-
2
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002;82:373-428.
-
(2002)
Physiol Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
3
-
-
0037852202
-
The proteasome: Structure, function, and role in the cell
-
Adams J. The proteasome: structure, function, and role in the cell. Cancer Treat Rev 2003;29:3-9.
-
(2003)
Cancer Treat Rev
, vol.29
, pp. 3-9
-
-
Adams, J.1
-
4
-
-
0036240701
-
The proteasome: A novel target for cancer chemotherapy
-
Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433-43.
-
(2002)
Leukemia
, vol.16
, pp. 433-443
-
-
Almond, J.B.1
Cohen, G.M.2
-
6
-
-
0038113600
-
Involvement of the proteasome in various degradative processes in mammalian cells
-
Matthews W, Driscoll J, Tanaka K, Ichihara A, Goldberg AL. Involvement of the proteasome in various degradative processes in mammalian cells. Proc Natl Acad Sci U S A 1989;86:2597-601.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 2597-2601
-
-
Matthews, W.1
Driscoll, J.2
Tanaka, K.3
Ichihara, A.4
Goldberg, A.L.5
-
7
-
-
0037342895
-
Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines
-
Ling YH, Liebes L, Jiang JD, et al. Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 2003;9:1145-54.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1145-1154
-
-
Ling, Y.H.1
Liebes, L.2
Jiang, J.D.3
-
9
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61:3071-6.
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
10
-
-
18544367201
-
NF-κB as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, et al. NF-κB as a therapeutic target in multiple myeloma. J Biol Chem 2002;277:16639-47.
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
-
11
-
-
0036735298
-
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
-
LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002;62:4996-5000.
-
(2002)
Cancer Res
, vol.62
, pp. 4996-5000
-
-
LeBlanc, R.1
Catley, L.P.2
Hideshima, T.3
-
12
-
-
0032976338
-
Prognostic significance of angiogenesis in human pancreatic cancer
-
Ikeda N, Adachi M, Taki T, et al. Prognostic significance of angiogenesis in human pancreatic cancer. Br J Cancer 1999;79:1553-63.
-
(1999)
Br J Cancer
, vol.79
, pp. 1553-1563
-
-
Ikeda, N.1
Adachi, M.2
Taki, T.3
-
13
-
-
0034881006
-
Correlation of postoperative survival and angiogenic growth factors in pancreatic carcinoma
-
Knoll MR, Rudnitzki D, Sturm J, Manegold BC, Post S, Jaeger TM. Correlation of postoperative survival and angiogenic growth factors in pancreatic carcinoma. Hepatogastroenterology 2001;48:1162-5.
-
(2001)
Hepatogastroenterology
, vol.48
, pp. 1162-1165
-
-
Knoll, M.R.1
Rudnitzki, D.2
Sturm, J.3
Manegold, B.C.4
Post, S.5
Jaeger, T.M.6
-
14
-
-
0034657029
-
High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
-
Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000;88:2239-45.
-
(2000)
Cancer
, vol.88
, pp. 2239-2245
-
-
Seo, Y.1
Baba, H.2
Fukuda, T.3
Takashima, M.4
Sugimachi, K.5
-
15
-
-
0035476246
-
Angiogenesis in pancreatic carcinoma: Thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival
-
Fujioka S, Yoshida K, Yanagisawa S, Kawakami M, Aoki T, Yamazaki Y. Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival. Cancer 2001;92:1788-97.
-
(2001)
Cancer
, vol.92
, pp. 1788-1797
-
-
Fujioka, S.1
Yoshida, K.2
Yanagisawa, S.3
Kawakami, M.4
Aoki, T.5
Yamazaki, Y.6
-
16
-
-
0036181371
-
Development of the proteasome inhibitor PS-341
-
Adams J. Development of the proteasome inhibitor PS-341. Oncologist 2002;7:9-16.
-
(2002)
Oncologist
, vol.7
, pp. 9-16
-
-
Adams, J.1
-
17
-
-
0036546501
-
NF-κB in cancer: From innocent bystander to major culprit
-
Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev 2002;2:301-10.
