Cell fusion is a physiological process in mouse liver

Hepatology

Volumn 48, Issue 5, 2008, Pages 1655-1664

  Faggioli, Francesca ^a,b   Sacco, Maria Grazia ^a,c   Susani, Lucia ^a,b   Montagna, Cristina ^d   Vezzoni, Paolo ^a,b  

^a CNR   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c JOINT RESEARCH CENTRE   (Italy)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CELL FUSION; CHROMOSOME ANALYSIS; CHROMOSOME PAINTING; CONTROLLED STUDY; CYTOLOGY; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER METABOLISM; MOLECULAR PROBE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; X CHROMOSOME; Y CHROMOSOME; ANIMAL; C57BL MOUSE; CHIMERA; DNA REPLICATION; GENE AMPLIFICATION; GENETIC MARKER; GENETICS; LIVER; LIVER CIRCULATION; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BETA-GALACTOSIDASE; CELL FUSION; CHIMERA; DNA; DNA REPLICATION; GENE AMPLIFICATION; GENES, REPORTER; GENETIC MARKERS; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER; LIVER CIRCULATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION;

EID: 56149095964     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22488     Document Type: Article

References (40)

1. Brodsky WY, Uryvaeva IV. Cell polyploidy: Its relation to tissue growth and function. Int Rev Cyt 1977;50:275-332.
2. Mintz B. Gene control of mammalian differentiation. Annu Rev Genet 1974;8:411-470.
3. Gupta S. Hepatic polyploidy and liver growth control. Sem Cancer Biol 2000;10:161-171.
4. Theise ND, Wilmut I. Cell plasticity: Flexible arrangement. Nature 2003; 425:21.
5. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003;102:3483-3493.
6. Wagers A, Weissman I. Plasticity of adult stem cells. Cell 2004;116:639-648.
7. Vassilopoulos G, Russell DW. Cell fusion: An alternative to stem cell plasticity and its therapeutic implications. Curr Opin Genet Dev 2003;13: 480-485.
8. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-1234.
9. Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 2004;6:532-539.
10. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003;425:968-973.
11. Kanazawa Y, Verma IM. Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A 2003; 100(Suppl 1):11850-11853.
12. Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003;422,823-825.
13. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
14. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297:2256-2259.
15. Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, et al. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med 2004;10:744-748.
16. Quintana-Bustamante O, Alvarez-Barrientos A, Kofman AV, Fabregat I, Bueren JA, Theise ND, et al. Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion. HEPATOLOGY 2006;43:108-116.
17. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377
18. Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest 2004;113:1266-1270.
19. Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 2004;305:90-93.
20. Chamberlain J, Yamagami T, Colletti E, Theise ND, Desai J, Frias A, et al. Efficient generation of human hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep. HEPATOLOGY 2007; 46:1935-1945.
21. Cogle CR, Theise ND, Fu D, Ucar D, Lee S, Guthrie SM, et al. Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem Cells 2007;25:1881-1887.
22. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005;106:756-763.
23. Theise ND, Krause DS, Sharkis S. Comment on "Little evidence for developmental plasticity of adult hematopoietic stem cells." Science 2003; 299:1317.
24. Herzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, et al. Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. FASEB J 2007;21:2592-2601.
25. Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, et al. Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A 2006;103:6321-6325.
26. Nygren JM, Jovinge S, Breitbach M, Säwén P, Röll W, Hescheler J, et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004;10:494-501.
27. Mintz B. Formation of genotypically mosaic mouse embryos. Am Zool 1962;2:432.
28. Mintz B. Genetic mosaicism in adult mice of quadriparental lineage. Science 1965;148:1232-1233.
29. Mintz B, Baker WW. Normal mammalian muscle differentiation and gene control of isocitrate dehydrogenase synthesis. Proc Natl Acad Sci U S A 1967;58:592-598.
30. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. "Green mice" as a source of ubiquitous green cells. FEBS Lett 1997; 407:313-319.
31. Friedrich G, Soriano P. Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes Dev 1991;5:1513-1523.
32. Hogan B, Beddington R, Costantini F, Lacy E. Manipulating the Mouse Embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1994.
33. Clerici L, Sacco MG, Merlini M. Acetaldehyde activation of poly(ADP-ribose) polymerase in hepatocytes of mice treated in vivo. Mutat Res 1989; 227:47-51.
34. Ogle BM, Cascalho M, Platt JL. Biological implications of cell fusion. Nat Rev Mol Cell Biol 2005;6:567-575.
35. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science 2003;299:363.
36. Guidotti JE, Brégerie O, Robert A, Debey P, Brechot C, Desdouets C. Liver cell polyploidization: A pivotal role for binuclear hepatocytes. J Biol Chem 2003;23:19095-19101.
37. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416:542-545.
38. Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature 2002;416:545-548.
39. Weimann JM, Johansson CB, Trejo A, Blau HM. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol 2003;5:959-966.
40. Magrassi L, Grimaldi P, Ibatici A, Corselli M, Ciardelli L, Castello S, et al. Induction and survival of binucleated Purkinje neurons by selective damage and aging. J. Neurosci 2007;27:9885-9892.