메뉴 건너뛰기




Volumn 181, Issue 6, 2008, Pages 4150-4158

Characterization of T cell responses to the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis in BALB/c mice

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ALANINE; ALANYLASPARAGINYLGLYCYLLEUCYLALANYLALANYLTHREONYLHISTIDYL ALANYLGLYCYLASPARAGINYLISOLEUCYLGLYCYLASPARAGINYLISOLEUCINE; ALANYLASPARAGINYLTYROSYLTHREONYLALANYLHISTIDYLGLYCYLSERYL GLUTAMYLTHREONYLALANYLTRYPTOPHYLALANYLASPARTYLPROLINE; ALANYLPHENYLALANYLISOLEUCYLHISTIDYLLYSYLLYSYLTYROSYL ASPARAGINYLASPARTYLGLYCYLLEUCYLALANYLALANYLSERYLALANINE; ALANYLSERYLLEUCYLPROLYLGLUTAMINYLASPARAGINYLGLUTAMINYL ALANYLSERYLTYROSYLSERYLISOLEUCYLGLUTAMINYLALANYLSERINE; ALANYLTRYPTOPHYLALANYLASPARTYLPROLYLLEUCYLLEUCYLTHREONYL THREONYLSERYLGLUTAMINYLLEUCYLLYSYLALANYLLEUCINE; ARGINYLGLYCYLPROLYLALANINE LYSYLGLYCYLPROLINE; ASPARAGINYLTYROSYLLEUCYLLYSYLALANYLPROLYLTYROSYLTHREONYL GLYCYLCYSTEINYLTYROSYLSERYLHISTIDYLLEUCYLASPARAGINE; ASPARTYLVALYLALANYLCYSTEINYLVALYLASPARAGINYLGLYCYL ASPARTYLPHENYLALANYLLEUCYLPHENYLALANYLSERYLMETHIONYLPROLYLCYSTEINE; EPITOPE; GAMMA INTERFERON; GLUTAMIC ACID; GLUTAMYLLYSYLVALYLLEUCYLLEUCYLISOLEUCYLALANYLGLYCYLALANYL ASPARTYLTYROSYLSERYLTRYPTOPHYLASPARAGINYLSERINE; GLYCYLASPARTYLGLYCYLSERYLVALYLMETHIONYLPROLYLTYROSYLARGINYL ALANYLMETHIONYLPROLYLLYSYLTHREONYLASPARAGINE; GLYCYLGLUTAMYLLYSYLGLYCYLLYSYLLYSYLTHREONYLLYSYLLYSYLVALYL THREONYLASPARTYLLEUCYLTYROSYLTYROSINE; HISTIDINE; INTERLEUKIN 4; LYSYLALANYLTHREONYLMETHIONYLPROLYLASPARTYLLYSYLSERYLTYROSYLL EUCYLGLUTAMYLLYSYLVALYLLEUCYLLEUCINE; LYSYLGLYCYLALANYLTYROSYLALANYLTYROSYLISOLEUCYLGLYCYLSERYL SERYLPROLYLASPARAGINYLSERYLTYROSYLTRYPTOPHAN; PHENYLALANYLGLYCYLGLUTAMYLVALYLISOLEUCYLTHREONYLARGINYLVALYLLYSYL GLUTAMYLLYSYLGLYCYLALANYLTYROSYLALANINE; POLYMER; PROTEINASE; SERYLHISTIDYLLEUCYLASPARAGINYLTHREONYLGLYCYLVALYLSERYLPHENYL ALANYLALANYLASPARAGINYLTYROSYLTHREONYLALANINE; SERYLISOLEUCYLGLUTAMINYLALANYLSERYLALANYLGLYCYLSERYL TYROSYLVALYLALANYLISOLEUCYLSERYLLYSYLASPARTIC ACID; SYNTHETIC PEPTIDE; THREONYLASPARAGINYLSERYLASPARAGINYLGLUTAMINYLL EUCYLPROLYLPHENYLALANYLISOLEUCYLPHENYLALANYLASPARTYLVALYLALANYLCYSTEINYLVALINE; THREONYLISOLEUCYLLYSYLTYROSYLGLYCYLMETHIONYLGLUTAMINYL TYROSYLTYROSYLTYROSYLASPARAGINYLGLUTAMINYLGLUTAMYLHISTIDYLGLYCINE; TRYPTOPHAN; TYROSYLSERYLTRYPTOPHYLASPARAGINYLSERYLGLUTAMINYLVALYLGLYCYL GLUTAMINYLPROLYLTHREONYLISOLEUCYLLYSYLTYROSYLGLYCINE; UNCLASSIFIED DRUG; ARGINGIPAIN, PORPHYROMONAS GINGIVALIS; CYSTEINE PROTEINASE; LYS GINGIPAIN; LYS-GINGIPAIN; PEPTIDE FRAGMENT;

EID: 56149088041     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.6.4150     Document Type: Article
Times cited : (9)

References (54)
  • 1