-
(2002)
Nat Rev
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
18
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999;59:2615-22.
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
19
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002;8:2505-11.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
-
20
-
-
0642349188
-
Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts
-
Williams S, Pettaway C, Song R, Papandreou C, Logothetis C, McConkey DJ. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol Cancer Ther 2003;2:835-43.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 835-843
-
-
Williams, S.1
Pettaway, C.2
Song, R.3
Papandreou, C.4
Logothetis, C.5
McConkey, D.J.6
-
21
-
-
0034875305
-
Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome
-
Bold RJ, Virudachalam S, McConkey DJ. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J Surg Res 2001;100:11-7.
-
(2001)
J Surg Res
, vol.100
, pp. 11-17
-
-
Bold, R.J.1
Virudachalam, S.2
McConkey, D.J.3
-
22
-
-
2442510143
-
Phase II trial of PS-341 in patients with renal cell cancer: A University of Chicago phase II consortium study
-
Davis NB, Taber DA, Ansari RH, et al. Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study. J Clin Oncol 2004;22:115-9.
-
(2004)
J Clin Oncol
, vol.22
, pp. 115-119
-
-
Davis, N.B.1
Taber, D.A.2
Ansari, R.H.3
-
23
-
-
4644304196
-
Phase II trial of bortezomib for patients with advanced renal cell carcinoma
-
Kondagunta GV, Drucker B, Schwartz L, et al. Phase II trial of bortezomib for patients with advanced renal cell carcinoma. J Clin Oncol 2004;22:3720-5.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3720-3725
-
-
Kondagunta, G.V.1
Drucker, B.2
Schwartz, L.3
-
24
-
-
2942692143
-
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
-
Papandreou CN, Daliani DD, Nix D, et al. Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol 2004;22:2108-21.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2108-2121
-
-
Papandreou, C.N.1
Daliani, D.D.2
Nix, D.3
-
25
-
-
16544389047
-
Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children's Oncology Group study (ADVL0015)
-
Blaney SM, Bernstein M, Neville K, et al. Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: a Children's Oncology Group study (ADVL0015). J Clin Oncol 2004;22:4804-9.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4804-4809
-
-
Blaney, S.M.1
Bernstein, M.2
Neville, K.3
-
26
-
-
0141706672
-
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
-
Ling YH, Liebes L, Zou Y, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003;278:33714-23.
-
(2003)
J Biol Chem
, vol.278
, pp. 33714-33723
-
-
Ling, Y.H.1
Liebes, L.2
Zou, Y.3
Perez-Soler, R.4
-
27
-
-
4644316230
-
Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis
-
Denlinger CE, Rundall BK, Keller MD, Jones DR. Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis. Ann Thorac Surg 2004;78:120 7-14.
-
(2004)
Ann Thorac Surg
, vol.78
, Issue.120
, pp. 7-14
-
-
Denlinger, C.E.1
Rundall, B.K.2
Keller, M.D.3
Jones, D.R.4
-
28
-
-
0034981649
-
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
-
Shah SA, Potter MW, McDade TP, et al. 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J Cell Biochem 2001;82:110-22.
-
(2001)
J Cell Biochem
, vol.82
, pp. 110-122
-
-
Shah, S.A.1
Potter, M.W.2
McDade, T.P.3
-
29
-
-
0034902354
-
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
-
Sunwoo JB, Chen Z, Dong G, et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 2001;7:1419-28.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1419-1428
-
-
Sunwoo, J.B.1
Chen, Z.2
Dong, G.3
-
30
-
-
0033817518
-
Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341
-
Frankel A, Man S, Elliott P, Adams J, Kerbel RS. Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res 2000;6:3719-28.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3719-3728
-
-
Frankel, A.1
Man, S.2
Elliott, P.3
Adams, J.4
Kerbel, R.S.5
-
31
-
-
0032885416
-
The proteasome inhibitor PS-341 in cancer therapy
-
Teicher BA, Ara G, Herbst R, Palombella VJ, Adams J. The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res 1999;5:2638-45.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2638-2645
-
-
Teicher, B.A.1
Ara, G.2
Herbst, R.3
Palombella, V.J.4
Adams, J.5
-
32
-
-
0035328584
-
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
-
Cusack JC, Jr., Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res 2001;61:3535-40.
