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Volumn 18, Issue 2, 2006, Pages 107-111

Inhaled nitric oxide therapy in premature newborns

Author keywords

Bronchopulmonary dysplasia; Intraventricular hemorrhage; Nitric oxide; Prematurity; Respiratory distress syndrome

Indexed keywords

NITRIC OXIDE;

EID: 33646523863     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mop.0000193291.09894.6c     Document Type: Review
Times cited : (14)

References (41)
  • 1
    • 0034677445 scopus 로고    scopus 로고
    • Randomized, controlled trial of low-dose inhaled nitric oxide treatment of persistent pulmonary hypertension of the newborn
    • Clark RH, Kueser TJ, Walker MW, et al. Randomized, controlled trial of low-dose inhaled nitric oxide treatment of persistent pulmonary hypertension of the newborn. N Engl J Med 2000; 17; 342 (7):469-474.
    • (2000) N Engl J Med , vol.17-342 , Issue.7 , pp. 469-474
    • Clark, R.H.1    Kueser, T.J.2    Walker, M.W.3
  • 2
    • 0031052369 scopus 로고    scopus 로고
    • Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure
    • Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997; 336:597-604.
    • (1997) N Engl J Med , vol.336 , pp. 597-604
  • 3
    • 0014208018 scopus 로고
    • Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia
    • Northway WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967; 276:357-368.
    • (1967) N Engl J Med , vol.276 , pp. 357-368
    • Northway, W.H.1    Rosan, R.C.2    Porter, D.Y.3
  • 4
    • 0026611008 scopus 로고
    • Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn
    • Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340:819-820.
    • (1992) Lancet , vol.340 , pp. 819-820
    • Kinsella, J.P.1    Neish, S.R.2    Shaffer, E.3    Abman, S.H.4
  • 5
    • 0026731804 scopus 로고
    • Inhaled nitric oxide in persistent pulmonary hypertension of the newborn
    • Roberts JD, Polaner DM, Lang P, et al. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340:818-819.
    • (1992) Lancet , vol.340 , pp. 818-819
    • Roberts, J.D.1    Polaner, D.M.2    Lang, P.3
  • 6
    • 0027517933 scopus 로고
    • Inhaled nitric oxide in the management of a premature newborn with severe respiratory distress and pulmonary hypertension
    • Abman SH, Kinsella JP, Schaffer MS, Wilkening RB. Inhaled nitric oxide in the management of a premature newborn with severe respiratory distress and pulmonary hypertension. Pediatrics 1993; 92:606-609.
    • (1993) Pediatrics , vol.92 , pp. 606-609
    • Abman, S.H.1    Kinsella, J.P.2    Schaffer, M.S.3    Wilkening, R.B.4
  • 7
    • 0028045680 scopus 로고
    • Ontogeny of NO activity and response to inhaled NO in the developing ovine pulmonary circulation
    • Kinsella JP, Ivy DD, Abman SH. Ontogeny of NO activity and response to inhaled NO in the developing ovine pulmonary circulation. Am J Physiol 1994; 267:H1955-H1961.
    • (1994) Am J Physiol , vol.267
    • Kinsella, J.P.1    Ivy, D.D.2    Abman, S.H.3
  • 8
    • 0028070950 scopus 로고
    • Inhaled nitric oxide lowers pulmonary vascular resistance and improves gas exchange in severe experimental hyaline membrane disease
    • Kinsella JP, Ivy DD, Abman SH. Inhaled nitric oxide lowers pulmonary vascular resistance and improves gas exchange in severe experimental hyaline membrane disease. Pediatr Res 1994; 36:402-408.
    • (1994) Pediatr Res , vol.36 , pp. 402-408
    • Kinsella, J.P.1    Ivy, D.D.2    Abman, S.H.3
  • 9
    • 0028910754 scopus 로고
    • Nitric oxide is an antiadhesive molecule for leukocytes
    • Kanwar S, Kubes P. Nitric oxide is an antiadhesive molecule for leukocytes. N Horiz 1995; 3:93-104.
    • (1995) N Horiz , vol.3 , pp. 93-104
    • Kanwar, S.1    Kubes, P.2
  • 10
    • 0030928473 scopus 로고    scopus 로고
    • Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease
    • Kinsella JP, Parker TA, Galan H, et al. Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997; 41:457-463.
    • (1997) Pediatr Res , vol.41 , pp. 457-463
    • Kinsella, J.P.1    Parker, T.A.2    Galan, H.3
  • 11
    • 0020618621 scopus 로고
    • Elastase and α-1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome
    • Merritt TA, Cochrane CG, Holcomb K, et al. Elastase and α-1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. J Clin Invest 1983; 72:656-666.