    • 0031992463 scopus 로고    scopus 로고
    • Periodontal Diseases in the United States Population
    • Oliver, R. C., L. J. Brown, and H. Loe. 1998. Periodontal diseases in the United States population. J. Periodontol. 69: 269-278. (Pubitemid 128518357)
    • (1998) Journal of Periodontology , vol.69 , Issue.2 , pp. 269-278
    • Oliver, R.C.1    Brown, L.J.2    Loe, H.3
  • 3
    • 0019464127 scopus 로고
    • Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): Relationship to age and periodontal disease
    • Mouton, C., P. G. Hammond, J. Slots, and R. J. Genco. 1981. Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease. Infect. Immun. 31: 182-192. (Pubitemid 11136072)
    • (1981) Infection and Immunity , vol.31 , Issue.1 , pp. 182-192
    • Mouton, C.1    Hammond, P.G.2    Slots, J.3    Genco, R.J.4
  • 4
    • 0023409676 scopus 로고
    • Microbiology of periodontal disease
    • Moore, W. E. 1987. Microbiology of periodontal disease. J. Periodontal Res. 22: 335-341.
    • (1987) J. Periodontal Res. , vol.22 , pp. 335-341
    • Moore, W.E.1
  • 5
    • 0021403590 scopus 로고
    • Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: Virulence factors in colonization, survival, and tissue destruction
    • Slots, J., and R. J. Genco. 1984. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J. Dent. Res. 63: 412-421.
    • (1984) J. Dent. Res. , vol.63 , pp. 412-421
    • Slots, J.1    Genco, R.J.2
  • 6
    • 0026248171 scopus 로고
    • Relation of counts of microbial species to clinical status at the sampled site
    • Socransky, S. S., A. D. Haffajee, C. Smith, and S. Dibart. 1991. Relation of counts of microbial species to clinical status at the sampled site. J. Clin. Periodontol. 18: 766-775.
    • (1991) J. Clin. Periodontol. , vol.18 , pp. 766-775
    • Socransky, S.S.1    Haffajee, A.D.2    Smith, C.3    Dibart, S.4
  • 7
    • 0345621675 scopus 로고    scopus 로고
    • Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis-induced alveolar bone loss in mice
    • Baker, P. J., S. Carter, M. Dixon, R. T. Evans, and D. C. Roopenian. 1999. Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis-induced alveolar bone loss in mice. Oral Microbiol. Immunol. 14: 194-196.
    • (1999) Oral Microbiol. Immunol. , vol.14 , pp. 194-196
    • Baker, P.J.1    Carter, S.2    Dixon, M.3    Evans, R.T.4    Roopenian, D.C.5
  • 8
    • 24744447203 scopus 로고    scopus 로고
    • An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss
    • O'Brien-Simpson, N. M., R. D. Pathirana, R. A. Paolini, Y.-Y. Chen, P. D. Veith, V. Tam, N. Ally, R. N. Pike, and E. C. Reynolds. 2005. An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss. J. Immunol. 175: 3980-3989.
