Aromatase and intracrinology of estrogen in hormone-dependent tumors

Oncology

Volumn 57, Issue SUPPL. 2, 1999, Pages 7-15

  Harada, Nobuhiro ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

17 Hydroxysteroid dehydrogenase; Alternative exon 1; Autocrine action; Estrogen receptor; Estrogen sulfotransferase; Paracrine action; Steroid sulfatase; Tissue specific expression

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; STEROID HORMONE; STERYL SULFATASE; SULFOTRANSFERASE; TESTOSTERONE 17BETA DEHYDROGENASE;

CANCER GROWTH; CONFERENCE PAPER; ENZYME REGULATION; EXON; HORMONAL REGULATION; PRIORITY JOURNAL; PROMOTER REGION; STEROID BLOOD LEVEL; STEROID METABOLISM; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; AROMATASE; AUTOCRINE COMMUNICATION; ESTROGENS; EXONS; FEMALE; HUMANS; NEOPLASMS, HORMONE-DEPENDENT; SULFOTRANSFERASES; TISSUE DISTRIBUTION;

EID: 0032718655     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055270     Document Type: Conference Paper

References (61)

1. Means GD, Kilgore MW, Mahendroo MS, Mendelson CR, Simpson ER: Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol Endocrinol 1991;5:2005-2013.
2. Mahendroo MS, Means GD, Mendelson CR, Simpson ER: Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta. J Biol Chem 1991;266:11276-11281.
3. Harada N, Utsumi T, Takagi Y: Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA 1993;90:11312-11316.
4. Labrie F, Dupont A, Simard J, Luu-The V, Belanger A: Intracrinology: The basis for the rational design of endocrine therapy at all stages of prostate cancer. Eur Urol 1994;24:94-103.
5. Labrie F, Belanger A, Simart J, Luu-The V, Labrie C: DHEA and peripheral androgen and estrogen formation: Intracrinology. Ann NY Acad Sci 1995;774:16-28.
6. Sasano H, Suzuki T, Harada N: From endocrinology to intracrinology. Endocr Pathol 1998; 9:9-20.
7. Sasano H, Harada N: Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr Rev 1998;19:593-607.
8. Henderson IC, Canellos GP: Cancer of the breast. The past decade. N Engl J Med 1980; 302:17-30.
9. Miller WR, Hawkins RA, Forrest APM: Significance of aromatase activity in human breast cancer. Cancer Res 1982;42:3365-3368.
10. Lipton A, Santner SJ, Santen RJ, Harvey HA, Feil PD, White-Hershey D, Bartholomew MJ, Antle CE: Aromatase activity in primary and metastatic human breast cancer. Cancer 1987; 59:779-782.
11. Thorsen T, Tangen M, Stoa KF: Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol. Eur J Cancer Clin Oncol 1982;18:333-337.
12. van Landeghem AAJ, Portman J, Mabauurs M: Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res 1985;45: 2900-2906.
13. Naftolin F, Ryan KJ, Petro Z: Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats. Endocrinology 1972;90:295-298.
14. Smuk M, Schwers J: Aromatization of androstenedione by human adult liver in vitro. J Clin Endocrinol Metab 1977;45:1009-1012.
15. Schweikert HU, Milewich L, Wilson JD: Aromatization of androstenedione by cultured human fibroblasts. J Clin Endocrinol Metab 1976;43:785-795.
16. Grodin JM, Siiteri PK, MacDonald PC: Source of estrogen production in the postmenopausal woman. J Clin Endocrinol Metab 1973;36: 207-214.
17. Sasano H, Uzuki M, Sawai T, Nagura H, Matsunaga G, Kashimoto O, Harada N: Aromatase in human bone tissue. J Bone Miner Res 1997; 12:1416-1423.
18. Harada N, Sasano H, Murakami H, Ohkuma T, Nagura H, Takagi Y: Localized expression of aromatase in human vascular tissues. Circ Res 1999;84:1285-1291.
19. Sasano H, Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG: Immunolocalization of aromatase, 17alpha-hydroxylase and side-chain-cleavage cytochromes P-450 in the human ovary. J Reprod Fertil 1989;85:163-169.
20. Naganuma H, Ohtani H, Harada N, Nagura H: Immunoelectron microscopic localization of aromatase in human placenta and ovary using microwave fixation. J Histochem Cytochem 1990;38:1427-1432.
21. Naftolin F, Horvath TL, Jakab RL, Leranth C, Harada N, Balthazart J: Aromatase immunoreactivity in axon terminals of the vertebrate brain. An immunocytochemical study on quail, rat, monkey and human tissues. Neuroendocrinology 1996;63:149-155.
22. Santen RJ, Martel J, Hoagland M, Naftolin F, Roa L, Harada N, Hafer L, Zaino R, Santner SJ: Stromal spindle cells contain aromatase in human breast tumors. J Clin Endocrinol Metab 1994;79:627-632.
23. Sasano H, Nagura H, Harada N, Goukon Y, Kimura M: Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol 1994;25:530-535.
24. Esteban JM, Warsi Z, Haniu M, Hall P, Shively JE, Chen S: Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation. Am J Pathol 1992;140:337-343.
25. Lu Q, Nakmura J, Savinov A, Yue W, Weisz J, Dabbs DJ, Wolz G, Brodie A: Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology 1996;137:3061-3068.
26. Watanabe K, Sasano H, Harada N, Ozaki M, Niikura H, Satao S, Yajima A: Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. Am J Pathol 1995;146:491-500.
27. Harada N, Ota H, Yoshimura N, Katsuyama T, Takagi Y: Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver. J Clin Endocrinol Metab 1998;83:697-702.
28. Kaga K, Sasano H, Harada N, Ozaki M, Sato S, Yajima A: Aromatase in human common epithelial ovarian neoplasms. Am J Pathol 1996; 149:45-51.
