Recognition of nonpeptide antigens by T cells

Journal of Molecular Medicine

Volumn 74, Issue 5, 1996, Pages 223-231

  Tanaka, Y ^a   Brenner, M B ^b   Bloom, B R ^c   Morita, C T ^b  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

DN T cells; lipid antigens; nonpeptide antigens; prenyl pyrophosphate antigens; pyrophosphomonoesters; T cells

Indexed keywords

LIPID; LIPOPOLYSACCHARIDE; PYROPHOSPHATE;

ANTIGEN RECOGNITION; CELLULAR IMMUNITY; HOST RESISTANCE; HUMAN; INFECTION; MOLECULAR BIOLOGY; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0029976502     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00196576     Document Type: Review

References (63)

1. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR (1995) Natural and synthetic nonpeptide antigens recognized by human γδ T cells. Nature 375:155-158
2. + T cells. Nature 372:691-694
3. Bloom BR, Murray CJL (1992) Tuberculosis: commentary on a reemergent killer. Science 257:1055-1064
4. + T cells respond to mycobacterial heat-shock protein. Nature 340:309-312
5. Modlin RL, Pirmez, C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB (1989) Lymphocytes hearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature 339:544-548
6. + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein. J Exp Med 171:667-679
7. O'Brien RL, Happ MP, Dallas A, Palmer L, Kubo R, Born WK (1989) Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from Mycobacterium tuberculosis. Cell 57:667-674
8. De Libero G, Casorati G, Giachino C, Carbonara C, Migone N, Matzinger P, Lanzavecchia A (1991) Selection by two powerful antigens may account for the presence of the major population of human peripheral γ/δ T cells. J Exp Med 173:1311-1322
9. Pfeffer K, Schoel B, Gulle H, Kaufmann SHE, Wagner H (1990) Primary responses of human T cells to mycobacteria: a frequent set of γ/δ T cells are stimulated by protease-resistant ligands. Eur J Immunol 20:1175-1179
10. Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT (1994) Nonpeptide ligands for human γδ T cells. Proc Natl Acad Sci USA 91:8175-8179
11. Constant P, Davodeau F, Peyrat M-A, Poquet Y, Puzo G, Bonneville M, Fournié J-J (1994) Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 264:267-270
12. Schoel B, Sprenger S, Kaufmann SHE (1994) Phosphate is essential for stimulation of Vγ9Vδ2 T lymphocytes by mycobacterial low molecular weight ligand. Eur J Immunol 24:1886-1892
13. Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H (1995) Vγ2Vδ2 TCR-dependent recognition of nonpeptide antigens and Daudi cells analyzed by TCR gene transfer. J Immunol 154:998-1006
14. + human γδ T cells. J Immunol 148:575-583
15. Bürk MR, Mori L, De Libero G (1995) Human Vγ9-Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. Eur J Immunol 25:2052-2058
16. Lang F, Peyrat MA, Constant P, Davodeau F, David-Ameline J, Poquet Y, Vié H, Fournié JJ, Bonneville M (1995) Early activation of human Vγ9Vδ2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands. J Immunol 154:5986-5994
17. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DF, Brenner MB (1995) Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3:495-507
18. Rock EP, Sibbald PR, Davis MM, Chien Y-h (1994) CDR3 lenght in antigen-specific immune receptors. J Exp Med 179:323-328
19. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien Y-h (1994) The nature of major histocompalibility complex recognition by γδ T cells. Cell 76:29-37
20. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA (1994) Unique antigen recognition by a herpesvirus-specific TCR-γδ cell. J Immunol 152:5392-5397
21. Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW, Bluestone JA (1992) A murine CD4, CD8 T cell receptor-γδ T lymphocyte clone specific for herpes simplex virus glycoprotein I. J Immunol 148:983-988
22. Panchamoorthy G, McLean J, Modlin RL, Morita CT, Ishikawa S, Brenner MB, Band H (1991) A predominance of the T cell receptor Vγ2/Vδ2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition. J Immunol 147:3360-3369
23. Ohmen JD, Barnes PE, Uyemura K, Lu SZ, Grisso CL, Modlin RL (1991) The T cell receptors of human γδ T cells reactive to Mycobacterium tuberculosis are encoded by specific V genes hut diverse V-J junctions. J Immunol 147:3353-3359
24. Davodeau F, Peyrat M-A, Hallet M-M, Gaschet J, Houde I, Vivien R, Vie H, Bonneville M (1993) Close correlation between Daudi and mycobacterial antigen recognition by human γδ T cells and expression of V9JPClγ/V2DJCδ-encoded T cell receptors. J Immunol 151:1214-1223
25. Penninger JM, Wen T, Timms E, Potter J, Wallace VA, Matsuyama T, Ferrick D, Sydora B, Kronenberg M, Mak TW (1995) Spontaneous resistance to acute T-cell leukaemias in TCR Vγ1.1JγCγ4 transgenic mice. Nature 375:241-244
26. Porcelli SA (1995) The CD1 family: a third lineage of antigen-presenting molecules. Adv Immunol 59:1-98
27. Porcelli S, Morita CT, Brenner MB (1992) CD1b restricts the response of human CD4 8 T lymphocytes to a microbial antigen. Nature 360:593-597
28. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, Modlin RL (1995) CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227-230
29. Leclercq G, Plum J (1995) Stimulation of TCR Vγ3 cells by Gram-negative bacteria. J Immunol 154:5313-5319
30. Ohga S, Yoshikai Y, Takeda Y, Hiromatsu K, Nomoto K (1990) Sequential appearance of γ/δ- and α/β-bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes. Eur J Immunol 20:533-538
31. Hasegawa T, Tanaka T, Yoshikai Y (1992) The appearance and role of γδ T cells in the peritoneal cavity and liver during primary infection with Listeria monocytogenes in rats. Int Immunol 4:1129-1136
32. Emoto M, Danbara H, Yoshikai Y (1992) Induction of γ/δ T cells in murine salmonellosis by an avirulent by not by a virulent strain of Salmonella choleraesuis. J Exp Med 176:363-372
33. s mice. J Immunol 150:3411-3420
34. Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Mutsumoto K, Bluestone JA, Nomoto K (1992) A protective role of γ/δ T cells in primary infection with Listeria monocytogenes in mice. J Exp Med 175:49-56
35. Fu Y-X, Roark CE, Kelly K, Drevets D, Campbell P, O'Brien R, Born W (1994) Immune protection and control of inflammatory tissue necrosis by γδ T cells. J Immunol 153:3101-3115
36. Mixter PF, Camerini V, Stone BJ, Miller VL, Kronenberg M (1994) Mouse T lymphocytes that express a γδ T-cell antigen receptor contribute to resistance to Salmonella infection in vivo. Infect Immun 62:4618-4621
37. Inoue T, Yoshikai Y, Matsuzaki G, Nomoto K (1991) Early appearing γ/δ-bearing T cells during infection with Calmétte Guérin bacillus. J Immunol 146:2754-2762
38. Janis EM, Kaufmann SHE, Schwartz RH, Pardoll DM (1989) Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244:713-716
39. Skeen MJ, Ziegler HK (1993) Induction of murine peritoneal γ/δ T cells and their role in resistance to bacterial infection. J Exp Med 178:971-984
40. Skeen MJ, Ziegler HK (1993) Intercellular interactions and cytokine responsiveness of peritoneal α/β and γ/δ T cells from Listeria-infected mice: synergistic effects of interleukin 1 and 7 on γ/δ T cells. J Exp Med 178:985-996
41. Vidal S, Tremblay ML, Govoni G, Gauthier S, Sebastiani G, Malo D, Skamene E, Olivier M, Jothy S, Gros P (1995) The Ity/Lsh/BCG locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp I gene. J Exp Med 182:655-666
