Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6711-6724

  Manam, Rama Rao ^a   McArthur, Katherine A ^a   Chao, Ta Hsiang ^a   Weiss, Jeffrey ^a   Ali, Janid A ^b   Palombella, Vito J ^b   Groll, Michael ^c   Lloyd, G Kenneth ^a   Palladino, Michael A ^a   Neuteboom, Saskia T C ^a   Macherla, Venkat R ^a   Potts, Barbara C M ^a  

^a Nereus Pharmaceuticals Inc   (United States)

^b Infinity Pharmaceuticals Inc   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOSALINOSPORAMIDE; CASPASE; CHYMOTRYPSIN; FLUOROSALINOSPARAMIDE; HYDROXYSALINOSPORAMIDE; IODOSALINOSPORAMIDE; PROTEASOME; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; SALINOSPORAMIDE B; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; DIALYSIS; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN;

ANIMALS; ENZYME INHIBITORS; HYDROLYSIS; KINETICS; LACTAMS; LACTONES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; PYRROLES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56249111355     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800548b     Document Type: Article

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