Umbilical vein plasma concentrations of asymmetrical dimethylarginine are increased in male but not female neonates delivered preterm: A pilot study

Early Human Development

Volumn 82, Issue 7, 2006, Pages 421-424

  Mittermayer, Friedrich ^a   Prusa, Andrea Romana ^a   Pollak, Arnold ^a   Wolzt, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Asymmetrical dimethylarginine; Newborn; Preterm; Sex differences

Indexed keywords

ARGININE; ARGININE DERIVATIVE; N(G),N(G) DIMETHYLARGININE; SYMMETRICAL DIMETHYLARGININE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BODY WEIGHT; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FETUS CIRCULATION; GESTATION PERIOD; GESTATIONAL AGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NEWBORN; PERINATAL DEVELOPMENT; PREMATURE LABOR; PREMATURITY; SEX DIFFERENCE; SEX RATIO; STATISTICAL SIGNIFICANCE; UMBILICAL CORD BLOOD; UMBILICAL VEIN; VENOUS BLOOD;

ARGININE; BLOOD CIRCULATION; BODY WEIGHT; FEMALE; FETAL BLOOD; HUMANS; INFANT, NEWBORN; MALE; NITRIC OXIDE SYNTHASE; PILOT PROJECTS; PREMATURE BIRTH; SEX CHARACTERISTICS; TIME FACTORS;

EID: 33745507644     PISSN: 03783782     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.earlhumdev.2005.08.005     Document Type: Article

References (24)

1. Closs E.I., Basha F.Z., Habermeier A., and Forstermann U. Interference of l-arginine analogues with l-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide 1 (1997) 65-73
2. Leiper J., and Vallance P. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res 43 (1999) 542-548
3. Achan V., Broadhead M., Malaki M., Whitley G., Leiper J., MacAllister R., et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 23 (2003) 1455-1459
4. Böger R.H. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res 59 (2003) 824-833
5. Maeda T., Yoshimura T., and Okamura H. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation. J Soc Gynecol Investig 10 (2003) 2-4
6. Yoshimura T., Magness R.R., and Rosenfeld C.R. Angiotensin II and alpha-agonist: I. Responses of ovine fetoplacental vasculature. Am J Physiol 259 (1990) H464-H472
7. Yang D., Lang U., Greenberg S.G., Myatt L., and Clark K.E. Elevation of nitrate levels in pregnant ewes and their fetuses. Am J Obstet Gynecol 174 (1996) 573-577
8. Dzik J.M., Dobrzanska A., Gruszfeld D., and Walajtys-Rode E. Nitric oxide metabolites in the urine of full-term and preterm infants. Pediatr Int 44 (2002) 368-375
9. Tsukahara H., Takeuchi M., Hata I., Hiraoka M., Kotsuji F., Sudo M., et al. Assessment of endogenous nitric oxide formation in newborns: measurement of urinary nitrite and nitrate concentrations. Biol Neonate 72 (1997) 322-326
10. Mittermayer F., Namiranian K., Pleiner J., Schaller G., and Wolzt M. Acute E. coli endotoxemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans. Clin Sci (Lond) 106 (2004) 577-581
11. Sladek S.M., Magness R.R., and Conrad K.P. Nitric oxide and pregnancy. Am J Physiol 272 (1997) R441-R463
12. Williams D.J., Vallance P.J., Neild G.H., Spencer J.A., and Imms F.J. Nitric oxide-mediated vasodilation in human pregnancy. Am J Physiol 272 (1997) H748-H752
13. Mittermayer F., Namiranian K., Pleiner J., Schaller G., and Wolzt M. Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans. Clin Sci (Lond) 106 (2004) 577-581
14. Pawlak M.R., Scherer C.A., Chen J., Roshon M.J., and Ruley H.E. Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Mol Cell Biol 20 (2000) 4859-4869
15. MacAllister R.J., Parry H., Kimoto M., Ogawa T., Russell R.J., Hodson H., et al. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 119 (1996) 1533-1540
16. Vallance P., Leone A., Calver A., Collier J., and Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339 (1992) 572-575
17. Arrigoni F.I., Vallance P., Haworth S.G., and Leiper J.M. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation 107 (2003) 1195-1201
18. Bueva A., and Guignard J.P. Renal function in preterm neonates. Pediatr Res 36 (1994) 572-577
19. Guignard J.P., and Drukker A. Why do newborn infants have a high plasma creatinine?. Pediatrics 103 (1999) e49
20. Scott S.M., Guardian C.M., Angelus P., and Backstrom C. Developmental pattern of urinary epidermal growth factor in the premature infant and the influence of gender. J Clin Endocrinol Metab 72 (1991) 588-593
21. Ott W.J. Small for gestational age fetus and neonatal outcome: reevaluation of the relationship. Am J Perinatol 12 (1995) 396-400
22. Dusick A.M. Medical outcomes in preterm infants. Semin Perinatol 21 (1997) 164-177
23. Lal M.K., Manktelow B.N., Draper E.S., and Field D.J. Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study. Pediatrics 111 (2003) 483-487
24. Ingemarsson I. Gender aspects of preterm birth. BJOG 110 Suppl. 20 (2003) 34-38