Porphyromonas gingivalis enhance FasL expression via up-regulations if NFκB-mediated gene transcription and induces apoptopic cell death in human gingival epithelial cells

Microbiology

Volumn 152, Issue 3, 2006, Pages 797-806

  Brozovic, Suzana ^a,d   Sahoo, Rashmita ^b   Barve, Shirish ^b   Shiba, Hideki ^a   Uriarte, Silvia ^b   Blumberg, Richard S ^c   Kinane, Denis F ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF LOUISVILLE HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; FAS ANTIGEN; FAS LIGAND; HELENALIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; LUCIFERASE; MONOCLONAL ANTIBODY; SYNAPTOTAGMIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN; TLR2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EPITHELIUM CELL; GENETIC TRANSCRIPTION; GINGIVA; HEAT; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CYTOLOGY; METABOLISM; MICROBIOLOGY; PATHOGENICITY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PORPHYROMONAS GINGIVALIS;

APOPTOSIS; EPITHELIAL CELLS; FAS LIGAND PROTEIN; GINGIVA; HUMANS; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; PORPHYROMONAS GINGIVALIS; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTORS; UP-REGULATION;

EID: 33645105869     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.28472-0     Document Type: Article

References (36)

1. Alikhani, M., Alikhani, Z. & Graves, D. T. (2005). FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem 280, 12096-12102.
2. Asai, Y., Ohyama, Y., Gen, K. & Ogawa, T. (2001). Bacterial fimbriae and their peptides activate human gingival epithelial cells through toll-like receptor 2. Infect Immun 69, 7387-7395.
3. Asai, Y., Jinno, T. & Ogawa, T. (2003). Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2. Infect Immun 71, 717-725.
4. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. & Wallach, D. (1996). involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85, 803-815.
5. Chen, Y. & Zychlinsky, A. (1994). Apoptosis induced by bacterial pathogens. Microb Pathog 17, 203-212.
6. Chinnaiyan, A. M., O'Rourke, K., Tewari, M. & Dixit, V. M. (1995). FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-512.
7. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E. & Dixit, V. M. (1996). FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 271, 4961-4965.
8. Farhana, L., Dawson, M. J. & Fontana, J. A. (2005). Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-κB activation. Cancer Res 65, 4909-4917.
9. Gamonal, J., Bascones, A., Acevedo, A., Blanco, E. & Silva, A. (2001). Apoptosis in chronic adult periodontitis analyzed by in situ DNA breaks, electron microscopy, and immunohistochemistry. J Periodontol 72, 517-525.
10. Gregoli, P. A. & Bondurant, M. C. (1999). Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J Cell Physiol 178, 133-143.
11. Hsu, S.-C., Gavrilin, M. A., Lee, H.-H., Wu, C.-C., Han, S.-H. & Lai, M.-Z. (1999). NF-κB-dependent Fas ligand expression. Eur J Immunol 29, 2948-2956.
12. Kasumoto, Y., Hirano, H., Saitoh, K. & 10 other authors (2004). Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2. J Periodontol 75, 370-379.
13. Koulouri, O., Lappin, D. F., Radvar, M. & Kinane, D. F. (1999). Cell division, synthetic capacity and apoptosis in periodontal lesions analysed by in situ hybridisation and immunohistochemistry. J Clin Periodontol 26, 552-559.
14. Kuroshima, S., Sawa, Y., Kawamoto, T., Yamaoka, Y., Notani, K., Yoshida, S. & Inoue, N. (2004). Expression of Toll-like receptors 2 and 4 on human intestinal lymphatic vessels. Microvasc Res 67, 90-95.
15. Lash, L. H., Hueni, S. A. & Putt, D. A. (2001). Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. Toxicol Appl Pharmacol 177, 1-16.
16. Livak, K. J. & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and ΔΔCT method. Methods 25, 402-408.
17. Lyss, G., Knorre, A., Schmidt, T. J., Pahl, H. L. & Merfort, J. (1998). The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NFκB by directly targeting p65. J Biol Chem 273, 33508-33516.
18. McCloskey, T. W., Chavan, S., Lakshimi Tamma, S. M. & Pahwa, S. (1998). Comparison of seven quantitative assays to assess lymphocytic cell death during HIV infection: measurement of induced apoptosis in anti-Fas treated Jurkat cells and spontaneous apoptosis in peripheral blood mononuclear cells from children infected with HIV. AIDS Res Hum Retroviruses 14, 1413-1422.
19. Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H. & Peter, M. E. (1997). FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16, 2794-2804.
20. Nagata, S. (1997). Apoptosis by death factor. Cell 88, 355-365.
21. Nakhjiri, S. F., Park, Y., Yilmaz, O., Chung, W. O., Watanabe, K., El-Sabeany, A., Park, K. & Lamont, R. J. (2001). Inhibition of epithelial cell apoptosis by Porphyromonas gingivalis. FEMS Microbiol Lett 2000, 145-149.
22. Offenbacher, S. (1996). Periodontal diseases: pathogenesis. Ann Periodontol 1, 821-827.
23. Roberts, F. A., McCaffery, K. A. & Michalek, S. M. (1997). Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res 76, 1833-1839.
24. Sandros, J., Karlsson, C., Lappin, D. F., Madianos, P. N., Kinane, D. F. & Papanou, P. N. (2000). Cytokine responses of oral epithelial cells to Porphyromonas gingivalis infection. J Dent Res 79, 1808-1814.
25. Savit, E. D. & Socransky, S. S. (1984). Distribution of certain subgingival microbial species in selected periodontal conditions. J Periodont Res 19, 111-123.
26. Slots, J. & Listgarten, M. A. (1988). Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J Clin Periodontol 15, 85-93.
27. Socransky, S. & Haffajee, A. D. (1992). The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 63, 322-331.
28. Sugiyama, A., Arakaki, R., Ohnishi, T., Arakaki, N., Daikuhara, Y. & Takada, H. (1996). Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. Infect Immun 64, 1426-1431.
29. Tonetti, M. S., Imboden, M. A., Gerber, L., Lang, N. P., Laissue, J. & Mueller, C. (1994). Localized expression of mRNA for phagocyte-specific chernotactic cytokines in human periodontal infections. Infect Immun 62, 4005-4014.
30. Tonetti, M. S., Cortellini, D. & Lang, N. P. (1998). In situ detection of apoptosis at sites of chronic bacterially induced inflammation in human gingiva. Infect Immun 66, 5190-5195.
31. Uchida, Y., Shiba, H., Komatsuzawa, H., Takemoto, T., Sakata, M., Fujita, T., Kawaguchi, H., Sugai, M. & Kurihara, H. (2001). Expression of IL-1β and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Cytokine 14, 152-161.
32. Wang, C.-Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., Baldwin, A. S. & Baldwin, A. S., Jr (1998). NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683.
33. Wang, D., Baldwin, A. S. & Baldwin, A. S., Jr (1998). Activation of nuclear factor-κB-dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of Re1A/p65 on serine 529. J Biol Chem 273, 29411-29416.
34. Yilmaz, Ö., Jungas, T., Verbeke, P. & Ojcius, D. M. (2004). Activation of phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun 72, 3743-3751.
35. Yoshimura, A., Kaneko, T., Kato, Y., Golenbock, D. T. & Hara, Y. (2002). Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human Toll-like receptor 4. Infect Immun 70, 218-225.
36. Yoshimura, M. Y., Ukai, T., Lien, E., Espevik, T. & Hara, Y. (2003). Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis. Oral Microbiol Immunol 18, 54-58.