Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: A prospective pilot study

Pediatric Pulmonology

Volumn 43, Issue 12, 2008, Pages 1161-1166

  Richir, Milan C ^a   Van Leeuwen, Paul A M ^a   Van Den Berg, Anemone ^a   Wessels, Ronni ^a   Twisk, Jos W R ^a   Rauwerda, Jan A ^a   Teerlink, Tom ^a   De Vries, Theo P G M ^a   Van Elburg, Ruurd M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ADMA; Asymmetric dimethylarginine; Mechanical ventilation; Preterm infant

Indexed keywords

ARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ARTICLE; ARTIFICIAL VENTILATION; BIRTH WEIGHT; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GAS EXCHANGE; GESTATIONAL AGE; HUMAN; INFANT; MALE; PILOT STUDY; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; UMBILICAL CORD BLOOD;

ARGININE; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; MALE; NITRIC OXIDE SYNTHASE; PILOT PROJECTS; PREMATURE BIRTH; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN; TIME FACTORS;

EID: 56849093442     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.20886     Document Type: Article

References (39)

1. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994;149:538-551.
2. Kawai N, Bloch DB, Filippov G, Rabkina D, Suen HC, Losty PD, Janssens SP, Zapol WM, de la MS, Bloch KD. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol 1995;268:L589-L595.
3. Barnes PJ. Nitric oxide and airway disease. Ann Med 1995;27:389-393.
4. Forstermann U, Schmidt HH, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol 1991;42:1849-1857.
5. Dweik RA. The lung in the balance: arginine, methylated arginines, and nitric oxide. Am J Physiol Lung Cell Mol Physiol 2007;292:L15-L17.
6. Kang JL, Park W, Pack IS, Lee HS, Kim MJ, Lim CM, Koh Y. Inhaled nitric oxide attenuates acute lung injury via inhibition of nuclear factor-kappa B and inflammation. J Appl Physiol 2002;92:795-801.
7. Ballard PL, Gonzales LW, Godinez RI, Godinez MH, Savani RC, McCurnin DC, Gibson LL, Yoder BA, Kerecman JD, Grubb PH, Shaul PW. Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide. Pediatr Res 2006;59:157-162.
8. Cotton RB, Sundell HW, Zeldin DC, Morrow JD, Roberts LJ, Hazinski TA, Law AB, Steele S. Inhaled nitric oxide attenuates hyperoxic lung injury in lambs. Pediatr Res 2006;59:142-146.
9. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA, Kerecman JD, Albertine KH, Winter VT, Coalson JJ, Crapo JD, Grubb PH, Shaul PW. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol 2005;288:L450-L459.
10. Tang JR, Markham NE, Lin YJ, McMurtry IF, Maxey A, Kinsella JP, Abman SH. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 2004;287:L344-L351.
11. Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med 2003;349:2099-2107.
12. Kinsella JP. Inhaled nitric oxide therapy in premature newborns. Curr Opin Pediatr 2006;18:107-111.
13. Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, Cutter GR, Baier M, Abman SH. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 1999;354:1061-1065.
14. Banks BA, Seri I, Ischiropoulos H, Merrill J, Rychik J, Ballard RA. Changes in oxygenation with inhaled nitric oxide in severe bronchopulmonary dysplasia. Pediatrics 1999;103:610-618.
15. Clark PL, Ekekezie II, Kaftan HA, Castor CA, Truog WE. Safety and efficacy of nitric oxide in chronic lung disease. Arch Dis Child Fetal Neonatal Ed 2002;86:F41-F45.
16. Subhedar N, Dewhurst C. Is nitric oxide effective in preterm infants? Arch Dis Child Fetal Neonatal Ed 2007;92:F337-F341.
17. Barrington K, Finer N. Inhaled nitric oxide respiratory failure in preterm infants. Cochrane Database Syst Rev 2007;3: CD000509.
18. Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004;24:1023-1030.
19. Teerlink T. ADMA metabolism and clearance. Vasc Med 2005;10:S73-S81.
20. Siroen MP, Teerlink T, Bolte AC, van Elburg RM, Richir MC, Nijveldt RJ, van der Hoven B, van Leeuwen PA. No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia. Gynecol Obstet Invest 2006;62:7-13.
21. Maeda T, Yoshimura T, Okamura H. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation. J Soc Gynecol Investig 2003;10:2-4.
22. Vida G, Sulyok E, Ertl T, Martens-Lobenhoffer J, Bode-Boger SM. Plasma asymmetric dimethylarginine concentration during the perinatal period. Neonatology 2007;92:8-13.
23. Mittermayer F, Prusa AR, Pollak A, Wolzt M. Umbilical vein plasma concentrations of asymmetrical dimethylarginine are increased in male but not female neonates delivered preterm: a pilot study. Early Hum Dev 2005;82:421-424.
24. Tsukahara H, Ohta N, Tokuriki S, Nishijima K, Kotsuji F, Kawakami H, Ohta N, Sekine K, Nagasaka H, Mayumi M. Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood. Metabolism 2008;57:215-220.
25. Usher R, Mclean F. Intrauterine growth of live-born caucasian infants at sea level - standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. J Pediatr 1969;74:901-910.
26. De Jong S, Teerlink T. Analysis of asymmetric dimethylarginine in plasma by HPLC using a monolithic column. Anal Biochem 2006;353:287-289.
27. Lucke T, Kanzelmeyer N, Kemper MJ, Tsikas D, Das AM. Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. Clin Chem Lab Med 2007;45:1525-1530.
28. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999;99:3092-3095.
29. Arrigoni FI, Vallance P, Haworth SG, Leiper JM. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation 2003;107:1195-1201.
30. Leiper JM, Santa MJ, Chubb A, MacAllister RJ, Charles IG, Whitley GS, Vallance P. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J 1999;343:209-214.
31. Vallance P, Leone A, Calver A, Collier J, Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 1992;20:S60-S62.
32. Bulau P, Zakrzewicz D, Kitowska K, Leiper J, Gunther A, Grimminger F, Eickelberg O. Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am J Physiol Lung Cell Mol Physiol 2007;292:L18-L24.
33. Dweik RA, Laskowski D, Abu-Soud HM, Kaneko F, Hutte R, Stuehr DJ, Erzurum SC. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. J Clin Invest 1998;101:660-666.
34. Shaul PW, Afshar S, Gibson LL, Sherman TS, Kerecman JD, Grubb PH, Yoder BA, McCurnin DC. Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung. Am J Physiol Lung Cell Mol Physiol 2002;283:L1192-L1199.
35. Halbower AC, Tuder RM, Franklin WA, Pollock JS, Forstermann U, Abman SH. Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung. Am J Physiol 1994;267:L585-L591.
36. Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ. Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia? Circ Res 2004;94:1115-1123.
37. Heckmann M, Kreuder J, Riechers K, Tsikas D, Boedeker RH, Reiss I, Gortner L. Plasma arginine and urinary nitrate and nitrite excretion in bronchopulmonary dysplasia. Biol Neonate 2004;85:173-178.
38. Baylis C, Vallance P. Measurement of nitrite and nitrate levels in plasma and urine-what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens 1998;7:59-62.
39. Farkouh CR, Merrill JD, Ballard PL, Ballard RA, Ischiropoulos H, Lorch SA. Urinary metabolites of oxidative stress and nitric oxide in preterm and term infants. Biol Neonate 2006;90:233-242.