Burkholderia cenocepacia J2315 acyl carrier protein: A potential target for antimicrobials' development?

Microbial Pathogenesis

Volumn 45, Issue 5-6, 2008, Pages 331-336

  Sousa, Sílvia A ^a   Ramos, Christian G ^a   Almeida, Filipe ^a   Meirinhos Soares, Luís ^b   Wopperer, Julia ^c   Schwager, Stephan ^c   Eberl, Leo ^c   Leitão, Jorge H ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b INFARMED)   (Portugal)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Acyl carrier protein; Biofilm; Burkholderia cenocepacia J2315; Caenorhabditis elegans model of infection; Virulence

Indexed keywords

ACYL CARRIER PROTEIN; AMINO ACID; ANTIINFECTIVE AGENT; FATTY ACID;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BIOFILM; BIOSYNTHESIS; BURKHOLDERIA CENOCEPACIA; CAENORHABDITIS ELEGANS; CELL SURFACE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENOME; HYDROPHOBICITY; IN VITRO STUDY; METABOLISM; MOLECULAR WEIGHT; NEMATODE; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL;

ACYL CARRIER PROTEIN; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BIOFILMS; BURKHOLDERIA CEPACIA COMPLEX; BURKHOLDERIA INFECTIONS; CAENORHABDITIS ELEGANS; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); BURKHOLDERIA; BURKHOLDERIA CENOCEPACIA; BURKHOLDERIA CEPACIA COMPLEX; BURKHOLDERIA MALLEI; BURKHOLDERIA PSEUDOMALLEI; CAENORHABDITIS ELEGANS; ESCHERICHIA COLI;

EID: 56749152413     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2008.08.002     Document Type: Article

References (26)

1. Govan J.R., and Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60 (1996) 539-574
2. Mahenthiralingam E., Urban T.A., and Goldberg J.B. The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol 3 (2005) 144-156
3. LiPuma J.J., Spilker T., Gill L.H., Campbell III P.W., Liu L., and Mahenthiralingam E. Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis. Am J Respir Crit Care Med 164 (2001) 92-96
4. Speert D.P. Advances in Burkholderia cepacia complex. Paediatr Respir Rev 3 (2002) 230-235
5. Leitão JH, Sousa SA, Cunha MV, Salgado MJ, Melo-Cristino J, Barreto MC, et al. Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center. Eur J Clin Microbiol Infect Dis, 2008. doi:10.1007/s10096-008-0552-0.
6. Zhou J., Chen Y., Tabibi S., Alba L., Garber E., and Saiman L. Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Antimicrob Agents Chemother 51 (2007) 1085-1088
7. Byers D.M., and Gong H. Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family. Biochem Cell Biol 85 (2007) 649-662
8. White S.W., Zheng J., Zhang Y.-M., and Rock C.O. The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem 74 (2005) 791-831
9. Zhang Y.-M., Frank M.W., Virga K.G., Lee R.E., Rock C.O., and Jackowsi S. Acyl carrier protein is a cellular target for the antibacterial action of pantothenamide class of pantothenate antimetabolites. J Biol Chem 279 (2004) 50969-50975
10. Cardona S.T., Wopperer J., Eberl L., and Valvano M.A. Diverse pathogenicity of Burkholderia cepacia complex strains in the Caenorhabditis elegans host model. FEMS Microbiol Lett 250 (2005) 97-104
11. Dennis J.J., and Zylstra G.J. Plasposons: modular self-cloning minitransposon derivatives for rapid genetic analysis of gram-negative bacterial genomes. Appl Environ Microbiol 64 (1998) 2710-2715
12. Moreira L.M., Videira P.A., Sousa S.A., Leitão J.H., Cunha M.V., and Sá-Correia I. Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide. Biochem Biophys Res Commun 312 (2003) 323-333
13. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual (1989), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
14. De Lay N.R., and Cronan J.E. Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J Bacteriol 188 (2006) 287-296
15. Yoshimura M., Oshima T., and Ogasawara N. Involvement of the YneS/YgiH and PlsX proteins in phospholipid biosynthesis in both Bacillus subtilis and Escherichia coli. BMC Microbiol 7 (2007) 69
16. Sousa S.A., Moreira L.M., Wopperer J., Eberl L., Sá-Correia I., and Leitão J.H. The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities. Biochem Biophys Res Commun 353 (2007) 200-206
17. Rosenberg M. Bacterial adherence to polystyrene: a replica method of screening for bacterial hydrophobicity. Appl Environ Microbiol 42 (1981) 375-377
18. Steidle A., Siegl K., Schuhegger R., Ihring A., Schmid M., Gantner S., et al. Visualization of N-acylhomoserine lactone (AHL)-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere. Appl Environ Microbiol 67 (2001) 5761-5770
19. Roujeinikova A., Simon W.J., Gilroy J., Rice D.W., Rafferty J.B., and Slabas A.R. Structural studies of fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit longer substrates. J Mol Biol 365 (2007) 135-145
20. Markowitz V.M., Szeto E., Palaniappan K., Grechkin Y., Chu K., Chen I.M., et al. The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions. Nucleic Acids Res 36 (2008) D528-D533
21. Schwede T., Kopp J., Guex N., and Peitsch M.C. SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 31 (2003) 3381-3385
22. Wopperer J., Cardona S.T., Huber B., Jacobi C.A., Valvano M.A., and Eberl L. A quorum-quenching approach to investigate the conservation of quorum-sensing-regulated functions within the Burkholderia cepacia complex. Appl Environ Microbiol 72 (2006) 1579-1587
23. Rosenberg M., Gutnick D., and Rosenberg E. Adherence of bacteria to hydrocarbons: a simple method for measuring cell surface hydrophobicity. FEMS Microbiol Lett 9 (1980) 29-33
24. Roberts T.M., and Ward S. Membrane flow during spermiogenesis. J Cell Biol 92 (1992) 113-120
25. Moy T.I., Ball A.R., Anklesaria Z., Casadei G., Lewis K., and Ausubel F.M. Identification of novel antimicrobials using a live-animal infection model. Proc Natl Acad Sci U S A 103 (2006) 10414-10419
26. Thompson J.D., Higgins D.G., and Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22 (1994) 4673-4680