    • (1983) J Clin Invest , vol.72 , pp. 656-666
    • Merritt, T.A.1    Cochrane, C.G.2    Holcomb, K.3
  • 12
    • 0020538790 scopus 로고
    • Lung lavage of newborns with respiratory distress syndrome: Prolonged neutrophil influx is associated with bronchopulmonary dysplasia
    • Ogden BE, Murphy S, Saunders GC, Johnson JD. Lung lavage of newborns with respiratory distress syndrome: prolonged neutrophil influx is associated with bronchopulmonary dysplasia. Chest 1983; 83:31-33.
    • (1983) Chest , vol.83 , pp. 31-33
    • Ogden, B.E.1    Murphy, S.2    Saunders, G.C.3    Johnson, J.D.4
  • 13
    • 0027410584 scopus 로고
    • Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome
    • Speer CP, Ruess D, Harms K, et al. Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome. Pediatrics 1993; 91:794-799.
    • (1993) Pediatrics , vol.91 , pp. 794-799
    • Speer, C.P.1    Ruess, D.2    Harms, K.3
  • 14
    • 0029953331 scopus 로고    scopus 로고
    • Leakage of protein into lungs of preterm ventilated rabbits is correlated with activation of clotting, complement, and polymorphonuclear leukocytes in plasma
    • Brus F, Van Oeveren W, Heikamp A, et al. Leakage of protein into lungs of preterm ventilated rabbits is correlated with activation of clotting, complement, and polymorphonuclear leukocytes in plasma. Pediatr Res 1996; 39:958-965.
    • (1996) Pediatr Res , vol.39 , pp. 958-965
    • Brus, F.1    Van Oeveren, W.2    Heikamp, A.3
  • 15
    • 0029003021 scopus 로고
    • Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia
    • Zimmerman JJ. Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia. Clin Perinatol 1995; 22:429-456.
    • (1995) Clin Perinatol , vol.22 , pp. 429-456
    • Zimmerman, J.J.1
  • 16
    • 6844250771 scopus 로고    scopus 로고
    • Inhaled nitric oxide neither alters oxidative stress parameters nor induces lung inflammation in premature lambs with moderate hyaline membrane disease
    • Storme L, Zerimech F, Riou Y, et al. Inhaled nitric oxide neither alters oxidative stress parameters nor induces lung inflammation in premature lambs with moderate hyaline membrane disease. Bio Neonatol 1998; 73:172-181.
    • (1998) Bio Neonatol , vol.73 , pp. 172-181
    • Storme, L.1    Zerimech, F.2    Riou, Y.3
  • 17
    • 0031777045 scopus 로고    scopus 로고
    • Nitric oxide increases the survival of rats with a high oxygen exposure
    • Nelin LD, Welty SE, Morrisey JF, et al. Nitric oxide increases the survival of rats with a high oxygen exposure. Pediatr Res 1998; 43:727-732.
    • (1998) Pediatr Res , vol.43 , pp. 727-732
    • Nelin, L.D.1    Welty, S.E.2    Morrisey, J.F.3
  • 18
    • 0029957727 scopus 로고    scopus 로고
    • Nitric oxide regulation of superoxide-dependent lung injury: Oxidant-protective actions of endogenously produced and exogenously administered nitric oxide
    • Gutierrez HH, Nieves B, Chumley P, et al. Nitric oxide regulation of superoxide-dependent lung injury: oxidant-protective actions of endogenously produced and exogenously administered nitric oxide. Free Radic Biol Med 1996; 21:43-52.
    • (1996) Free Radic Biol Med , vol.21 , pp. 43-52
    • Gutierrez, H.H.1    Nieves, B.2    Chumley, P.3
  • 19
    • 0032980714 scopus 로고    scopus 로고
    • Inhaled nitric oxide decreases hyperoxia-induced surfactant abnormality in preterm rabbits
    • Issa A, Lappalainen U, Kleinman M, et al. Inhaled nitric oxide decreases hyperoxia-induced surfactant abnormality in preterm rabbits. Pediatr Res 1999; 45:247-254.
    • (1999) Pediatr Res , vol.45 , pp. 247-254
    • Issa, A.1    Lappalainen, U.2    Kleinman, M.3
  • 20
    • 0034786027 scopus 로고    scopus 로고
    • Reduced endothelial nitric oxide synthase in lungs of chronically ventilated preterm lambs
    • MacRitchie AN, Albertine KH, Sun J, et al. Reduced endothelial nitric oxide synthase in lungs of chronically ventilated preterm lambs. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1011-L1020.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • MacRitchie, A.N.1    Albertine, K.H.2    Sun, J.3
  • 21
    • 0037405782 scopus 로고    scopus 로고
    • Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