29. Hiramatsu M, Maehara I, Ozaki M, Harada N, Orikasa S, Sasano H: Aromatase in hyperplasia and carcinoma of the human prostate. Prostate 1997;31:118-124.
30. Harada N, Yamada K, Saito K, Kibe N, Dohmae S, Takagi Y: Structural characterization of the human estrogen synthetase (aromatase) gene. Biochem Biophys Res Commun 1990; 166:365-372.
31. Harada N, Honda S: Molecular analysis of aberrant expression of aromatase in breast cancer tissues. Breast Cancer Res Treat 1998; 49(suppl 1):S15-S21; discussion S33-S17.
32. Yamada K, Harada N, Honda S, Takagi Y: Regulation of placenta-specific expression of the aromatase cytochrome P-450 gene. J Biol Chem 1995;270:25064-25069.
33. Honda S, Harada N, Abe-Dohmae S, Takagi Y: Identification of cis-acting elements in the proximal promoter region for the brain-specific exon 1 of the mouse aromatase gene. Mol Brain Res 1999;66:122-132.
34. Harada N, Ogawa H, Shozu M, Yamada K, Suhara K, Nishida E, Takagi Y: Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency. J Biol Chem 1992;267:4781-4785.
35. Ito Y, Fisher CR, Conte FA, Grumbach MM, Simpson ER: Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci USA 1993;90:11673-11677.
36. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995;80:3689-3698.
37. Mullis PE, Yoshimura N, Kuhlmann B, Lippuner K, Jaeger P, Harada H: Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: Impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood. J Clin Endocrinol Metab 1997;82:1739-1745.
38. Fisher CR, Graves KH, Parlow AF, Simpson ER: Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998;95:6965-6970.
39. Honda S, Harada N, Ito S, Takagi Y, Maeda S: Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun 1998;252:445-449.
40. Stephenson J: More evidence links NSAID, estrogen use with reduced Alzheimer risk. JAMA 1996;275:1389-1390.
41. Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R: Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;348:429-432.
42. Horowitz MC: Cytokines and estrogen in bone: Anti-osteoporotic effects. Science 1993;260: 626-627.
43. O' Malley BW, Strott CA: Steroid hormones: Metabolism and mechanism of action; in Yen SSC, Jaffe RB (eds): Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management, ed 3. Philadelphia, Saunders, 1991, pp 156-180.
44. Younes MA, Besch NF, Besch PK: Estradiol and progesterone binding in human term placental cytosol. Am J Obstet Gynecol 1981;141: 170-174.
45. Bojar H, Balzer K, Dreyfurst R, Staib W, Wittliff JL: Identification and partial characterization of specific oestrogen-binding components in human kiney. J Clin Chem Clin Biochem 1976;14:515-520.
46. Ganesan S, Bashirelahi N, Young JD, Cohen SP: Phenylmethylsulfonyl fluoride (PMSF) inhibits 17 beta-estradiol binding to estrogen receptor from human prostate. Life Sci 1987;41: 2767-2776.
47. Tamaya T, Motoyama T, Ohono Y, Ide N, Tsurusaki T, Okada H: Steroid receptor levels and histology of endometriosis and adenomyosis. Fertil Steril 1979;31:396-400.
48. Nagasue N, Ito A, Yukaya H, Ogawa Y: Estrogen receptors in hepatocellular carcinoma. Cancer 1986;57:87-91.
49. Moore MR: An insulin effect on cytoplasmic estrogen receptor in the human breast cancer cell line MCF-7. J Biol Chem 1981;256:3637-3640.
50. MacDonald PC, Grodin JM, Edman CD, Vellios F, Siiteri PK: Origin of estrogen in a postmenopausal woman with a non endocrine tumor of the ovary and endometrial hyperplasia. Obstet Gynecol 1976;47:644-650.
51. Cleland WH, Mendelson CR, Simpson ER: Effects of aging and obesity on aromatase activity of human adipose cells. J Clin Endocrinol Metab 1985;60:174-177.
52. Bulun SE, Simpson ER: Competitive reverse transcription-polymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. J Clin Endocrinol Metab 1994;78:428-432.
53. Santen RJ: Introduction to the conference, aromatase: New perspectives for breast cancer. Cancer Res 1982;42:3268s.
54. Pasqualini JR, Gelly C, Nguyen BL, Vella C: Importance of estrogen sulfates in breast cancer. J Steroid Biochem 1989;34:155-163.
55. Noel CT, Reed MJ, Jacobs HS, James VH: The plasma concentration of oestrone sulphate in postmenopausal women: Lack of diurnal variation, effect of ovariectomy, age and weight. J Steroid Biochem 1981;14:1101-1105.
56. Ruder HJ, Loriaux L, Lipsett MB: Estrone sulfate: Production rate and metabolism in man. J Clin Invest 1972;51:1020-1033.
57. Harada N, Yamada K: Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction. Endocrinology 1992;131:2306-2312.
58. Utsumi T, Harada N, Maruta M, Takagi Y: Presence of alternatively spliced transcripts of aromatase gene in human breast cancer. J Clin Endocrinol Metab 1996;81:2344-2349.
59. Utsumi T, Yoshimura N, Takeuchi S, Ando J, Maruta M, Maeda K, Harada N: Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res 1999;59:377-381.
60. Silva MC, Rowlands MG, Dowsett M, Gusterson B, McKinna JA, Fryatt I, Coombes RC: Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res 1989; 49:2588-2591.
61. Sasano H, Frost AR, Saitoh R, Harada N, Poutanen M, Vihko R, Bulun SE, Silverberg SG, Nagura H: Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J Clin Endocrinol Metab 1996;81: 4042-4046.