H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A

Life Sciences

Volumn 80, Issue 5, 2007, Pages 476-483

  Kato, Yoshiro ^a   Ozaki, Nobuaki ^a   Yamada, Tsutomu ^a   Miura, Yoshitaka ^a   Oiso, Yutaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

3T3 L1 cells; Adipogenesis; Akt; Extracellular signal regulated kinase 1 2; H 89; Phosphoinositide 3 kinase; Protein kinase A; Ras; Rho kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RHO KINASE; WORTMANNIN;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; BLOTTING, WESTERN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULIN; ISOQUINOLINES; MICE; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 33845764280     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.09.029     Document Type: Article

References (36)

1. Begum N., Sandu O.A., Ito M., Lohmann S.M., and Smolenski A. Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. The Journal of Biological Chemistry 277 8 (2002) 6214-6222
2. Bernlohr D.A., Bolanowski M.A., Kelly Jr. T.J., and Lane M.D. Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes. The Journal of Biological Chemistry 260 9 (1985) 5563-5567
3. Bost F., Aouadi M., Caron L., Even P., Belmonte N., Prot M., Dani C., Hofman P., Pages G., Pouyssegur J., Le Marchand-Brustel Y., and Binetruy B. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54 2 (2005) 402-411
4. Chijiwa T., Mishima A., Hagiwara M., Sano M., Hayashi K., Inoue T., Naito K., Toshioka T., and Hidaka H. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. The Journal of Biological Chemistry 265 9 (1990) 5267-5272
5. Cowherd R.M., Lyle R.E., and McGehee Jr. R.E. Molecular regulation of adipocyte differentiation. Seminars in Cell and Developemental Biology 10 1 (1999) 3-10
6. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemical Journal 351 Pt1 (2000) 95-105
7. Day R.N., Walder J.A., and Maurer R.A. A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription. The Journal of Biological Chemistry 264 1 (1989) 431-436
8. Font de Mora J., Porras A., Ahn N., and Santos E. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Molecular and Cellular Biology 17 10 (1997) 6068-6075
9. Green H., and Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5 1 (1975) 19-27
10. Gregoire F.M., Smas C.M., and Sul H.S. Understanding adipocyte differentiation. Physiological Reviews 78 3 (1998) 783-809
11. Hausman D.B., DiGirolamo M., Bartness T.J., Hausman G.J., and Martin R.J. The biology of white adipocyte proliferation. Obesity Reviews 2 4 (2001) 239-254
12. Kim S.W., Muise A.M., Lyons P.J., and Ro H.S. Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation. The Journal of Biological Chemistry 276 13 (2001) 10199-10206
13. Kohn A.D., Summers S.A., Birnbaum M.J., and Roth R.A. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. The Journal of Biological Chemistry 271 49 (1996) 31372-31378
14. Konda Y., Gantz I., DelValle J., Shimoto Y., Miwa H., and Yamada T. Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor. The Journal of Biological Chemistry 269 18 (1994) 13162-13166
15. Krepinsky J.C., Ingram A.J., Tang D., Wu D., Liu L., and Scholey J.W. Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. Journal of the American Society of Nephrology 14 11 (2003) 2790-2800
16. Leemhuis J., Boutillier S., Schmidt G., and Meyer D.K. The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase. The Journal of Pharmacology and Experimental Therapeutics 300 3 (2002) 1000-1007
17. Li J., Takaishi K., Cook W., McCorkle S.K., and Unger R.H. Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proceedings of the National Academy of Sciences of the United States of America 100 16 (2003) 9476-9481
18. Li Y., Wang P., Xu J., and Desir G.V. Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. American Journal of Physiology. Cell Physiology 290 2 (2006) C345-C351
19. MacDougald O.A., and Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annual Review of Biochemistry 64 (1995) 345-373
20. Magun R., Burgering B.M., Coffer P.J., Pardasani D., Lin Y., Chabot J., and Sorisky A. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137 8 (1996) 3590-3593
21. Miki T., Minami K., Zhang L., Morita M., Gonoi T., Shiuchi T., Minokoshi Y., Renaud J.M., and Seino S. ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. American Journal of Physiology. Endocrinology, Metabolism and Gastrointestinal Physiology 283 6 (2002) E1178-E1184
22. Ouchi N., Kihara S., Funahashi T., Matsuzawa Y., and Walsh K. Obesity, adiponectin and vascular inflammatory disease. Current Opinion in Lipidology 14 6 (2003) 561-566
23. Prusty D., Park B.H., Davis K.E., and Farmer S.R. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPAR γ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes. The Journal of Biological Chemistry 277 48 (2002) 46226-46232
24. Smith P.J., Wise L.S., Berkowitz R., Wan C., and Rubin C.S. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. The Journal of Biological Chemistry 263 19 (1988) 9402-9408
25. Son Y.K., Park W.S., Kim S.J., Earm Y.E., Kim N., Youm J.B., Warda M., Kim E., and Han J. Direct inhibition of a PKA inhibitor, H-89 on KV channels in rabbit coronary arterial smooth muscle cells. Biochemical and Biophysical Research Communications 341 4 (2006) 931-937
26. Sordella R., Jiang W., Chen G.C., Curto M., and Settleman J. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113 2 (2003) 147-158
27. Spiegelman B.M. PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47 4 (1998) 507-514
28. Sun Park W., Kyoung Son Y., Kim N., Boum Youm J., Joo H., Warda M., Ko J.H., Earm Y.E., and Han J. The protein kinase A inhibitor, H-89, directly inhibits KATP and Kir channels in rabbit coronary arterial smooth muscle cells. Biochemical and Biophysical Research Communications 340 4 (2006) 1104-1110
29. Taha C., and Klip A. The insulin signaling pathway. Journal of Membrane Biology 169 1 (1999) 1-12
30. Thompson G.M., Trainor D., Biswas C., LaCerte C., Berger J.P., and Kelly L.J. A high-capacity assay for PPARγ ligand regulation of endogenous aP2 expression in 3T3-L1 cells. Analytical Biochemistry 330 1 (2004) 21-28
31. Tomiyama K., Nakata H., Sasa H., Arimura S., Nishio E., and Watanabe Y. Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochemical and Biophysical Research Communications 212 1 (1995) 263-269
32. Uehara T., Chihara T., Tokumitsu Y., and Nomura Y. Possible involvement of pertussis toxin-sensitive GTP-binding protein(s) in c-fos expression during differentiation of 3T3-L1 fibroblasts to adipocytes. Biochimica et Biophysica Acta 1088 1 (1991) 41-46
33. Uehara T., Hoshino S., Ui M., Tokumitsu Y., and Nomura Y. Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C. Biochimica et Biophysica Acta 1224 2 (1994) 302-310
34. Xu J., and Liao K. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. The Journal of Biological Chemistry 279 34 (2004) 35914-35922
35. Yokozaki H., Tortora G., Pepe S., Maronde E., Genieser H.G., Jastorff B., and Cho-Chung Y.S. Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Research 52 9 (1992) 2504-2508
36. Zhang B., Berger J., Zhou G., Elbrecht A., Biswas S., White-Carrington S., Szalkowski D., and Moller D.E. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ. The Journal of Biological Chemistry 271 50 (1996) 31771-31774