Pathological and molecular heterogeneity of medulloblastoma

Current Opinion in Oncology

Volumn 20, Issue 6, 2008, Pages 668-675

  Gulino, Alberto ^a,b   Arcella, Antonietta ^b   Giangaspero, Felice ^a,b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Cerebellum; Medulloblastoma; Notch; Sonic hedgehog; Wnt

Indexed keywords

NEUROTROPHIN 3 RECEPTOR;

CEREBELLUM; CHROMOSOME 17P; CHROMOSOME 1Q; CTNNB1 GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENETIC HETEROGENEITY; HEALTH CARE ORGANIZATION; HISTOPATHOLOGY; HUMAN; MEDULLOBLASTOMA; MONOSOMY; ONCOGENE; ONCOGENE MYC; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; REVIEW; STEM CELL;

ADOLESCENT; BRAIN NEOPLASMS; CEREBELLUM; CHILD; CHILD, PRESCHOOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; INFANT; INFANT, NEWBORN; MEDULLOBLASTOMA; QUALITY OF LIFE; RECEPTORS, NOTCH; RISK; TREATMENT OUTCOME; WNT PROTEINS;

EID: 55749108014     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32831369f4     Document Type: Review

References (31)

1. Giangaspero F, Eberhart CG, Bison DW, et al. Medulloblastoma. In: Louis DN, Ohgaki H, Wiestler OD, editors. WHO Classification of Tumours of the Nervous System. Lyon: IARC; 2007.
2. Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Annu Rev Pathol 2008; 3:341-365. A scholarly written review on the molecular basis of morphogenesis of medullo-blastoma.
3. Crawford JR, MacDonald TJ, Packer RJ. Medulloblastoma in childhood: new biological advances. Lancet Neurol 2007; 6:1073-1085.
4. Lament JM, McManamy CS, Pearson AD, et al. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 2004; 10:5482-5493.
5. McManamy CS, Pears J, Weston CL, et al. Nodule formation and desmoplasia in medulloblastomas: defining the nodular/desmoplastic variant and its biological behaviour. Brain Pathol 2007; 17:151-164. This work, focused on nodular/desmoplastic medulloblastoma, shows that this variant has clinical-biological distinctiveness.
6. McManamy CS, Lament JM, Taylor RE, et al. Morphophenotypic variation predicts clinical behavior in childhood nondesmoplastic medulloblastomas. J Neuropathol Exp Neurol 2003; 62:627-632.
7. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002; 94: 552-560.
8. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medullo-blastoma by postoperative chemotherapy alone. N Engl J Med 2005; 352: 978-986.
9. Grill J, Sainte-Rose C, Jouvet A, et al. Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 2005; 6:573-580.
10. Rodriguez FJ, Eberhart C, O'Neill BP, et al. Histopathologic grading of adult medulloblastomas. Cancer 2007; 109:2557-2565.
11. Brandes AA, Franceschi E, Tosoni A, et al. Long-term results of a prospective study on the treatment of medulloblastoma in adults. Cancer 2007; 110: 2035-2041.
12. Lo KC, Rossi MR, Eberhart CG, Cowell JK. Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization. Brain Pathol 2007; 17:282-296.
13. Ferretti E, De Smaele E, Di Marcotullio L, et al. Hedgehog checkpoints in medulloblastoma: the chromosome 17p-deletion paradigm. Trends Mol Med 2005; 11:537-545.
14. Clifford SC, Lusher ME, Lindsey JC, et al. Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular subgroup of medulloblastomas associated with a favorable prognosis. Cell Cycle 2006; 5:2666-2670.
15. Ellison DW, Onilude OE, Lindsey JC, et al. β-Catenin status predicts a favorable outcome in childhood medulloblastoma. J Clin Oncol 2005; 23: 7951-7957.
16. Gajjar A, Chintagumpala M, Ashley D, et al. Risk-adapted craniospmal radiotherapy followed by high-close chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long term results from a prospective, multicentre trial. Lancet Oncol 2006; 7:813-820.
17. Stearns D, Chaudhry A, Abel TW, et al. c-myc overexpression causes anaplasia in medulloblastoma. Cancer Res 2006; 66:673-681.
18. Lo KC, Ma C, Bundy BN, et al. Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. Clin Cancer Res 2007; 13:7022-7028.
19. De Haas T, Hasselt N, Troost D, et al. Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res 2008; 14:4154-4160.
20. Rutkowski S, von Bueren A, von Hoff K, et al. Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. Clin Cancer Res 2007; 13:2651-2657.
21. Fan X, Eberhart CG. Medulloblastoma stem cell. J Clin Oncol 2008; 26: 2821-2827. A good review on the stem cells in cerebellum and in medulloblastoma.
22. Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 2005; 11:17-22.
23. Di Marcotullio L, Ferretti E, Greco A, et al. Numb is a suppressor of Hedgehog signaling and targets Gli 1 for Itch-dependent ubiquitination. Nat Cell Biol 2006; 8:1415-1423.
24. De Smaele E, Fragomeli C, Ferretti E, et al. An integrated approach identifies NhIh1 and Insm 1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma. Neoplasia 2008; 10:89-98.
25. Thompson MC, Fuller C, Hogg TL, et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006; 24:1924-1931.
26. Ferretti E, De Smaele E, Po A, et al. MicroRNA profiling in human medullo-blastoma. Int J Cancer (in press).
27. Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 2005; 4:421-440.
28. Reid S, Schindler D, Hanenberg H, et al. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet 2007; 39:162-164.
29. Yan CT, Kaushal D, Murphy M, et al. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci USA 2006; 103:7378-7383.
30. Eberhart CG. In search of the medulloblast: neural stem cells and embryonal brain tumors. Neurosurg Clin N Am 2007; 18:59-69.
31. Wechsler-Reya R, Read TA. Medulloblastomas from patched mutant mice are propagated by a CD15_ CD133- neural progenitor. Neuro-Oncology 2007; 9:559.