42. Jones-Carson J, Vazquex-Torres A, van der Heyde HC, Warner T, Wagner RD, Balish E (1995) γ/δ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nat Med 1:552-557
43. + T cells with a transendothelial migratory capacity. J Immunol 153:529-542
44. Diacovo TG, Roth SJ, Morita CT, Rosat J-P, Brenner MB, Springer TA (1995) Interactions of human αβ and γδ T lymphocyte subsets in shear flow with E-selectin and P-selectin. J Exp Med (in press)
45. - T cells with a skewed variable region repertoire after infection with Listeria monocytogenes. Eur J Immunol 25:1985-1991
46. Ladel CH, Hess J, Daugelat S, Mombaerts P, Tonegawa S, Kaufmann SHE (1995) Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis Bacillus Calmette Guérin: studies with T cell receptor-deficient mutant mice. Eur J Immunol 25:838-846
47. Ladel CH, Blum C, Dreher A, Reifenberg K, Kaufmann SHE (1995) Protective role of γ/δ T cells and α/β T cells in tuberculosis. Eur J Immunol 25:2877-2881
48. Mombaerts P, Arnoldi J, Russ F, Tonegawa S, Kaufmann SHE (1993) Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365:53-56
49. Tsuji M, Mombaerts P, Lefrancois L, Nussenzweig RS, Zavala F, Tonegawa S (1994) γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice. Proc Natl Acad Sci USA 91:345-349
50. Hara T, Mizuno Y, Takaki K, Takada H, Akeda H, Aoki T, Nagata M, Ueda K, Matsuzaki G, Yoshikai Y, Nomoto K (1992) Predominant activation and expansion of Vγ9-bearing γδ T cells in vivo as well as in vitro in Salmonella infection. J Clin Invest 90:204-210
51. Sumida T, Maeda T, Takahashi H, Yoshida S, Yonaha F, Sakamoto A, Tomioka H, Koike T, Yoshida S (1992) Predominant expansion of Vγ9/Vδ2 T cells in a tularemia patient. Infect Immunol 60:2554-2558
52. Barnes PF, Grisso CL, Abrams JS, Band H, Rea TH, Modlin RL (1992) γδ T lymphocytes in human tuberculosis. J Infect Dis 165:506-512
53. + antigen receptors are present in increased proportions in a fraction of patients with tuberculosis or with sarcoidosis. Am Rev Respir Dis 148:1685-1690
54. Bertotto A, Gerli R, Spinozzi F, Muscat C, Scalise F, Castellucci G, Sposito M, Candio F, Vaccaro R (1993) Lymphocytes bearing the γδ T cell receptor in acute Brucella melitensis infection. Eur J Immunol 23:1177-1180
55. Ho M, Webster HK, Tongtawe P, Patanapanyasat K, Weidanz WP (1990) Increased γδ T cells in acute Plasmodium falciparum malaria. Immunol Lett 25:139-142
56. Perera MK, Carter R, Goonewardene R, Mendis KN (1994) Transient increase in circulating γ/δ T cells during Plasmodium vivax malarial paroxysms. J Exp Med 179:311-315
57. Scalise F, Gerli R, Castellucci G, Spinozzi F, Fabietti GM, Crupi S, Sensi L, Britta R, Vaccaro R, Bertotto A (1992) Lymphocytes bearing the γδ T-cell receptor in acute toxoplasmosis. Immunology 76:668-670
58. Elloso MM, van der Heyde HC, vande Waa JA, Manning DD, Weidanz WP (1994) Inhibition of Plasmodium falciparum in vitro by human γδ T cells. J Immunol 153:1187-1194
59. Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB (1990) Evidence for extrathymic changes in the T cell receptor γ/δ repertoire. J Exp Med 171:1597-1612
60. Morita CT, Parker CM, Brenner MB, Band H (1994) T cell receptor usage and functional capabilities of human γδ T cells at birth. J Immunol 153:3979-3988
61. Follows GA, Munk ME, Gatrill AJ, Conradt P, Kaufmann SHE (1992) Gamma interferon and interleukin 2, but not interleukin 4, are detectable in γ/δ T-cell cultures after activation with bacteria. Infect Immun 60:1229-1231
62. + αβ T cell and γδ T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production. J Immunol 154:1786-1796
63. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H (1995) Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373:255-257