    • (2005) J. Immunol. , vol.175 , pp. 3980-3989
    • O'Brien-Simpson, N.M.1    Pathirana, R.D.2    Paolini, R.A.3    Chen, Y.-Y.4    Veith, P.D.5    Tam, V.6    Ally, N.7    Pike, R.N.8    Reynolds, E.C.9
  • 9
    • 0036117913 scopus 로고    scopus 로고
    • Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model
    • Rajapakse, P. S., N. M. O'Brien-Simpson, N. Slakeski, B. Hoffmann, and E. C. Reynolds. 2002. Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model Infect. Immun. 70: 2480-2486.
    • (2002) Infect. Immun. , vol.70 , pp. 2480-2486
    • Rajapakse, P.S.1    O'Brien-Simpson, N.M.2    Slakeski, N.3    Hoffmann, B.4    Reynolds, E.C.5
  • 11
    • 0028031966 scopus 로고
    • Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates
    • Persson, G. R., D. Engel, C. Whitney, R. Darveau, A. Weinberg, M. Brunsvold, and R. C. Page. 1994. Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect. Immun. 62: 1026-1031.
    • (1994) Infect. Immun. , vol.62 , pp. 1026-1031
    • Persson, G.R.1    Engel, D.2    Whitney, C.3    Darveau, R.4    Weinberg, A.5    Brunsvold, M.6    Page, R.C.7
  • 12
    • 0023847614 scopus 로고
    • Biology of asaccharolytic black-pigmented Bacteroides species
    • Mayrand, D., and S. C. Holt. 1988. Biology of asaccharolytic black-pigmented Bacteroides species. Microbiol. Rev. 52: 134-152. (Pubitemid 18083343)
    • (1988) Microbiological Reviews , vol.52 , Issue.1 , pp. 134-152
    • Mayrand, D.1    Holt, S.C.2
  • 13
    • 0025968113 scopus 로고
    • Porphyromonas (Bacteroides) gingivalis fimbrillin: Size, amino-terminal sequence, and antigenic heterogeneity
    • Lee, J. Y., H. T. Sojar, G. S. Bedi, and R. J. Genco. 1991. Porphyromonas (Bacteroides) gingivalis fimbrillin: size, amino-terminal sequence, and antigenic heterogeneity. Infect. Immun. 59: 383-389.
    • (1991) Infect. Immun. , vol.59 , pp. 383-389
    • Lee, J.Y.1    Sojar, H.T.2    Bedi, G.S.3    Genco, R.J.4
  • 14
    • 0029936655 scopus 로고    scopus 로고
    • Trypsin-like protease activity of Porphyromonas gingivalis as a potential virulence factor in a murine lesion model
    • DOI 10.1006/mpat.1996.0001
    • Kesavalu, L., S. C. Holt, and J. L. Ebersole. 1996. Trypsin-like protease activity of Porphyromonas gingivalis as a potential virulence factor in a murine lesion model. Microb. Pathog. 20: 1-10. (Pubitemid 26150070)
    • (1996) Microbial Pathogenesis , vol.20 , Issue.1 , pp. 1-10
    • Kesavalu, L.1    Holt, S.C.2    Ebersole, J.L.3
  • 15
    • 0037261991 scopus 로고    scopus 로고
    • The role of gingipains in the pathogenesis of periodontal disease
    • DOI 10.1902/jop.2003.74.1.111
    • Imamura, T. 2003. The role of gingipains in the pathogenesis of periodontal disease. J. Periodont. 74: 111-118. (Pubitemid 36175742)
    • (2003) Journal of Periodontology , vol.74 , Issue.1 , pp. 111-118
    • Imamura, T.1
  • 16
    • 0344825092 scopus 로고    scopus 로고
    • Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: Structure, function and assembly of multidomain protein complexes
    • DOI 10.2174/1389203033487036
    • Potempa, J., A. Sroka, T. Imamura, and J. Travis. 2003. Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes. Curr. Protein Pept. Sci. 4: 397-407. (Pubitemid 37455910)
    • (2003) Current Protein and Peptide Science , vol.4 , Issue.6 , pp. 397-407
    • Potempa, J.1    Sroka, A.2    Imamura, T.3    Travis, J.4
  • 18
    • 0030737648 scopus 로고    scopus 로고
    • A cell-associated protein complex of Porphyromonas gingivalis W50 composed of Arg- And Lys-specific cysteine proteinases and adhesins
    • Bhogal, P. S., N. Slakeski, and E. C. Reynolds. 1997. A cell-associated protein complex of Porphyromonas gingivalis W50 composed of Arg- and Lys-specific cysteine proteinases and adhesins. Microbiology 143: 2485-2495.
