Aggravation of ischemic brain injury by prion protein deficiency: Role of ERK-1/-2 and STAT-1

Neurobiology of Disease

Volumn 20, Issue 2, 2005, Pages 442-449

  Spudich, Annett ^a   Frigg, Rico ^b,c   Kilic, Ertugrul ^a   Kilic, Ülkan ^a   Oesch, Bruno ^c   Raeber, Alex ^c   Bassetti, Claudio L ^a   Hermann, Dirk M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c Prionics AG   (Switzerland)

Author keywords

ERK 1 2; Middle cerebral artery occlusion; Neuroprotection; STAT 1

Indexed keywords

CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PRION PROTEIN; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN VARIANT; SIGNAL TRANSDUCTION; STROKE; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; APOPTOSIS; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CASPASES; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFARCTION, MIDDLE CEREBRAL ARTERY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PRPC PROTEINS; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 26944462341     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.04.002     Document Type: Article

References (32)

1. A. Alessandrini, S. Natura, M.A. Moskowitz, and J.V. Bonventre MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia Proc. Natl. Acad. Sci. U. S. A. 96 22 1999 12866 12869
2. P.E. Bendheim, H.R. Brown, R.D. Rudelli, L.J. Scala, N.L. Goller, G.Y. Wen, R.J. Kascsak, N.R. Cashman, and D.C. Bolton Nearly ubiquitous tissue distribution of the scrapie agent precursor protein Neurology 42 1992 149 156
3. D.R. Brown, K. Qin, J.W. Herms, A. Madlung, J. Manson, R. Strome, P.E. Fraser, T. Kruck, A. von Bohlen, W. Schulz-Schaeffer, A. Giese, D. Westaway, and H. Kretzschmar The cellular prion protein binds copper in vivo Nature 390 1997 684 687
4. D.R. Brown, B. Schmidt, and H.A. Kretzschmar Effects of oxidative stress on prion protein expression in PC12 cells Int. J. Dev. Neurosci. 15 1997 961 972
5. D.R. Brown, I.K. Iordanova, B.S. Wong, C. Venien-Bryan, F. Hafiz, L.L. Glasssmith, M.S. Sy, P. Gambetti, I.M. Jones, C. Clive, and S.J. Haswell Functional and structural differences between the prion protein from two alleles prnp(a) and prnp(b) of mouse Eur. J. Biochem. 267 2000 2452 2459
6. H. Büeler, M. Fischer, Y. Lang, H. Bluethmann, H.P. Lipp, S.J. DeArmond, S.B. Prusiner, M. Aguet, and C. Weissmann Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein Nature 356 1992 577 582
7. N.R. Cashman, R. Loertscher, J. Nalbantoglu, I. Shaw, R.J. Kascsak, D.C. Bolton, and P.E. Bendheim Cellular isoform of the scrapie agent protein participates in lymphocyte activation Cell 61 1990 185 192
8. L.B. Chiarini, A.R. Freitas, S.M. Zanata, R.R. Brentani, V.R. Martins, and R. Linden Cellular prion protein transduces neuroprotective signals EMBO J. 21 2002 3317 3326
9. V.C. Dodelet, and N.R. Cashman Prion protein expression in human leukocyte differentiation Blood 91 1998 1556 1561
10. I. Ferrer, B. Friguls, E. Dalfo, and A.M. Planas Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia Acta Neuropathol. (Berl) 105 2003 425 437
11. M. Fischer, T. Rülicke, A. Raeber, A. Sailer, M. Moser, B. Oesch, S. Brandner, A. Aguzzi, and C. Weissmann Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie EMBO J. 15 1996 1255 1264
12. N. Genoud, A. Behrens, G. Miele, D. Robay, F.L. Heppner, S. Freigang, and A. Aguzzi Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions Proc. Natl. Acad. Sci. U. S. A. 101 2004 4198 4203
13. D.M. Hermann, E. Kilic, S. Kügler, S. Isenmann, and M. Bähr Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice Neurobiol. Dis. 8 2001 655 666
14. D.M. Hermann, E. Kilic, R. Hata, K.A. Hossmann, and G. Mies Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice Neuroscience 104 4 2001 947 955
15. L. Hirt, J. Badaut, J. Thevenet, C. Granziera, L. Regli, F. Maurer, C. Bonny, and J. Bogousslavsky D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia Stroke 35 2004 1738 1743
16. S. Janjua, A. Stephanou, and D.S. Latchman The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis Cell Death Differ. 9 2002 1140 1146
17. L is protective after middle cerebral artery occlusion in mice Ann. Neurol. 52 2002 617 622
18. Ü. Kilic, E. Kilic, J. Soliz, C.L. Bassetti, M. Gassmann, and D.M. Hermann Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2 FASEB J. 19 2005 249 251
19. C) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation Mol. Brain Res. 124 2004 40 50
20. C. Kuwahara, A.M. Takeuchi, T. Nishimura, K. Haraguchi, A. Kubosaki, Y. Matsumoto, K. Saeki, Y. Matsumoto, T. Yokoyama, S. Itohara, and T. Onodera Prions prevent neuronal cell-line death Nature 400 1999 225 226
21. K. Maeda, R. Hata, M. Bader, T. Walther, and K.-A. Hossmann Larger anastomoses in angiotensinogen-knockout mice attenuate early metabolic disturbances after middle cerebral artery occlusion J. Cereb. Blood Flow Metab. 19 1999 1092 1098
22. J. Manson, J.D. West, V. Thomson, P. McBride, M.H. Kaufman, and J. Hope The prion protein gene: a role in mouse embryogenesis? Development 115 1992 117 122
23. N.F. McLennan, P.M. Brennan, A. McNeill, I. Davies, A. Fotheringham, K.A. Rennison, D. Ritchie, F. Brannan, M.W. Head, J.W. Ironside, A. Williams, and J.E. Bell Prion protein accumulation and neuroprotection in hypoxic brain damage Am. J. Pathol. 165 2004 227 235
24. C. Monnet, J. Gavard, R.M. Mege, and A. Sobel Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells FEBS Lett. 576 2004 114 118
25. J. Pammer, W. Weninger, and E. Tschachler Human keratinocytes express cellular prion-related protein in vitro and during inflammatory skin diseases Am. J. Pathol. 153 1998 1353 1358
26. S.B. Prusiner Novel proteinaceous infectious particles cause scrapie Science 216 1982 136 144
27. C.E. Reilly Nonpathogenic prion protein (PrPc) acts as a cell-surface signal transducer J. Neurol. 247 2000 819 820
28. R. Rossi, A. Cozzio, E. Flechsig, M.A. Klein, T. Rülicke, A. Aguzzi, and C. Weissmann Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain EMBO J. 20 2001 694 702
29. N. Stahl, D.R. Borchelt, K. Hsiao, and S.B. Prusiner Scrapie prion protein contains a phosphatidylinositol glycolipid Cell 51 1987 229 240
30. Y. Wang, E. Kilic, Ü. Kilic, B. Weber, C.L. Bassetti, H.H. Marti, and D.M. Hermann VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena Brain 128 2005 52 63
31. D.A. West, L.M. Valentim, M.F. Lythgoe, A. Stephanou, E. Proctor, L. van der Weerd, R.J. Ordidge, D.S. Latchman, and D.G. Gadian MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia Neuroscience 127 2004 333 339
32. A.R. White, S.J. Collins, F. Maher, M.F. Jobling, L.R. Stewart, J.M. Thyer, K. Beyreuther, C.L. Masters, and R. Cappai Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity Am. J. Pathol. 155 1999 1723 1730