    • Afshar S, Gibson LL, Yuhanna IS, et al. Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease. Am J Physiol Lung Cell Mol Physiol 2003; 284:L749-L758.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Afshar, S.1    Gibson, L.L.2    Yuhanna, I.S.3
  • 22
    • 3242660994 scopus 로고    scopus 로고
    • Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
    • Tang JR, Markham NE, Balasubramaniam V, et al. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 2004; 287:L344-L351.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Tang, J.R.1    Markham, N.E.2    Balasubramaniam, V.3
  • 23
    • 3242660994 scopus 로고    scopus 로고
    • Inhaled NO attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
    • Tang JR, Markham NE, Lin YJ, et al. Inhaled NO attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 2004; 287:L344-L351. Exposure of newborn rats to hyperoxia impairs alveolarization and vessel growth. In this study, newborn rats exposed to hyperoxia had reduced lung VEGF, VEGFR-2, and eNOS protein expression and decreased distal lung growth. Inhaled NO treatment restored distal lung growth.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Tang, J.R.1    Markham, N.E.2    Lin, Y.J.3
  • 24
    • 13644268445 scopus 로고    scopus 로고
    • Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
    • McCurnin DC, Pierce RA, Chang LY, et al. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung 2005; 288:450-459. Pulmonary NO production is decreased in a baboon model of chronic lung disease after premature birth. In this study, premature baboons were mechanically ventilated for 14 days and treated with 5 ppm INO. Inhaled NO improved early pulmonary function and altered extracellular matrix deposition compared to controls.
    • (2005) Am J Physiol Lung , vol.288 , pp. 450-459
    • McCurnin, D.C.1    Pierce, R.A.2    Chang, L.Y.3
  • 25
    • 0028932208 scopus 로고
    • Inhaled nitric oxide for premature infants after prolonged rupture of the membranes
    • Peliowski A, Finer NN, Etches PC, et al. Inhaled nitric oxide for premature infants after prolonged rupture of the membranes. J Pediatr 1995; 126:450-453.
    • (1995) J Pediatr , vol.126 , pp. 450-453
    • Peliowski, A.1    Finer, N.N.2    Etches, P.C.3
  • 26
    • 9844256446 scopus 로고    scopus 로고
    • Response of premature infants with severe respiratory failure to inhaled nitric oxide
    • Van Meurs KP, Rhine WD, Asselin JM, Durand DJ. Response of premature infants with severe respiratory failure to inhaled nitric oxide. Pediatr Pulmonol 1997; 24:319-323.
    • (1997) Pediatr Pulmonol , vol.24 , pp. 319-323
    • Van Meurs, K.P.1    Rhine, W.D.2    Asselin, J.M.3    Durand, D.J.4
  • 28
    • 0027267083 scopus 로고
    • Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor
    • Simon DI, Stamler JS, Jaraki O, et al. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb 1993; 13:791-799.
    • (1993) Arterioscler Thromb , vol.13 , pp. 791-799
    • Simon, D.I.1    Stamler, J.S.2    Jaraki, O.3
  • 29
    • 0031925241 scopus 로고    scopus 로고
    • The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates
    • George TN, Johnson KJ, Bates JN, Segar JL. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 1998; 132:731-734.
    • (1998) J Pediatr , vol.132 , pp. 731-734
    • George, T.N.1    Johnson, K.J.2    Bates, J.N.3    Segar, J.L.4
  • 30
    • 0031411595 scopus 로고    scopus 로고
    • Open randomised controlled trial of inhaled nitric oxide and early dexamethasone in high-risk preterm infants
    • Subhedar NV, Ryan SW, Shaw NJ. Open randomised controlled trial of inhaled nitric oxide and early dexamethasone in high-risk preterm infants. Arch Dis Child 1997; 77:F185-F190.
    • (1997) Arch Dis Child , vol.77
    • Subhedar, N.V.1    Ryan, S.W.2    Shaw, N.J.3
  • 31
    • 0033604133 scopus 로고    scopus 로고
    • Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: A randomised controlled trial
    • Kinsella JP, Walsh WF, Bose CL, et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 1999; 354:1061-1065.
    • (1999) Lancet , vol.354 , pp. 1061-1065
    • Kinsella, J.P.1    Walsh, W.F.2    Bose, C.L.3
  • 32
    • 0033604020 scopus 로고    scopus 로고
    • Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: A randomised controlled trial
    • The Franco-Belgium Collaborative NO Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. Lancet 1999; 354:1066-1071.