    • (1997) Microbiology , vol.143 , pp. 2485-2495
    • Bhogal, P.S.1    Slakeski, N.2    Reynolds, E.C.3
  • 19
    • 0036533761 scopus 로고    scopus 로고
    • Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50
    • Veith, P. D., G. H. Talbo, N. Slakeski, S. G. Dashper, C. Moore, R. A. Paolini, and E. C. Reynolds. 2002. Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50. Biochem. J. 363: 105-115.
    • (2002) Biochem. J. , vol.363 , pp. 105-115
    • Veith, P.D.1    Talbo, G.H.2    Slakeski, N.3    Dashper, S.G.4    Moore, C.5    Paolini, R.A.6    Reynolds, E.C.7
  • 20
    • 0030601241 scopus 로고    scopus 로고
    • Characterization of a porphyromonas gingivalis gene prtR that encodes an arginine-specific thiol proteinase and multiple adhesins
    • DOI 10.1006/bbrc.1996.1073
    • Slakeski, N., S. M. Cleal, and E. C. Reynolds. 1996. Characterization of a Porphyromonas gingivalis gene prtR that encodes an arginine-specific thiol proteinase and multiple adhesins. Biochem. Biophys. Res. Commun. 224: 605-610. (Pubitemid 26278635)
    • (1996) Biochemical and Biophysical Research Communications , vol.224 , Issue.3 , pp. 605-610
    • Slakeski, N.1    Cleal, S.M.2    Reynolds, E.C.3
  • 21
    • 0033121176 scopus 로고    scopus 로고
    • Characterization of a Porphyromonas gingivalis gene prtK that encodes a lysine-specific cysteine proteinase and three sequence-related adhesins
    • DOI 10.1034/j.1399-302X.1999.140203.x
    • Slakeski, N., S. M. Cleal, P. S. Bhogal, and E. C. Reynolds. 1999. Characterization of a Porphyromonas gingivalis gene prtK that encodes a lysine-specific cysteine proteinase and three sequence-related adhesins. Oral Microbiol. Immunol. 14: 92-97. (Pubitemid 29130848)
    • (1999) Oral Microbiology and Immunology , vol.14 , Issue.2 , pp. 92-97
    • Slakeski, N.1    Cleal, S.M.2    Bhogal, P.S.3    Reynolds, E.C.4
  • 22
    • 0035192014 scopus 로고    scopus 로고
    • Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model
    • O'Brien-Simpson, N. M., R. A. Paolini, B. Hoffmann, N. Slakeski, S. G. Dashper, and E. C. Reynolds. 2001. Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model. Infect. Immun. 69: 7527-7534.
    • (2001) Infect. Immun. , vol.69 , pp. 7527-7534
    • O'Brien-Simpson, N.M.1    Paolini, R.A.2    Hoffmann, B.3    Slakeski, N.4    Dashper, S.G.5    Reynolds, E.C.6
  • 24
    • 0033932230 scopus 로고    scopus 로고
    • RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model
    • O'Brien-Simpson, N. M., R. A. Paolini, and E. C. Reynolds. 2000. RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model. Infect. Immun. 68: 4055-4063.
    • (2000) Infect. Immun. , vol.68 , pp. 4055-4063
    • O'Brien-Simpson, N.M.1    Paolini, R.A.2    Reynolds, E.C.3
  • 25
    • 0034103532 scopus 로고    scopus 로고
    • Serum immunoglobulin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis
    • O'Brien-Simpson, N. M., C. L. Black, P. S. Bhogal, S. M. Cleal, N. Slakeski, T. J. Higgins, and E. C. Reynolds. 2000. Serum immunoglobulin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis. Infect. Immun. 68: 2704-2712.
