13
, pp. 552-559
-
-
Kanzler, H.1
Barrat, F.J.2
Hessel, E.M.3
Coffman, R.L.4
-
80
-
-
3142713223
-
Inhibition of endotoxin response by synthetic TLR4 antagonists
-
Hawkins LD, Christ WJ, Rossignol DP. Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem 2004; 4: 1147-71.
-
(2004)
Curr Top Med Chem
, vol.4
, pp. 1147-1171
-
-
Hawkins, L.D.1
Christ, W.J.2
Rossignol, D.P.3
-
81
-
-
0037372661
-
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
-
Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S et al. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 2003; 304: 1093-102.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1093-1102
-
-
Mullarkey, M.1
Rose, J.R.2
Bristol, J.3
Kawata, T.4
Kimura, A.5
Kobayashi, S.6
-
82
-
-
0037442501
-
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
-
Lynn M, Rossignol DP, Wheeler JL, Kao RJ, Perdomo CA, Noveck R et al. Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J Infect Dis 2003; 187: 631-9.
-
(2003)
J Infect Dis
, vol.187
, pp. 631-639
-
-
Lynn, M.1
Rossignol, D.P.2
Wheeler, J.L.3
Kao, R.J.4
Perdomo, C.A.5
Noveck, R.6
|