Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation

FASEB Journal

Volumn 21, Issue 10, 2007, Pages 2592-2601

  Herzog, Erica L ^a   Van Arnam, John ^a   Hu, Buqu ^a   Zhang, Jason ^a   Chen, Qingsheng ^a   Haberman, Ann M ^a   Krause, Diane S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fusion; Plasticity

Indexed keywords

SURFACTANT PROTEIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CHROMOSOME LOSS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HETEROKARYON; LUNG ALVEOLUS CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; Y CHROMOSOME;

ANIMALS; BONE MARROW TRANSPLANTATION; CHROMOSOME DELETION; FEMALE; INFLAMMATION; MALE; MICE; MICE, KNOCKOUT; PEPTIDES; POSTOPERATIVE COMPLICATIONS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; WHOLE-BODY IRRADIATION; Y CHROMOSOME;

MURINAE; MUS;

EID: 34547748468     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7861com     Document Type: Article

References (31)

1. Herzog, E. L., Chai, L., and Krause, D. S. (2003) Plasticity of marrow-derived stem cells. Blood 102, 3483-3493
2. Weimann, J. M., Johansson, C. B., Trejo, A., and Blau, H. M. (2003) Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat. Cell Biol. 5, 959-966
3. Alvarez-Dolado, M. P. R., Garcia-Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., and Alvarez-Buylla, A. (2003) Fusion of bone marrow derived cells with purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973
4. Wang, X., Willenbring, H., Akkari, Y., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M., Olson, S., and Grompe, M. (2003) Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422, 897-901
5. Vassilopoulos, G., Wang, P. R., and Russell, D. W. (2003) Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901-904
6. Sacco, A., Doyonnas, R., LaBarge, M. A., Hammer, M. M., Kraft, P., and Blau, H. M. (2005) IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors. J. Cell Biol. 171, 483-492
7. Rizvi, A. Z., Swain, J. R., Davies, P. S., Bailey, A. S., Decker, A. D., Willenbring, H., Grompe, M., Fleming, W. H., and Wong, M. H. (2006) Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc. Natl. Acad. Sci. U. S. A. 103, 6321-6325
8. Held, P. K., Al-Dhalimy, M., Willenbring, H., Akkari, Y., Jiang, S., Torimaru, Y., Olson, S., Fleming, W. H., Finegold, M., and Grompe, M. (2006) In vivo genetic selection of renal proximal tubules. Mol. Ther. 13, 49-58
9. Harris, R. G., Herzog, E. L., Bruscia, E. M., Grove, J. E., Van Arnam, J. S., and Krause, D. S. (2004) Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 305, 90-93
10. Herzog, E. L., Van Arnam, J., Hu, B., and Krause, D. S. (2006) Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24, 1986-1992
11. Theise N. D., Henegariou, O., Grove J., Jagirdar J., Kao P., Crawford J., Badve S., Saxena R., and Krause, D. (2002) Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. J. Exp. Hem.
12. Gomperts, B. N., Belperio, J. A., Rao, P. N., Randell, S. H., Fishbein, M. C., Burdick, M. D., and Strieter, R. M. (2006) Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J. Immunol. 176, 1916-1927
13. Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T., and Sasaki, H. (2004) Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J. Immunol. 172, 1266-1272
14. Loi, R., Beckett, T., Goncz, K. K., Suratt, B. T., and Weiss, D. J. (2006) Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am. J. Respir. Crit. Care Med. 173, 171-179
15. Macpherson, H., Keir, P., Webb, S., Samuel, K., Boyle, S., Bickmore, W., Forrester, L., and Dorin, J. (2005) Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo. J. Cell Sci. 118, 2441-2450
16. Glasser, S. W., Detmer, E. A., Ikegami, M., Na, C. L., Stahlman, M. T., and Whitsett, J. A. (2003) Pneumonitis and emphysema in sp-C gene targeted mice. J. Biol. Chem. 278, 14291-14298
17. Wang, Z., Zheng, T., Zhu, Z., Homer, R. J., Riese, R. J., Chapman, H. A., Jr., Shapiro, S. D., and Elias, J. A. (2000) Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 192, 1587-1600
18. Jentsch, I. A. I., Carter, N., and Speicher, M. (2001) Karyotyping mouse chromosomes by multiplex-FISH (M-FISH). Chromosome Res. 9, 211-214
19. Summer, R., Kotton, D. N., Sun, X., Fitzsimmons, K., and Fine, A. (2004) Transitional physiology: origin and phenotype of lung side population cells. Am. J. Physiol. 287, L477-L483
20. Bourbon, J. R., and Chailley-Heu, B. (2001) Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance. Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 129, 151-161
21. Di, A., Brown, M. E., Deriy, L. V., Li, C., Szeto, F. L., Chen, Y., Huang, P., Tong, J., Naren, A. P., Bindokas, V., Palfrey, H. C., and Nelson, D. J. (2006) CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat. Cell Biol. 8, 933-944
22. Chang, J. C., Summer, R., Sun, X., Fitzsimmons, K., and Fine, A. (2005) Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am. J. Respir. Cell Mol. Biol. 33, 335-342
23. Kotton, D. N., Fabian, A. J., and Mulligan, R. C. (2005) Failure of bone marrow to reconstitute lung epithelium. Am. J. Respir. Cell Mol. Biol. 33, 328-334
24. Nogee, L. M., Dunbar, A. E., 3rd, Wert, S. E., Askin, F., Hamvas, A., and Whitsett, J. A. (2001) A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N. Engl. J. Med. 344, 573-579
25. Perl, A. K., Wert, S. E., Nagy, A., Lobe, C. G., and Whitsett, J. A. (2002) Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc. Natl. Acad. Sci. U. S. A. 99, 10482-10487
26. Kim, C. F., Jackson, E. L., Woolfenden, A. E., Lawrence, S., Babar, I., Vogel, S., Crowley, D., Bronson, R. T., and Jacks, T. (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823-835
27. Palermo, A. T., Labarge, M. A., Doyonnas, R., Pomerantz, J., and Blau, H. M. (2005) Bone marrow contribution to skeletal muscle: a physiological response to stress. Dev. Biol. 279, 336-344
28. Weimann, J. M., Charlton, C. A., Brazelton, T. R., Hackman, R. C., and Blau, H. M. (2003) Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Natl. Acad. Sci. U. S. A. 100, 2088-2093
29. LaBarge, M. A., and Blau, H. M. (2002) Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111, 589-601
30. Andrade, J., Lam, J. T., Zamora, M., Huang, C., Franco, D., Sevilla, N., Gruber, P. J., Lu, J. T., and Ruiz-Lozano, P. (2005) Predominant fusion of bone marrow-derived cardiomyocytes. Cardiovasc. Res. 68, 387-393
31. Lee, C. G., Cho, S., Homer, R. J., and Elias, J. A. (2006) Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proc. Am. Thorac. Soc. 3, 476-477