Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6147-6150

  Murineddu, Gabriele ^a   Murruzzu, Caterina ^a   Curzu, Maria M ^a   Chelucci, Giorgio ^a   Gotti, Cecilia ^b   Gaimarri, Annalisa ^b   Legnani, Laura ^c   Toma, Lucio ^c   Pinna, Gerard A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

3,6 Diazabicyclo 3.1.1 heptanes; Binding affinity; Modeling; Neuronal nicotinic acetylcholine receptors

Indexed keywords

2 (6 CHLOROPYRIDIN 3 YL) 2,5 DIAZABICYCLO[2.2.1]HEPTANE; 3 (6 BROMOPYRIDIN 3 YL) 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3,6 DIAZABICYCLO[3.1.1]HEPTANE; BUNGAROTOXIN RECEPTOR; EPIBATIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; TEBANICLINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HYDROPHILICITY; INFLAMMATORY DISEASE; NEUROPATHIC PAIN; NONHUMAN; RAT;

BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; HEPTANES; LIGANDS; MOLECULAR STRUCTURE; NICOTINE; NICOTINIC AGONISTS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55849115247     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.002     Document Type: Article

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