Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5546-5550

  Noronha, Glenn ^a   Barrett, Kathy ^a   Cao, Jianguo ^a   Dneprovskaia, Elena ^a   Fine, Richard ^b   Gong, Xianchang ^a   Gritzen, Colleen ^a   Hood, John ^a   Kang, Xinshan ^b   Klebansky, Boris ^b   Li, G ^c   Liao, W ^c   Lohse, Dan ^a   Mak, Chi Ching ^a   McPherson, Andrew ^a   Palanki, Moorthy S S ^a   Pathak, Ved P ^a   Renick, Joel ^a   Soll, Richard ^a   Splittgerber, Ute ^a   Wrasidlo, Wolfgang ^a   Zeng, Binqi ^a   Zhao, Ningning ^a   Zhou, Y ^c   more..

^a TargeGen Inc   (United States)

^b BioPredict Inc   (United States)

^c WUXI APPTEC   (China)

Author keywords

Benzotriazines; Cancer; Kinase inhibitor; Src inhibitor

Indexed keywords

PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TRIAZINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

HUMANS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 33748773109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.035     Document Type: Article

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