Antitumor activity and some immunological properties of γδ T-cells from patients with gastrointestinal carcinomas

Anticancer Research

Volumn 28, Issue 5 B, 2008, Pages 2921-2931

  Murayama, Minoru ^a   Tanaka, Yoshimasa ^b   Yagi, Junji ^c   Uchiyama, Takehiko ^c   Ogawa, Kenji ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

T cells; Antitumor activity; Cancer immunotherapy; Nonpeptide antigens; Pyrophosphomonoester

Indexed keywords

2 METHYL 3 BUTENYL 1 PYROPHOSPHATE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GASTROINTESTINAL CARCINOMA; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ALKALINE PHOSPHATASE; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, CD3; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOKINES; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; LEUKOCYTES, MONONUCLEAR; NEOPLASMS; ORGANOPHOSPHORUS COMPOUNDS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 55749097971     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Tanaka Y, Brenner MB, Bloom BR and Morita CT: Recognition of nonpeptide antigens by T-cells. J Mol Med 74: 223-231,1996.
2. Morita CT, Lee HK, Leslie DS, Tanaka Y, Bukowski JF and Märker-Hermann E: Recognition of nonpeptide prenyl pyrophosphate antigens by human γδ T-cells. Microbes Infect 1: 175-186, 1999.
3. Hayday AC: γβ Cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol 18: 975-1026, 2000.
4. Kabelitz D: Effector functions and control of human γδ T-cell activation. Microbes Infect 1: 255-261, 1999.
5. Chien YH, Jores R and Crowley MP: Recognition by γδ T-cells. Annu Rev Immunol 14: 511-532, 1996.
6. Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M and Jomma H: Identification of (E)-4-hydroxy- 3-methyl-but-2-enyl pyrophosphate as a major activator for human ãä T-cells in Excherichia coli. FEBS Lett 509: 317-322, 2001.
7. Rohdich F, Hecht S, Gärtner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A and Eisenreich W: Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Proc NaU Acad Sci USA 99: 1158-1163,2002.
8. Cunningham FX Jr, Lafond TP and Gantt E: Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. J Bacteriol 182: 5841-5848, 2000.
9. Kunzmann V, Bauer E and Wilhelm M: γδ T-cell stimulation by pamidronate. N Engl J Med 340: 737-738, 1999.
10. Kunzmann V, Bauer E, Feurle J, Weißinger F, Tony HP and Wihelm M: Stimulation of γδ T-cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96: 384-392, 2000.
11. Gober HJ, Kistowska M, Angman L, Jenö P, Mori L and Libero GD: Human T-cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 197: 163-168, 2003.
12. Morita CT, Jin C, Sarikonda G and Wang H: Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2V-cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol Rev 275: 59-76, 2007.
13. Miyagawa F, Tanaka Y, Yamashita S and Minato N: Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human γδ T-cells by aminobisphosphonate antigen. J Immunol 166: 5508-5514, 2001.
14. Miyagawa F, Tanaka Y, Yamashita S, Mikami B, Danno K, Uehara M and Minato N: Essential contribution of germline-encoded lysine residues in Jγ1.2 segment to the recognition of nonpeptide antigens by human γδ T-cells. J Immunol 167: 6773-6779,2001. 15 Das H, Wang L, Kamath A and Bukowski JF: Vγ2Vδ2 T-cell receptor-mediated recognition of aminobisphosphonates. Blood 98: 1616-1618,2001.
15. Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB and Band H: Vγ2Vδ2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J Immunol 154: 998-1006, 995.
16. Tanaka Y: Human γδ T-cells and tumor immunotherapy. J Clin Exp Hematopathol 46: 11-23, 2006.
17. Wilhelm M, Kunzmann V, Eckstein S, Reimer P, Weissinger F, Ruediger T and Tony HP: γδ T-cells for immune therapy of patients with lymphoid malignancies. Blood 102: 200-206, 2003.
18. Dieli F, Gebbia N, Poccia F, Caccamo N, Montesano C, Filfaro F, Arcara C, Valerio MR, Meraviglia S, Sano CD, Sireci G and Salemo A: Induction of γδ T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 102: 2310-2311,2003.
19. Kobayashi H, Tanaka Y, Yagi J, Toma H and Uchiyama T: γδ T cells provide innate immunity against renal cell carcinoma. Cancer Immunol Immunother 50: 115-24, 2001.
20. Burjanadze M, Condomines M, Reme T, Quittet P, Latry P, Lugagne C, Romagne F, Morel Y, Rossi JF, Klein B and Lu ZY: In vitro expansion of γδ T-cells with anti-myeloma cell activity by Phosphostim and IL-2 in patients with multiple myeloma. Br J Haematol 139: 206-216, 2007.
