Recent progress of Src family kinase inhibitors as anticancer agents

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 10, 2008, Pages 1053-1063

  Cao, Xin ^a   You, Qi Dong ^a   Li, Zhi Yu ^a   Wang, Xiao Jian ^a   Lu, Xiao Yun ^a   Liu, Xiao Rong ^a   Liu, Bao ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer; Drug design; Inhibitor; Kinase domain; Protein tyrosine kinases; SH2; SH3; Src family kinases

Indexed keywords

2 AMINOTHIAZOLE 5 CARBOXAMIDE DERIVATIVE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINOBENZODIOXOLEQUINAZOLINE; ANILINOQUINAZOLINE; ANTINEOPLASTIC AGENT; BENZOTRIAZINE DERIVATIVE; BOSUTINIB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERBSTATIN; ERLOTINIB; FLAVONOID; GEFITINIB; HERBIMYCIN A; INDOLIN 2 ONE DERIVATIVE; INDOLINONE DERIVATIVE; LAVENDUSTIN A; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NATURAL PRODUCT; PEPTIDE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SEMAXANIB; SKS 927; STAUROSPORINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; AUTOPHOSPHORYLATION; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CLINICAL TRIAL; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESOPHAGUS CANCER; HUMAN; IC 50; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; NONHUMAN; PRECANCER; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR VASCULARIZATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; NEOPLASM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; DRUG DESIGN; HUMANS; NEOPLASMS; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56049110266     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708785740634     Document Type: Review

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