Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes

Toxicological Sciences

Volumn 106, Issue 2, 2008, Pages 454-463

  Wang, Ya Jean ^a   Chen, Bing Shuo ^a,b   Lin, Ming Wei ^a   Lin, An An ^a   Peng, Hsung ^a   Sung, Ruey J ^c   Wu, Sheng Nan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

Aconitine; Action potential; H9c2 cell; Multielectrode array recording; Neonatal rat ventricular myocyte; Ultrarapid delayed rectifier K+ current

Indexed keywords

ACONITINE; CALCIUM; CARDIOTOXIN; DELAYED RECTIFIER POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CARDIOTOXICITY; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; EMBRYO; HEART CELL CULTURE; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; IC 50; MYOBLAST; NONHUMAN; POTASSIUM CURRENT; RAT; REACTION TIME; STEADY STATE;

ACONITINE; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CELL LINE; ELECTRODES; HEART VENTRICLES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RUTHENIUM RED;

RATTUS;

EID: 56649106681     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn189     Document Type: Article

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