11. Gene-environment interactions in environmental lung diseases

Novartis Foundation Symposium

Volumn 293, Issue , 2008, Pages 168-178

  Kleeberger, Steven R ^a   Cho, Hye Youn ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDIZING AGENT; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ENVIRONMENT; ENVIRONMENTAL DISEASE; ENVIRONMENTAL EXPOSURE; GENE; GENETIC PREDISPOSITION; GENETICS; HUMAN; LUNG DISEASE; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BASE SEQUENCE; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL ILLNESS; GENES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG DISEASES; MICE; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; OXIDANTS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 56049090789     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (34)

1. Ames BN, Shigenaga MK 1992 Oxidants are a major contributor to aging. Ann N Y Acad Sci 663:85-96
2. Aoki Y, Sato H, Nishimura N, Takahashi S, Itoh K, Yamamoto M 2001 Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol 173:154-160
3. Arbour NC, Lorenz E, Schutte BC et al 2000 TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187-191
4. Avery ME, Tooley WH, Keller JB et al 1987 Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. Pediatrics 79:26-30
5. Bergamaschi E, De Palma G, Mozzoni P et al 2001 Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects. Am J Respir Crit Care Med 163:1426-1431
6. Chan K, Han XD, Kan YW 2001 An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611-4666
7. Cho HY, Kleeberger SR 2007 Genetic mechanisms of susceptibility to oxidative lung injury in mice. Free Radic Biol Med 42:433-445
8. Cho H, Jedlicka AE, Reddy SP, Zhang LY, Kensler TW, Kleeberger SR 2002a Linkage analysis of susceptibility to hyperoxia: Nrf2 is a candidate gene. Am J Respir Cell Mol Biol 26:42-51
9. Cho HY, Jedlicka AE, Reddy SPM et al 2002b Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175-182
10. Cho HY, Reddy SPM, Yamamoto M, Kleeberger SR 2004 The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 18:1258-1260
11. Cho HY, Reddy SP, DeBiase A, Yamamoto M, Kleeberger SR 2005 Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38:325-343
12. Clark H, Clark LS 2005 The genetics of neonatal respiratory disease. Semin Fetal Neonat Med 10:271-282
13. Clark DA, Pincus LG, Oliphant M, Hubbell C, Oates RP, Davey FR 1982 HLA-A2 and chronic lung disease in neonates. JAMA 248:1868-1869
14. Complex Trait Consortium 2004 The collaborative cross, a community resource for the genetic analysis of complex traits. Nat Genet 36:1133-1137
15. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z 2003 New insights into pathogenesis of asthma. J Clin Invest 111:291-297
16. Floyd RA 1990 Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4:2587-2597
17. Hudak BB, Zhang L-Y, Kleeberger SR 1993 Inter-strain variation in susceptibility to hyperoxic injury of the murine lung. Pharmacogenetics 3:135-143
18. Itoh K, Chiba T, Takahashi S et al 1997 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-232
19. Jenner P 1994 Oxidative damage in neurodegenerative disease. Lancet 344:796-798
20. Jirtle RL, Skinner MK 2007 Environmental epigenomics and disease susceptibility. Nat Rev Genet 8:253-262
21. Kinsella JP, Greenough A, Abman SH 2006 Bronchopulmonary dysplasia. Lancet 367: 1421-1431
22. Kleeberger SR, Peden D 2005 Gene-environment interactions in asthma and other respiratory diseases. Annu Rev Med 56:383-400
23. Kleeberger SR, Schwartz DA 2005 From QTL to gene: a work in progress (editorial). Am J Respir Crit Care Med 171:804-805
24. Kleeberger SR, Levitt RC, Zhang L-Y et al 1997 Linkage analysis of susceptibility to ozoneinduced lung inflammation in inbred mice. Nat Genet 17:475-478
25. Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD 2006 Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med 173:970-976
26. Liao G, Wang J, Guo J, et al 2004 In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science 306:690-695
27. Marzec J, Christie JD, Reddy SP et al 2007 Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J 21:2237-2246
28. Min-Oo G, Fortin A, Pitari G, Tam M, Stevenson MM, Gros P 2007 Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. J Exp Med 204:511-524
29. Nickerson BG, Taussig LM 1980 Family history of asthma in infants with bronchopulmonary dysplasia. Pediatrics 65:1140-1144
30. Pletcher MT, McClurg P, Batalov S et al 2004 Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol 2:2159-2169
31. Poltorak A, He X, Smirnova I et al 1998 Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
32. Ramos-Gomez M, Kwak MK, Dolan PM et al 2001 Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-3415
33. Rangasamy T, Cho CY, Thimmulappa RK et al 2004 Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 114:1248-1259
34. Yang IA, Holz O, Jorres RA et al 2005 Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function. Am J Respir Crit Care Med 171:171-176