-
(2001)
Cancer Res
, vol.61
, pp. 3535-3540
-
-
Cusack Jr., J.C.1
Liu, R.2
Houston, M.3
-
33
-
-
27144435616
-
PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: A North Central Cancer Treatment Group (NCCTG) randomized phase II study
-
Alberts SR, Foster NR, Morton RF, et al. PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study. Ann Oncol 2005;16:1654-61.
-
(2005)
Ann Oncol
, vol.16
, pp. 1654-1661
-
-
Alberts, S.R.1
Foster, N.R.2
Morton, R.F.3
-
34
-
-
39649096284
-
Transfection with CD40L induces tumor suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma
-
Serba S, Schmidt J, Wentzensen N, Ryschich E, Märten A. Transfection with CD40L induces tumor suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma. Gut 2008;57:344-51.
-
(2008)
Gut
, vol.57
, pp. 344-351
-
-
Serba, S.1
Schmidt, J.2
Wentzensen, N.3
Ryschich, E.4
Märten, A.5
-
35
-
-
0023879793
-
Interspecific scalingof toxicity data
-
Travis CC, White RK. Interspecific scalingof toxicity data. Risk Anal 1988;8:119-25.
-
(1988)
Risk Anal
, vol.8
, pp. 119-125
-
-
Travis, C.C.1
White, R.K.2
-
36
-
-
0025137091
-
Interspecies extrapolation of pharmacokinetics
-
Travis CC, White RK, Ward RC. Interspecies extrapolation of pharmacokinetics. J Theor Biol 1990;142:285-304.
-
(1990)
J Theor Biol
, vol.142
, pp. 285-304
-
-
Travis, C.C.1
White, R.K.2
Ward, R.C.3
-
37
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris 3rd, H.A.1
Moore, M.J.2
Andersen, J.3
-
38
-
-
56249149392
-
-
Cunningham D, Chau I, Stocken D, et al. Phase III randomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreatic cancer. Eur J Cancer 2005;4:abstract PS11.
-
Cunningham D, Chau I, Stocken D, et al. Phase III randomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreatic cancer. Eur J Cancer 2005;4:abstract PS11.
-
-
-
-
39
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-6.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
40
-
-
39149105933
-
Unusual discordant responses in two multiple myeloma patients during bortezomib treatment
-
Pirrotta MT, Gozzetti A, Cerase A, et al. Unusual discordant responses in two multiple myeloma patients during bortezomib treatment. Onkologie 2008;31:45-7.
-
(2008)
Onkologie
, vol.31
, pp. 45-47
-
-
Pirrotta, M.T.1
Gozzetti, A.2
Cerase, A.3
-
41
-
-
0042235056
-
Schedule-dependent molecular effects of the proteasome inhibitor bortezomib and gemcitabine in pancreatic cancer
-
Fahy BN, Schlieman MG, Virudachalam S, Bold RJ. Schedule-dependent molecular effects of the proteasome inhibitor bortezomib and gemcitabine in pancreatic cancer. J Surg Res 2003;113:88-95.
-
(2003)
J Surg Res
, vol.113
, pp. 88-95
-
-
Fahy, B.N.1
Schlieman, M.G.2
Virudachalam, S.3
Bold, R.J.4
-
42
-
-
33847023140
-
Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting
-
Dewhirst MW. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res 2007;67:854-5.
-
(2007)
Cancer Res
, vol.67
, pp. 854-855
-
-
Dewhirst, M.W.1
-
43
-
-
12844255716
-
Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
-
Berger M, Bergers G, Arnold B, Hammerling GJ, Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood 2005;105:1094-101.
-
(2005)
Blood
, vol.105
, pp. 1094-1101
-
-
Berger, M.1
Bergers, G.2
Arnold, B.3
Hammerling, G.J.4
Ganss, R.5
-
44
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
45
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw B, Song H, Tihan T, et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003;4:133-46.
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
Song, H.2
Tihan, T.3
|