The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein

Free Radical Biology and Medicine

Volumn 45, Issue 12, 2008, Pages 1622-1630

  Malaisé, Muriel ^a   Schätzl, Hermann M ^b   Bürkle, Alexander ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antioxidant; Copper; Mitochondrial membrane potential; Prion protein; ROS detection; Signaling

Indexed keywords

COPPER; PRION PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; TRANSMEMBRANE REGION; WILD TYPE;

ANIMALS; ANTIOXIDANTS; COPPER; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NEUROBLASTOMA; OXIDANTS; OXIDATIVE STRESS; PRIONS; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION;

EID: 56349162928     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.08.024     Document Type: Article

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