    • (2000) Infect. Immun. , vol.68 , pp. 2704-2712
    • O'Brien-Simpson, N.M.1    Black, C.L.2    Bhogal, P.S.3    Cleal, S.M.4    Slakeski, N.5    Higgins, T.J.6    Reynolds, E.C.7
  • 28
    • 0035432824 scopus 로고    scopus 로고
    • T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis
    • Baker, P. J., J. Garneau, L. Howe, and D. C. Roopenian. 2001. T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis. Acta Odontol. Scand. 59: 222-225.
    • (2001) Acta Odontol. Scand. , vol.59 , pp. 222-225
    • Baker, P.J.1    Garneau, J.2    Howe, L.3    Roopenian, D.C.4
  • 29
    • 8744277930 scopus 로고    scopus 로고
    • The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss
    • DOI 10.1111/j.1600-0765.2004.00760.x
    • Sasaki, H., Y. Okamatsu, T. Kawai, R. Kent, M. Taubman, and P. Stashenko. 2004. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J. Periodontal Res. 39: 432-441. (Pubitemid 39523888)
    • (2004) Journal of Periodontal Research , vol.39 , Issue.6 , pp. 432-441
    • Sasaki, H.1    Okamatsu, Y.2    Kawai, T.3    Kent, R.4    Taubman, M.5    Stashenko, P.6
  • 31
    • 0015180973 scopus 로고
    • The biochemical properties and antibiotic susceptibility of Bacteroides melaninogenicus
    • Werner, H., G. Pulverer, and C. Reichert. 1971. The biochemical properties and antibiotic susceptibility of Bacteroides melaninogenicus. Med. Microbiol. Immunol. 157: 3-9.
    • (1971) Med. Microbiol. Immunol. , vol.157 , pp. 3-9
    • Werner, H.1    Pulverer, G.2    Reichert, C.3
  • 32
    • 0031036570 scopus 로고    scopus 로고
    • The prpR1 and prR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes
    • Rangarajan, M., J. AduseOpoku, J. M. Slaney, K. A. Young, and M. A. Curtis. 1997. The prpR1 and prR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes. Mol. Microbiol. 23: 955-965. (Pubitemid 27096731)
    • (1997) Molecular Microbiology , vol.23 , Issue.5 , pp. 955-965
    • Rangarajan, M.1    Aduse-Opoku, J.2    Slaney, J.M.3    Young, K.A.4    Curtis, M.A.5
  • 33
    • 0033870895 scopus 로고    scopus 로고
    • Generation of Lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities
    • Aduse-Opoku, J., N. N. Davies, A. Gallagher, A. Hashim, H. E. A. Evans, M. Rangarajan, J. M. Slaney, and M. A. Curtis. 2000. Generation of Lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arggingipain protease activities. Microbiology 146: 1933-1940. (Pubitemid 30639268)
    • (2000) Microbiology , vol.146 , Issue.8 , pp. 1933-1940
    • Aduse-Opoku, J.1    Davies, N.N.2    Gallagher, A.3    Hashim, A.4    Evans, H.E.A.5    Rangarajan, M.6    Slaney, J.M.7    Curtis, M.A.8
  • 35
    • 33749435760 scopus 로고    scopus 로고
    • Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection
    • Frazer, L. T., N. M. O'Brien-Simpson, N. Slakeski, K. A. Walsh, P. D. Veith, C. G. Chen, I. G. Barr, and E. C. Reynolds. 2006. Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection. Vaccine 24: 6542-6565.
    • (2006) Vaccine , vol.24 , pp. 6542-6565
    • Frazer, L.T.1    O'Brien-Simpson, N.M.2    Slakeski, N.3    Walsh, K.A.4    Veith, P.D.5    Chen, C.G.6    Barr, I.G.7    Reynolds, E.C.8
  • 36
    • 0030988969 scopus 로고    scopus 로고
    • Polymerization of unprotected synthetic peptides: A view toward synthetic peptide vaccines
    • O'Brien-Simpson, N. M., N. J. Ede, L. E. Brown, J. Swan, and D. C. Jackson. 1997. Polymerization of unprotected synthetic peptides: a view toward synthetic peptide vaccines. J. Am. Chem. Soc. 119: 1183-1188.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 1183-1188
    • O'Brien-Simpson, N.M.1    Ede, N.J.2    Brown, L.E.3    Swan, J.4    Jackson, D.C.5
  • 39
    • 2142773262 scopus 로고    scopus 로고
    • Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: A possible mechanism of high dose tolerance
    • Michallet, M. C., F. Saltel, M. Flacher, J. P. Revillard, and L. Genestier. 2004. Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. J. Immunol. 172: 5405-5414.
