Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 3, 2006, Pages 676-691

  Loriga, Giovanni ^a   Manca, Ilaria ^a   Murineddu, Gabriele ^a   Chelucci, Giorgio ^a   Villa, Stefania ^b   Gessi, Stefania ^c   Toma, Lucio ^d   Cignarella, Giorgio ^b   Pinna, Gerard A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Dipartimento di Medicina Clinica e Sperimentale   (Italy)

^d Dipartimento di Chimica   (Italy)

Author keywords

Molecular modelling; Opioid receptors affinities and selectivities; Synthesis of 3,6 diazabicyclo 3.1.1 heptanes

Indexed keywords

3 (3' PHENYLBUT 2' EN 1' YL) 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 (3' PHENYLPENT 2' EN 1' YL) 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 [3' (2 CHLOROPHENYL)PROP 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 [3' (3 CHLOROPHENYL)PROP 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 [3' (3,4 DICHLOROPHENYL)BUT 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 [3' (4 CHLOROPHENYL)BUT 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1] HEPTANE; 3 [3' (4 CHLOROPHENYL)PROP 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 [3' (4 NITROPHENYL)PROP 2' EN 1' YL] 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1] HEPTANE; 3 CINNAMYL 6 PROPIONYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 (3' PHENYLBUT 2' EN 1' YL) 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 (3' PHENYLPENT 2' EN 1' YL) 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 [3' (2 CHLOROPHENYL)PROP 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 [3' (3 CHLOROPHENYL)PROP 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 [3' (3,4 DICHLOROPHENYL)BUT 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 [3' (4 CHLOROPHENYL)BUT 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1] HEPTANE; 3 PROPIONYL 6 [3' (4 CHLOROPHENYL)PROP 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1]HEPTANE; 3 PROPIONYL 6 [3' (4 NITROPHENYL)PROP 2' EN 1' YL] 3,6 DIAZABICYCLO[3.1.1] HEPTANE; 3 PROPIONYL 6 CINNAMYL 3,6 DIAZABICYCLO[3.1.1]HEPTANE; DELTA OPIATE RECEPTOR; HEPTANE DERIVATIVE; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR MODEL; MOUSE; NONHUMAN; RECEPTOR AFFINITY;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; KINETICS; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; THERMODYNAMICS;

ANIMALIA;

EID: 28844505735     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.045     Document Type: Article

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