    • (1999) Lancet , vol.354 , pp. 1066-1071
  • 33
    • 20044376296 scopus 로고    scopus 로고
    • The safety and efficacy of nitric oxide therapy in premature infants
    • Hascoet JM, Fresson J, Claris O, et al. The safety and efficacy of nitric oxide therapy in premature infants. J Pediatr 2005; 146:318-323. Report of an unblinded trial of INO treatment in premature newborns. No differences were found in major outcome measures or adverse events.
    • (2005) J Pediatr , vol.146 , pp. 318-323
    • Hascoet, J.M.1    Fresson, J.2    Claris, O.3
  • 34
    • 14844314499 scopus 로고    scopus 로고
    • Inhaled nitric oxide for preterm infants: A therapy in search of an indication? The search continues
    • Finer NN. Inhaled nitric oxide for preterm infants: A therapy in search of an indication? The search continues. J Pediatr 2005; 146:301-302.
    • (2005) J Pediatr , vol.146 , pp. 301-302
    • Finer, N.N.1
  • 35
    • 17744387330 scopus 로고    scopus 로고
    • Early inhaled nitric oxide improves oxidative balance in very preterm infants
    • Hamon I, Fresson J, Nicolas MB, et al. Early inhaled nitric oxide improves oxidative balance in very preterm infants. Pediatr Res 2005; 57:637-643. Serum samples from patients enrolled in the Hascoet trial [33] were analyzed for markers of oxidant stress. Inhaled NO improved oxidative balance compared with controls.
    • (2005) Pediatr Res , vol.57 , pp. 637-643
    • Hamon, I.1    Fresson, J.2    Nicolas, M.B.3
  • 36
    • 22444433630 scopus 로고    scopus 로고
    • Neonatal ventilation with inhaled nitric oxide versus ventilatory support without inhaled nitric oxide for preterm infants with severe respiratory failure: The INNOVO multicentre randomized controlled trial
    • Field D, Elbourne D, Truesdale A, et al. Neonatal ventilation with inhaled nitric oxide versus ventilatory support without inhaled nitric oxide for preterm infants with severe respiratory failure: The INNOVO multicentre randomized controlled trial. Pediatrics 2005; 115:926-936. An unblinded trial of INO in 108 premature newborns with severe lung disease. No differences were found in major outcome measures or adverse events.
    • (2005) Pediatrics , vol.115 , pp. 926-936
    • Field, D.1    Elbourne, D.2    Truesdale, A.3
  • 37
    • 13544258802 scopus 로고    scopus 로고
    • Nitric oxide still no consensus
    • Field DJ. Nitric oxide still no consensus. Early Hum Dev 2005; 81:1-4.
    • (2005) Early Hum Dev , vol.81 , pp. 1-4
    • Field, D.J.1
  • 38
    • 0344943241 scopus 로고    scopus 로고
    • Inhaled nitric oxide in premature infants with the respiratory distress syndrome
    • Schreiber MD, Gin-Mestan K, Marks JD, et al. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med 2003; 349:2099-2107.
    • (2003) N Engl J Med , vol.349 , pp. 2099-2107
    • Schreiber, M.D.1    Gin-Mestan, K.2    Marks, J.D.3
  • 39
    • 21444459262 scopus 로고    scopus 로고
    • Inhaled nitric oxide for premature infants with severe respiratory failure
    • Van Meurs KP, Wright LL, Ehrenkranz RA, et al. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 2005; 353:13-22. The largest RCT of INO in premature newborns published to date. There were no differences in major outcome measures. In post-hoc analyses, however, INO treatment decreased the incidence of death/BPD in infants with birthweights greater than 1000 g, and infants with birthweights no more than 1000 g had higher mortality and increased rates of severe ICH.
    • (2005) N Engl J Med , vol.353 , pp. 13-22
    • Van Meurs, K.P.1    Wright, L.L.2    Ehrenkranz, R.A.3
  • 40
    • 21444434255 scopus 로고    scopus 로고
    • Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide
    • Mestan KK, Marks JD, Hecox K, et al. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med 2005; 353: 23-32. In this single-center, masked, RCT, 207 patients were randomized to treatment with INO versus control. Neurodevelopmental outcomes were studied in 138 children at 2 years of age. Treatment with INO in the newborn period was associated with improved neurodevelopmental outcomes.
    • (2005) N Engl J Med , vol.353 , pp. 23-32
    • Mestan, K.K.1    Marks, J.D.2    Hecox, K.3


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