    • (2004) J. Immunol. , vol.172 , pp. 5405-5414
    • Michallet, M.C.1    Saltel, F.2    Flacher, M.3    Revillard, J.P.4    Genestier, L.5
  • 40
  • 41
    • 0033118315 scopus 로고    scopus 로고
    • Induction of apoptosis in human gingival fibroblasts by a Porphyromonas gingivalis protease preparation
    • DOI 10.1016/S0003-9969(99)00002-3, PII S0003996999000023
    • Wang, P. L., S. Shirasu, M. Shinohara, M. Daito, M. Oido, Y. Kowashi, and K. Ohura. 1999. Induction of apoptosis in human gingival fibroblasts by a Porphyromonas gingivalis protease preparation. Arch. Oral Biol. 44: 337-342. (Pubitemid 29198182)
    • (1999) Archives of Oral Biology , vol.44 , Issue.4 , pp. 337-342
    • Wang, P.-L.1    Shirasu, S.2    Shinohara, M.3    Daito, M.4    Oido, M.5    Kowashi, Y.6    Ohura, K.7
  • 43
    • 33645105869 scopus 로고    scopus 로고
    • Porphyromonas gingivalis enhances FasL expression via up-regulation of NFκB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells
    • Brozovic, S., R. Sahoo, S. Barve, H. Shiba, S. Uriarte, R. S. Blumberg, and D. F. Kinane. 2006. Porphyromonas gingivalis enhances FasL expression via up-regulation of NFκB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells. Microbiology 152: 797-806.
    • (2006) Microbiology , vol.152 , pp. 797-806
    • Brozovic, S.1    Sahoo, R.2    Barve, S.3    Shiba, H.4    Uriarte, S.5    Blumberg, R.S.6    Kinane, D.F.7
  • 44
    • 28644452244 scopus 로고    scopus 로고
    • Immune response: The key to bone resorption in periodontal disease
    • Taubman, M. A., P. Valverde, X. Han, and T. Kawai. 2005. Immune response: the key to bone resorption in periodontal disease. J. Periodontol. 76: 2033-2041.
    • (2005) J. Periodontol. , vol.76 , pp. 2033-2041
    • Taubman, M.A.1    Valverde, P.2    Han, X.3    Kawai, T.4
  • 45
    • 1342323810 scopus 로고    scopus 로고
    • Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis
    • Nguyen, K.-A., A. A. DeCarlo, M. Paramaesvaran, C. A. Collyer, D. B. Langley, and N. Hunter. 2004. Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis. Infect. Immun. 72: 1374-1382.
    • (2004) Infect. Immun. , vol.72 , pp. 1374-1382
    • Nguyen, K.-A.1    DeCarlo, A.A.2    Paramaesvaran, M.3    Collyer, C.A.4    Langley, D.B.5    Hunter, N.6
  • 47
    • 0036857579 scopus 로고    scopus 로고
    • T-cell proliferation induced by local application of LPS in the nasal mucosa of nonatopic children
    • Tulic, M. K., J. J. Manoukian, D. H. Eidelman, and Q. Hamid. 2002. T-cell proliferation induced by local application of LPS in the nasal mucosa of nonatopic children. J. Allergy Clin. Immunol. 110: 771-776.
    • (2002) J. Allergy Clin. Immunol. , vol.110 , pp. 771-776
    • Tulic, M.K.1    Manoukian, J.J.2    Eidelman, D.H.3    Hamid, Q.4
  • 48
    • 0036681655 scopus 로고    scopus 로고
    • Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses
    • Ausiello, C. M., G. Fedele, F. Urbani, R. Lande, B. Di Carlo, and A. Cassone. 2002. Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses. J. Infect. Dis. 186: 351-360.