21. Dieli F, Vermijlen D, Fulfaro F, Caccamo N, Meraviglia S, Cicero G, Roberts A, Buccheri S, D'Asaro M, Gebbia N, Salerno A, Eberl M and Hayday AC: Targeting human γδ T-cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res 67: 7450-7457, 2007.
22. Yamashita S, Tanaka Y, Harazaki M, Mikami B and Minato N: Recognition mechanism of non-peptide antigens by human γδ T-cells. Int Immunol 15: 1301-1307, 2003.
23. Yssel H, De Vries JE, Koken M, Bitterswijk WV and Spits H: Serum-free medium for the generation and the propagation of functional human cytotoxic and helper T-cell clones. J Immunol Methods 72: 219-227, 1984.
24. Takahashi N, Imanishi K, Nishida H and Uchiyama T: Evidence for immunologic immaturity of cord blood T-cells: cord blood T-cells are susceptible to tolerance induction to in vitro stimulation with a superantigen. J Immunol 351: 1614-1619,1995.
25. Migita K, Eguchi K, Tezuka H, Otsubo T, Kawakami A, Nagao H, Ueki Y, Shimomura C, Matsunaga M, Ishikawa N, Ito K and Nagataki S: Cytotoxic activity of interleukin-2 (IL-2) activated killer cells toward thyroid epithelial cells. Clin exp Immunol 77: 196-201, 1989.
26. Morita CT, Lee HK, Wang H, Li H, Mariuzza RA and Tanaka Y: Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human γδ T-cells. J Immunol 167:36-41, 2001.
27. Kato Y, Tanaka Y, Tanaka H, Yamashita S and Minato N: Requirement of species-specific interactions for the activation of human γδ T-cells by pamidronate. J Immunol 170: 3608-3613, 2003.
28. Kato Y, Tanaka Y, Miyagawa F, Yamashita S and Minato N: Targeting of tumor cells for human γδ Ô cells by nonpeptide antigens. J Immunol 767: 5092-5098, 2001.
29. Morita CT, Tanaka Y, Bloom BR and Brenner MB: Direct presentation of non-peptide prenyl pyrophosphate antigens to human γδ T-cells. Res Immunol 147: 347-353,1996.
30. Morita CT, Mariuzza RA, and Brenner MB: Antigen recognition by human γδ T cells: pattern recognition by the adaptive immune system. Springer Semin Immunopathol 22: 191-217, 2000.
31. Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR and Morita CT: Nonpeptide ligands for human γδ T-cells. Proc Natl Acad Sci USA 97: 8175-8179, 1994.
32. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB and Blom BR: Natural and synthetic non-peptide antigens recognized by human γδ T-cells. Nature 375: 155-158, 1995.
33. Allison TJ and Garboczi DN: Structure of γδ T-cell receptors and their recognition of non-peptide antigens. Mol Immunol 38: 1051-1061, 2002.
34. Bukowski JF, Morita CT and Brenner MB: Human γδ T-cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11: 57-65,1999.
35. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE and Brenner MB: Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T-cells. Immunity 3: 495-507, 1995.
36. Thompson K, Dunford JE, Ebetino FH and Rogers MJ: Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun 290: 869-873, 2002.
37. Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH and Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 296: 235-242, 2001.
38. van Beek E, Pieterman E, Cohen L, Löwik C and Papapoulos S: Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates. Biochem Biophys Res Commun 264: 108-111, 1999.
39. van Beek E, Pieterman E, Cohen L, Löwik C and Papapoulos S: Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun 255: 491-494, 1999.
40. Thompson K and Rogers MJ: Stalins prevent bisphosphonate-induced γδ-T-cell proliferation and activation in vitro. J Bone Miner Res 19: 278-288, 2004.
41. Martin MB, Arnold W, Heath HT 3rd Urbina JA and Oldfield E: Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis. Biochem Biophys Res Commun 263: 754-758, 1999.
42. Buckler HM, Mercer SJ, Davison CE, Hollis S, Richardson PC and Anderson DC: Evaluation of adverse experiences related to pamidronate infusion in Paget's disease of bone. Ann Rheum Dis 57: 572, 1998.
43. Adami S, Bhalla AK, Dorizzi R, Montesanti F, Rosini S, Salvagno G and Lo Cascio V: The acute-phase response after bisphosphonate administration. Calcif Tissue Int 41: 326-331, 1987.
44. Poupot M and Fournie JJ: Non-peptide antigens activating human Vγ9/Vδ2 T lymphocytes. Immunol Lett 95: 129-138, 2004.
45. Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G, Bonneville M and Fournié JJ: Stimulation of human γδ T-cells by nonpeptidic mycobacterial ligands. Science 264: 267-270, 1994.