Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney

Molecular and Cellular Endocrinology

Volumn 171, Issue 1-2, 2001, Pages 21-24

  Quinkler, M ^a   Johanssen, S ^a   Bumke Vogt, C ^a   Oelkers, W ^a   Bahr V ^a   Diederich, S ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Mineralocorticoid receptor; Progesterone; Progesterone metabolism

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 17,20BETA DIHYDROXYPREGN 4 EN 3 ONE; 20ALPHA DIHYDRO,5ALPA DIHYDROPROGESTERONE; 20ALPHA DIHYDROPROGESTERONE; 3BETA,5ALPHA TETRAHYDROPROGESTERONE; 5ALPHA PREGNANE 3,20 DIONE; ALDOSTERONE; CARBON 14; ENZYME; HYDROCORTISONE; HYDROXYPROGESTERONE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; PROGESTERONE; UNCLASSIFIED DRUG;

ALDOSTERONE BLOOD LEVEL; ARTICLE; CELL FRACTIONATION; KIDNEY; KIDNEY HOMOGENATE; POSTMENOPAUSE; PREGNANCY; PREMENOPAUSE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROGESTERONE METABOLISM; PROTECTION; REDUCTION;

20-ALPHA-DIHYDROPROGESTERONE; CARBON RADIOISOTOPES; CELL NUCLEUS; CYTOSOL; FEMALE; HUMANS; KIDNEY; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; MICROSOMES; MITOCHONDRIA; POSTMENOPAUSE; PREMENOPAUSE; PROGESTERONE; RECEPTORS, MINERALOCORTICOID; SUBCELLULAR FRACTIONS;

EID: 0035931332     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00429-9     Document Type: Article

References (13)

1. Deoxycortico-sterone sulfate biosynthesis in human fetal kidney
2. Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
3. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
4. Localization of 11β-hydroxysteroid dehydrogenase-tissue-specific protector of the mineralocorticoid receptor
5. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
6. Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex
7. Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution
8. Progesterone binding to mineralocorticoid receptors: in vitro and in vivo studies
9. Close kinship of human 20α-hydroxysteroid dehydrogenase gene with three aldo-keto, reductase genes
10. Progesterone metabolism in the human kidney and inhibition of 11β-hydroxysteroid dehydrogenase type 2 by progesterone and its metabolites
11. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands
12. The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent
13. Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action