    • (2002) J. Infect. Dis. , vol.186 , pp. 351-360
    • Ausiello, C.M.1    Fedele, G.2    Urbani, F.3    Lande, R.4    Di Carlo, B.5    Cassone, A.6
  • 49
    • 0141504309 scopus 로고    scopus 로고
    • Epitope repertoire of Th1 and Th2 cells reactive with the mouse muscle AChR α subunit in C57B1/6 mice
    • DOI 10.1196/annals.1254.046
    • Wang, W., M. Milani, D. Okita, N. Ostlie, and B. M. Conti-Fine. 2003. Epitope repertoire of Th1 and Th2 cells reactive with the mouse muscle AChR α subunit in C57Bl/6 mice. Ann. NY Acad. Sci. 998: 384-387. (Pubitemid 37194185)
    • (2003) Annals of the New York Academy of Sciences , vol.998 , pp. 384-387
    • Wang, W.1    Milani, M.2    Okita, D.3    Ostlie, N.4    Conti-Fine, B.M.5
  • 50
    • 0344825091 scopus 로고    scopus 로고
    • Porphyromonas gingivalis gingipains: The molecular teeth of a microbial vampire
    • DOI 10.2174/1389203033487009
    • O'Brien-Simpson, N. M., P. D. Veith, S. G. Dashper, and E. C. Reynolds. 2003. Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire. Curr. Protein Pept. Sci. 4: 409-426. (Pubitemid 37455911)
    • (2003) Current Protein and Peptide Science , vol.4 , Issue.6 , pp. 409-426
    • O'Brien-Simpson, N.M.1    Veith, P.D.2    Dashper, S.G.3    Reynolds, E.C.4
  • 51
    • 0022358985 scopus 로고
    • Carrier-induced epitopic suppression, a major issue for future synthetic vaccines
    • Schutze, M. P., C. Leclerc, M. Jolivet, F. Audibert, and L. Chedid. 1985. Carrier-induced epitopic suppression, a major issue for future synthetic vaccines. J. Immunol. 135: 2319-2322.
    • (1985) J. Immunol. , vol.135 , pp. 2319-2322
    • Schutze, M.P.1    Leclerc, C.2    Jolivet, M.3    Audibert, F.4    Chedid, L.5
  • 52
    • 0027169876 scopus 로고
    • Determinants of release rate of tetanus vaccine from polyester microspheres
    • Alonso, M. J., S. Cohen, T. G. Park, R. K. Gupta, G. R. Siber, and R. Langer. 1993. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharm. Res. 10: 945-953.
    • (1993) Pharm. Res. , vol.10 , pp. 945-953
    • Alonso, M.J.1    Cohen, S.2    Park, T.G.3    Gupta, R.K.4    Siber, G.R.5    Langer, R.6
  • 53
    • 0028205133 scopus 로고
    • Biodegradable microspheres as controlled-release tetanus toxoid delivery systems
    • DOI 10.1016/0264-410X(94)90092-2
    • Alonso, M. J., R. K. Gupta, C. Min, G. R. Siber, and R. Langer. 1994. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine 12: 299-306. (Pubitemid 24071950)
    • (1994) Vaccine , vol.12 , Issue.4 , pp. 299-306
    • Alonso, M.J.1    Gupta, R.K.2    Min, C.3    Siber, G.R.4    Langer, R.5
  • 54
    • 33845198476 scopus 로고    scopus 로고
    • Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice
    • DOI 10.1016/j.vaccine.2006.09.036, PII S0264410X06010152
    • Mata, E., A. M. Carcaboso, R. M. Hernandez, M. Igartua, G. Corradin, and J. L. Pedraz. 2007. Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice. Vaccine 25: 877-885. (Pubitemid 44856124)
    • (2007) Vaccine , vol.25 , Issue.5 , pp. 877-885
    • Mata, E.1    Carcaboso, A.M.2    Hernandez, R.M.3    Igartua, M.4    Corradin, G.5    Pedraz, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.